Generic Name and Formulations:
Sulindac 150mg, 200mg; scored tabs.
Various generic manufacturers
Indications for Sulindac:
Rheumatoid arthritis. Osteoarthritis. Ankylosing spondylitis. Acute painful shoulder. Acute gouty arthritis.
Take with food. 150mg twice daily. Acute painful shoulder or gouty arthritis: 200mg twice daily, usually for 7–14 days. All: max 400mg/day.
Aspirin allergy. Coronary artery bypass graft surgery.
Advanced renal disease: not recommended. Active or history of GI bleeding, peptic ulcer, or kidney stones. Heart failure. Impaired renal or hepatic function. Edema. Hypertension. Bleeding disorders. Sepsis. Diabetes. Preexisting asthma. Maintain adequate hydration. Monitor blood, hepatic, renal, and ocular function in chronic use. Discontinue if unexplained fever, pancreatitis, or liver dysfunction occurs. Systemic lupus erythematosus and mixed connective tissue disease. Elderly. Debilitated. Pregnancy (Cat.C); avoid in late pregnancy. Nursing mothers: not recommended.
NSAID (indene deriv.).
Increased risk of GI toxicity with aspirin, other NSAIDs, alcohol, smoking. Probenecid increases serum levels. Diflunisal reduces serum levels. Antagonized by, and peripheral neuropathy with, DMSO. Monitor anticoagulants, antihyperglycemics. Caution with methotrexate, cyclosporine, nephrotoxic drugs (increased toxicity). Increased serum lithium levels (monitor). May antagonize diuretics, ACE inhibitors, angiotensin II antagonists (monitor).
GI ulcer/bleeding/pain, dyspepsia, nausea, diarrhea, constipation, rash (discontinue if occurs), dizziness, headache, tinnitus, edema, nephritis, nephrotic syndrome, pancreatitis, jaundice, hepatitis. See literature re: risk of cardiovascular events.
Formerly known under the brand name Clinoril.
Clinical Pain Advisor Articles
- History of Migraine May Be Associated With Higher Risk for Cochlear Disorders
- Radiofrequency Denervation Efficacious in Treating Thoracic Zygapophyseal Joint Pain
- Symptom Severity, Sensory Sensitivity May Indicate Pain Centralization in Chronic Overlapping Pain Conditions
- Stat Consult: Chronic Low Back Pain
- Opioid Misuse May Help Predict Alcohol Dependence Treatment Outcomes
- Consensus Guidelines for the Use of Intravenous Ketamine for Chronic Pain
- Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain
- Labor Epidural Analgesia Linked to Reduced Likelihood of Successful Breastfeeding
- Novel Oral Treatment Safe, Effective for Migraine Headache Relief
- DFN-02 Nasal Spray Safe, Effective for Acute Treatment of Episodic Migraine
- Chinese Traditional Medicine Showed Effectiveness on Pain, Quality of Life in Advanced Cancer
- International Group Develops Best Practices for Drug Packaging
- New Rules May Constrain Docs' Ability to Treat Chronic Pain
- OnabotulinumtoxinA May Be Effective for Chronic Migraine With Medication Overuse
- FDA Outlines Plan for Increasing Nonprescription Drug Availability