Researchers reviewed evidence relating to the benefits and harms of cranial electrical stimulation for adults with chronic painful conditions, depression, anxiety, and insomnia.
The stimulation of the transient receptor potential vanilloid 1 receptor may explain the benefits of capsaicin and hot water hydrotherapy in patients experiencing cannabinoid hyperemesis syndrome.
For patients presenting to the emergency department in pain, who are subsequently admitted to the hospital, the cost per hour in moderate or severe pain averted is higher for patient-controlled analgesia vs standard care.
Naldemedine, a recently approved agent for opioid-induced constipation, showed good safety and significantly higher responder rates than placebo in a couple of 12-week, international, randomized trials.
