Generic Name and Formulations:
Trimethoprim (as HCl) 50mg/5mL; bubble-gum flavored soln; alcohol- and dye-free.
Aytu BioScience, Inc.
Indications for PRIMSOL:
Susceptible acute otitis media (AOM) due to S. pneumoniae or H. influenzae in children. Susceptible initial episodes of uncomplicated UTIs in adults.
UTIs: 100mg twice daily, or 200mg once daily; both for 10 days. Renal dysfunction: CrCl 15–30mL/min: reduce dose by ½; CrCl <15mL/min: not recommended.
<6months: not recommended. ≥6months: AOM: 10mg/kg daily in 2 divided doses every 12 hours for 10 days. Renal dysfunction: CrCl 15–30mL/min: reduce dose by ½; CrCl <15mL/min: not recommended.
Megaloblastic anemia due to folate deficiency.
Avoid large doses or prolonged administration (increased risk of blood disorders). Monitor CBC, discontinue if signs of blood disorders occur. Possible folate deficiency (may give folate concomitantly). Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers.
Folic acid inhibitor.
May potentiate phenytoin. May interfere with some creatinine tests (alkaline picrate reduction).
Rash, GI upset, hematological or renal effects.
Clinical Pain Advisor Articles
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Reducing Mortality After Overdose: Is Treatment for Opioid Use Disorder Effective?
- A Physician's Guide to Incorporating Patient Spirituality in Practice
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- The Challenge of Compassion in Modern Healthcare Settings
- Republican Opposition to Obamacare: What's Done, What's to Come
- Lowering Default Pill Counts in EMRs May Effectively Reduce Postoperative Opioid Prescription Numbers
- Steps Taken to Increase Use of Electronic Tools in Medicine
- Daily and Retrospective Pain Measurements Comparable in Hip Osteoarthritis