Generic Name and Formulations:
Sodium picosulfate 10mg, magnesium oxide 3.5g, anhydrous citric acid 12g; per packet; powder for oral solution after reconstitution; orange- or cranberry-flavor.
Ferring Pharmaceuticals, Inc.
Indications for PREPOPIK:
Bowel cleansing before colonoscopy.
Split-Dose regimen (preferred): Take 1st dose evening before colonoscopy followed by five 8oz drinks of clear liquids before bed. Consume clear liquids within 5hrs. Take 2nd dose, the next day approximately 5hrs before colonoscopy followed by at least three 8oz drinks of clear liquids. Consume clear liquids within 5hrs up until 2hrs before procedure. Day-Before regimen (alternative): Take 1st dose in the afternoon or early evening before colonoscopy followed by five 8oz drinks of clear liquids before the next dose. Take 2nd dose approximately 6hrs later in the late evening, the night before colonoscopy followed by three 8oz drinks of clear liquids before bed. Consume clear liquids within 5hrs.
Severe renal impairment (CrCl <30mL/min). GI obstruction. Ileus. Bowel perforation. Toxic colitis or megacolon. Gastric retention.
Correct fluid/electrolyte abnormalities before use. CHF. History or risk of seizures. Alcohol or benzodiazepine withdrawal. Renal impairment; consider baseline and post-colonoscopy lab tests. Increased risk of arrhythmias; consider pre-dose and post-colonoscopy ECGs. Mucosal ulcerations may occur; consider when interpreting findings in inflammatory bowel disease. Rule out GI obstruction/perforation before administering. Severe active ulcerative colitis. Impaired gag reflex. Risk of regurgitation or aspiration. Maintain adequate hydration. Pregnancy (Cat.B). Nursing mothers.
Stimulant + osmotic laxative.
Caution with drugs that increase risk of fluid/electrolyte abnormalities (eg, diuretics, corticosteroids, cardiac glycosides, NSAIDs, tricyclics, SSRIs, antipsychotics, carbamazepine) or that affect renal function (eg, ACEIs, ARBs). Oral drugs given within 1hr of start of administration may not be absorbed. Separate dosing of tetracyclines, fluoroquinolones, iron, digoxin, chlorpromazine, or penicillamine by at least 2hrs before or >6hrs after Prepopik. Antibiotics may reduce efficacy. Caution with drugs that lower seizure threshold. Increased risk of colonic mucosal ulcerations or ischemic colitis with stimulant laxatives.
Nausea, headache, vomiting.
Carton—1 (2 packets w. dosing cup)
Clinical Pain Advisor Articles
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Reducing Mortality After Overdose: Is Treatment for Opioid Use Disorder Effective?
- A Physician's Guide to Incorporating Patient Spirituality in Practice
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- The Challenge of Compassion in Modern Healthcare Settings
- Republican Opposition to Obamacare: What's Done, What's to Come
- Lowering Default Pill Counts in EMRs May Effectively Reduce Postoperative Opioid Prescription Numbers
- Steps Taken to Increase Use of Electronic Tools in Medicine
- Daily and Retrospective Pain Measurements Comparable in Hip Osteoarthritis