Overcoming the Barriers to Including Pregnant Women in Clinical Trials
Pregnant women are considered a “vulnerable” population in the eyes of clinical researchers.
Clinical Trials
Topical Migraine Trigger Point Treatment as Effective as Injection
In a retrospective analysis, investigators assessed the effects of topical trigger point treatments on headache symptoms in patients with migraine.
Standardized Funder Policies Will Improve Transparency, Publication Bias in Clinical Trials
Research findings suggest the need for greater adherence to a standardized set of policies aimed at improving transparency among clinical trial funders.
Risks and Benefits of FDA “Pre-Cert” Program for Medical Software Devices Examined
The FDA Digital Health Software Precertification Program represents a feasible solution to regulate software classified as a medical device.
Addressing Barriers to Translational Pain Research
Many translational barriers exist between preclinical research and clinical practice.
ACTTION Consensus Provides Best Practices for the Design of Pediatric Clinical Trials Focused on Acute Pain
Key factors susceptible to improve the design of clinical trials on analgesics for acute pain in pediatric populations were reviewed and recommendations published.
Clinical Trials May Overestimate Benefits of Cannabis Therapy
The benefits associated with medical cannabis therapy may be overestimated due to inadequate blinding in clinical trials.
Data Transparency and Publication Bias: Impact on Clinical Trials
The need for data transparency carries an ethical and moral obligation and requires nonselective and unbiased publication of clinical results.
Reducing the P-Value for Statistical Significance to Improve the Quality of Research?
In a controversial and divisive article, a group of researchers proposes to improve “statistical standards of evidence” by lowering the P value from P <.05 to P <.005 in the fields of biomedical and social sciences.
Cancer-specific Reference Values Specified for PROMIS Domains
Reference values for PROMIS domains have been established by a population-based study.
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