Some Patients With Chronic Pain May Find Relief Using Antidepressants
More studies about antidepressants as chronic pain therapy are needed because current drug treatments are ineffective and pose a high risk for serious harm.
Antidepressants
Off-Label Use of Antidepressants for Chronic Pain
In recent years, the off-label prescription of antidepressants for the treatment of chronic pain has increased, along with evidence of their effectiveness and mechanistic underpinnings when used for this purpose. Depression is a common comorbidity among patients with chronic pain, and the use of these agents may alleviate symptoms of both disorders. Typically, however, significantly…
Risks for Cardiovascular, Cerebrovascular Events in Individuals Taking Migraine Prophylactics
Individuals taking certain prophylactic migraine treatments were found to be at increased risk for cardiovascular and cerebrovascular events.
Antidepressant Medications and Headache: Is There a Link?
Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).
Exploring the Connections Between Neuropathic Pain and Comorbid Mood Disorders
Substantial evidence suggests a close connection between neuropathic pain and mood disorders.
Comparing the Efficacy of Postherpetic Neuralgia Treatments for Pain Relief
Analgesics may be more effective in alleviating pain associated with postherpetic neuralgia compared with topical therapies, antivirals, antidepressants, and antiepileptics.
Recurrent Chest Pain Linked to Depression, Anxiety
Depression, anxiety, and perceived stress scores were all positively correlated with increasing chest pain frequency, and the relationship was significant for depression.
Antidepressants for Chronic Pediatric Pain?
No conclusive evidence was found supporting the efficacy of antidepressants in the pediatric population.
Antidepressant Use During Pregnancy, Offspring Intellectual Disability Not Linked
There is no association between intellectual disability and maternal use of antidepressants during pregnancy.
Response to Pregabalin for Fibromyalgia-Related Pain in Patients Taking Antidepressants
Researchers identified characteristics associated with pain improvement in patients with fibromyalgia who take antidepressant medications.
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