In recent years, the off-label prescription of antidepressants for the treatment of chronic pain has increased, along with evidence of their effectiveness and mechanistic underpinnings when used for this purpose. Depression is a common comorbidity among patients with chronic pain, and the use of these agents may alleviate symptoms of both disorders. Typically, however, significantly…
Individuals taking certain prophylactic migraine treatments were found to be at increased risk for cardiovascular and cerebrovascular events.
Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).
Substantial evidence suggests a close connection between neuropathic pain and mood disorders.
Analgesics may be more effective in alleviating pain associated with postherpetic neuralgia compared with topical therapies, antivirals, antidepressants, and antiepileptics.
Depression, anxiety, and perceived stress scores were all positively correlated with increasing chest pain frequency, and the relationship was significant for depression.
No conclusive evidence was found supporting the efficacy of antidepressants in the pediatric population.
There is no association between intellectual disability and maternal use of antidepressants during pregnancy.
Researchers identified characteristics associated with pain improvement in patients with fibromyalgia who take antidepressant medications.
Obesity and sex are differential predictors of acute remission for commonly used antidepressant medications.
