Relative Efficacy of Pharmacotherapy for Diabetic Peripheral Neuropathy
This systematic review and Bayesian meta-analysis evaluated the relative efficacy of 18 oral pharmacotherapeutic interventions for diabetic peripheral neuropathy.
Neuropathic Pain
Eplontersen Meets Endpoints in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Eplontersen is an investigational ligand-conjugated antisense medicine designed to reduce the production of TTR protein to treat both hereditary and nonhereditary forms of ATTR.
Vutrisiran Approved for Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis
Amvuttra is a subcutaneously-administered RNAi therapeutic designed to block the production of wild-type and mutant transthyretin protein.
Topical Amitriptyline Granted Fast Track Status for Chemotherapy-Induced Neuropathic Pain
ATX01 is a topical formulation of amitriptyline designed to directly inhibit pain signaling in the nerve fibers on the epidermis and dermis.
Modest Beneficial Effects With Topical Clonidine for Painful Diabetic Neuropathy
This Cochrane review aimed to assess the analgesic efficacy of topical clonidine for adults with chronic neuropathic pain.
Real-World Data Confirm Utility of Lidocaine Medicated Plaster for Localized Peripheral Neuropathic Pain
Lidocaine medicated plaster effectively improved localized peripheral neuropathic pain.
Subcutaneous Botulinum Toxin Injections Reduced Chronic Peripheral Neuropathic Pain
A systematic review evaluated the efficacy of botulinum A toxin for chronic peripheral neuropathic pain.
Predictors of Complex Regional Pain Syndrome After Knee Arthroplasty
CRPS was associated with temperature asymmetry, skin color asymmetry, asymmetric edema, motor changes, allodynia, and hyperalgesia.
Gabapentin-Involved Overdose Deaths Increased Between 2019 and 2020
Researchers used data from the State Unintentional Drug Overdose Reporting System in order to assess trends in gabapentin-involved overdose deaths.
Are Biologic Therapies Effective for Neuropathic Pain?
This systematic review did not find any high quality evidence supporting the use of injectable biologics for neuropathic pain.
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