Drug Name:
ZYLET Rx
Generic Name and Formulations:
Loteprednol etabonate 0.5% + tobramycin 0.3%, oph susp; contains benzalkonium chloride.
Company:
Bausch & Lomb Inc.
Therapeutic Use:
Indications for ZYLET:
Ocular inflammation associated with infection or risk thereof.
Adult:
Instill 1–2 drops into the conjunctival sac of affected eye(s) every 4–6 hours; may increase to every 1–2 hours in first 24–48 hours; reduce dose as symptoms improve; max 20mL for first ℞. Reevaluate if no improvement after 2 days.
Children:
Not recommended.
Contraindications:
Ocular fungal, viral, or mycobacterial infections.
Warnings/Precautions:
Corneal or scleral thinning. Glaucoma. Monitor IOP and for secondary infections and for cataracts in prolonged use (>10 days). Monitor blood levels in combined aminoglycoside therapy. Avoid abrupt cessation. Soft contact lenses (remove during therapy). Pregnancy (Cat.C). Nursing mothers.
Pharmacological Class:
Steroid + aminoglycoside.
Adverse Reactions:
Secondary ocular infections, injection, superficial punctate keratitis, increased IOP, ocular discomfort (eg, burning, stinging, itching, discharge) visual/lacrimation/eyelid disorder, photophobia, corneal deposits, headache. May mask or exacerbate ocular infections. May delay wound healing and increase bleb formation after cataract surgery. In prolonged use: increased IOP, optic nerve damage, cataract formation, corneal perforation.
How Supplied:
Susp—2.5mL, 5mL, 10mL
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