In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).
The 7 opioids included for analysis were oxycodone, hydrocodone, morphine, hydromorphone, oxymorphone, tapentadol, and tramadol.
In patients with concomitant fibromyalgia and PTSD, opioid therapy was shown to improve quality of life and help patients return to a greater sense of "normalcy."
In hospitalized patients, tramadol use was shown to be associated with hypoglycemia.
The extended-release formulation of tramadol was shown to be as effective as buprenorphine and more effective than clonidine for treating symptoms of opioid withdrawal.
Longitudinal opioid prescribing patterns suggest that regular use among patients with rheumatoid arthritis (RA) is slightly declining.
About 20% of U.S. bariatric surgery patients are still using prescription opioids 7 years later.
The FDA is restricting the use of codeine and tramadol medicines in children.
Prescheduled pain management strategies after cesarean delivery are superior to receiving medications on-demand.
Detailed examination of a patient's active medication critically important.
Clinical Pain Advisor Articles
- Abuse-Deterrent Opioid Formulations: Barriers to Broader Use
- Notifications by PDMPs May Not Effectively Reduce Opioid Misuse
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Electroacupuncture May Help Reduce Opioid Use in Chronic Musculoskeletal Pain
- Medical Cannabis Legalization Associated With Reduced Schedule III Opioid Prescriptions
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- Predicting Pain Chronicization After Spine Surgery
- Chronic Low Back Pain Levels Vary Between Sex and Race
- FDA Approval of Medication With a Digital Monitoring System: Major Breakthrough or "Brave New World"?
- Errors in Clinical Notes Generated by Speech Recognition Are Not Uncommon
- Reducing Mortality After Overdose: Is Treatment for Opioid Use Disorder Effective?