Novel 12-LOX Inhibitor Fast Tracked for Heparin-Induced Thrombocytopenia
VLX-1005 is a first-in-class, selective small molecule inhibitor of 12-lipoxygenase, a key target within the arachidonic acid pathway.
Pain Management
Research Needed to Understand Effects of Low-Dose Radiation
Multidisciplinary research is needed to improve understanding of the impact of low doses of radiation on human health.
Adjust Use of Contrast for Pain Procedures During Shortage
Recommendations have been issued by the ASRA and Pain Medicine for interventional pain procedures during the current contrast shortage.
Medical Cannabis Use May Improve Long-Term Depression and Anxiety
Compared with its use for chronic pain, reliable evidence to support the use of cannabis to treat anxiety is lacking and available data are “conflicting.” To bring clarity to the issue, researchers conducted a retrospective database study of Canadian medical cannabis patients.
Cannabinoid Use Increases Sedation Requirements During Endoscopy
Baseline cannabinoid use is associated with higher sedation use during endoscopy with endoscopist-directed conscious sedation.
Rapid Opioid Dose Reduction Increases Overdose Risk in Long-Term, High-Dose Users
Rapid opioid dose reduction or discontinuation exceeding existing pain management guidelines was linked to increased opioid-related harm risk.
High-Dose Gabapentin Linked to Delayed Time to First Opioid Use in Oral Mucositis
For patients receiving concurrent chemoradiotherapy for squamous cell carcinoma of the head and neck, higher doses of gabapentin are well tolerated and associated with delayed time to first opioid use for additional pain control during radiotherapy.
Gabapentin-Involved Overdose Deaths Increased Between 2019 and 2020
Researchers used data from the State Unintentional Drug Overdose Reporting System in order to assess trends in gabapentin-involved overdose deaths.
Combine and Conquer: A Treatment Strategy to Combat Drug-Use Associated Infections
Sandra Springer, MD, and Laura Marks, MD, PhD, highlight the need for a combined treatment approach for patients with drug-use associated infections.
Warning Letters Sent to Online Pharmacies Illegally Selling Schedule II Stimulants
The FDA urges consumers to buy prescription drugs, such as Adderall, from state-licensed US pharmacies or physicians located in the US.
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