Analgesic Ceiling Dose of Ibuprofen for Acute Pain in the ED Determined
Ibuprofen doses of 400, 600, and 800 mg were found to provide comparable analgesia in adult patients seen in the emergency department with moderate to severe acute pain.
Nonsteroidal Anti-Inflammatory Drugs
Reviewing the Safety of Chronic Paracetamol Use for Osteoarthritis Pain
The use of paracetamol for the management of osteoarthritis pain should be further investigated, as the drug may only provide low analgesic benefits, be associated with adverse events, and be toxic at higher doses.
NSAID, Metoclopramide Use Associated With Insulin Resistance in Women With Migraine
The use of metoclopramide and non-steroidal anti-inflammatory drugs during migraine attacks may be associated with insulin resistance in women with migraine.
Risk Score May Help Predict 1-Year Major Toxicity Risk in NSAID Users
A risk score may help predict the 1-year risk for major toxicity in patients taking nonsteroidal anti-inflammatory drugs.
Oral NSAIDs for Knee OA: Duration of Efficacy, Time to Adverse Event Onset Examined
A systematic review and meta-analysis published in Arthritis Care & Research aimed to assess the duration of efficacy, as well as the onset of adverse events, associated with oral nonsteroidal anti-inflammatory drugs (NSAIDS) used in the treatment of knee osteoarthritis (OA). To investigate these outcomes, researchers conducted a literature search which identified 72 randomized controlled…
Tramadol as First-Line Therapy for OA May Be Associated With Greater Mortality
Treating osteoarthritis in older patients with tramadol vs nonsteroidal anti-inflammatory drugs may be associated with an increased mortality rate during the year following treatment initiation.
NSAID Allergy May Increase Risk for Opioid Use Disorder
Patients with low back pain or osteoarthritis who reported adverse drug reactions to NSAIDs have significantly higher odds of receiving prescriptions for opioids and developing opioid use disorder.
Authorized Generic of Flector Patch Now Available From Teva
An authorized generic of Flector Patch (diclofenac epolamine topical patch) has been made available by Teva Pharmaceuticals for the topical treatment of acute pain due to minor strains, sprains, and contusions.
Risks Associated With Co-Administration of Aspirin and Other NSAIDs
In patients with rheumatoid arthritis or osteoarthritis who are at higher risk for cardiovascular events, celecoxib may be safer compared with naproxen or ibuprofen when these drugs are taken alone or in combination with aspirin.
Evaluating Analgesic Benefits of NSAID Combinations for Acute Postoperative Dental Pain
Acetaminophen in combination with ibuprofen or oxycodone, as well as diclofenac, and flurbiprofen may offer more effective analgesia for acute postoperative dental pain in adults.
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