Post-Surgical Pain

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Optimal Strategies for Opioid Weaning After Ambulatory Surgery

Optimal Strategies for Opioid Weaning After Ambulatory Surgery

Although there is a scarcity of evidence pertaining to the management of postoperative pain medication in the ambulatory setting, some findings suggest an approach similar to that used for the treatment of acute pain.

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Quantity of Opioids Prescribed Linked to Higher Patient-Reported Consumption

Quantity of Opioids Prescribed Linked to Higher Patient-Reported Consumption

The quantity of postsurgical opioids prescribed may be associated with higher patient-reported opioid consumption.

Dextenza Approved for Ocular Pain Following Ophthalmic Surgery

Dextenza Approved for Ocular Pain Following Ophthalmic Surgery

The approval was based on data from 2 vehicle-controlled Phase 3 trials.

Patients Undergoing Thyroid Surgery May Require Few Opioids

Patients Undergoing Thyroid Surgery May Require Few Opioids

Patients undergoing thyroid and parathyroid surgery may require few to no opioid medications postoperatively.

FDA Grants Non-Opioid Analgesic VVZ-149 Fast Track Status

FDA Grants Non-Opioid Analgesic VVZ-149 Fast Track Status

The Company states that in vivo tests have shown that the compound's pain suppressing efficacy is comparable to morphine.

NDA for Non-Opioid Combo Treatment for Postoperative Pain Submitted to FDA

NDA for Non-Opioid Combo Treatment for Postoperative Pain Submitted to FDA

The treatment is designed to deliver pain relief directly to the site of tissue injury, thereby potentially reducing the need for systemically administered pain medications.

Clinician Characteristics Associated With Outpatient Postoperative Opioid Prescribing

Clinician Characteristics Associated With Outpatient Postoperative Opioid Prescribing

Advanced practice providers were found to prescribe more opioids and in larger quantities compared with other physicians.

Reviewing the Links Between Opioids and Complications After Spine Surgery

Reviewing the Links Between Opioids and Complications After Spine Surgery

For patients undergoing cervical or lumbar spinal fusions, postoperative pain management with opioids is associated with higher postoperative pain scores and worse quality of life.

Patients Assume Postoperative Opioids Are Best for Pain Relief

Patients Assume Postoperative Opioids Are Best for Pain Relief

Patients undergoing surgery assume opioids will be most effective for postoperative pain relief, even if they don't expect to be prescribed opioids.

Hydrocodone Schedule Change Affected Post-Operative Opioid Prescriptions

Hydrocodone Schedule Change Affected Post-Operative Opioid Prescriptions

Hydrocodone's change from schedule III to schedule II in 2014 was associated with an increase in the amount of opioids filled in the initial prescription after surgery.

Celecoxib Offers Pain Relief Comparable to Ketorolac After Robotic Hysterectomy

Celecoxib Offers Pain Relief Comparable to Ketorolac After Robotic Hysterectomy

Patients undergoing robotic hysterectomy were found to report comparable pain scores when receiving celecoxib perioperatively or ketorolac postoperatively.

First-in-Class Non-Opioid for Post-Surgical Pain Gets Breakthrough Tx Designation

First-in-Class Non-Opioid for Post-Surgical Pain Gets Breakthrough Tx Designation

CA-008 is given as a single local injection and works by selectively desensitizing pain-conducting nerve fibers without causing numbness or weakness

Adjunctive Methadone Use May Reduce Post-Spinal Fusion Opioid Requirements in Pediatric Patients

Adjunctive Methadone Use May Reduce Post-Spinal Fusion Opioid Requirements in Pediatric Patients

Methadone vs desflurane as an adjunct to remifentanil may contribute to reducing perioperative opioid requirements in adolescents undergoing spinal surgery.

Role of the Perioperative Surgical Home in the Context of the Opioid Epidemic

Role of the Perioperative Surgical Home in the Context of the Opioid Epidemic

The integration of a Transitional Pain Service into a perioperative surgical home model could optimize perioperative pain control and opioid use, while reducing postdischarge hospital readmissions as well as the costs and disability linked to chronic postsurgical pain.

Predicting Pain Chronicization After Spine Surgery

Predicting Pain Chronicization After Spine Surgery

The Pain Sensitivity Questionnaire and Pain Catastrophizing Scale were found to be predictive of a chronically painful state in patients undergoing spine surgery in a comparable manner.

Wide Variations in Opioid Prescribing Practices for Surgical Procedures

Wide Variations in Opioid Prescribing Practices for Surgical Procedures

Variation exists in opioid prescribing practices among clinicians in single-hospital systems, which prompts concern about the potential for opioid overprescribing.

Women Frequently Prescribed High Doses of Opioids After Vaginal Delivery

Women Frequently Prescribed High Doses of Opioids After Vaginal Delivery

Women who undergo vaginal delivery in the United States may frequently be prescribed opioid medications for pain within 1 week of hospital discharge, often dispensed at high doses and in significant quantities.

Preoperative Opioid Use Highly Prevalent, Associated With Age, Tobacco Use

Preoperative Opioid Use Highly Prevalent, Associated With Age, Tobacco Use

Preoperative opioid use was reported by approximately 23% of patients undergoing surgery, with age, tobacco use, depression, poor life satisfaction, and medical comorbidities identified as independent factors associated with pre-interventional opioid use.

Postpartum Pain Management Recommendations From the American College of Obstetricians and Gynecologists

Postpartum Pain Management Recommendations From the American College of Obstetricians and Gynecologists

A committee from the American College of Obstetricians and Gynecologists formulated several recommendations for safely managing pain and fatigue in women during the early postpartum period.

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.

Labor Epidural Analgesia Linked to Reduced Likelihood of Successful Breastfeeding

Labor Epidural Analgesia Linked to Reduced Likelihood of Successful Breastfeeding

Labor epidural analgesia may be associated with reduced likelihood of breastfeeding at 6 weeks.

Post-Op Pain Treatment Gets Breakthrough Therapy Designation

Post-Op Pain Treatment Gets Breakthrough Therapy Designation

The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.

Opioid-Related Adverse Events Common After Invasive Procedures

Opioid-Related Adverse Events Common After Invasive Procedures

For patients undergoing invasive procedures, opioid-related adverse drug events are common and are associated with worse clinical and cost outcomes.

Opioid-Free Analgesia Use for Postsurgical Pain Limited

Opioid-Free Analgesia Use for Postsurgical Pain Limited

The use of opioid-free analgesia to manage postsurgical pain is still limited, particularly in some patient groups that may be at a higher risk for opioid-related adverse drug events.

Clonidine May Not Improve Post-Cesarean Delivery Analgesia

Clonidine May Not Improve Post-Cesarean Delivery Analgesia

Administration of clonidine — intrathecally or intravenously — may not supplement spinal anesthesia-associated analgesia after cesarean delivery.

Factors ID'd for Persistent Opioid Use After Pediatric Surgery

Factors ID'd for Persistent Opioid Use After Pediatric Surgery

With the distinct qualities that come from post-surgical procedures in the realm of pediatrics, conclusions are still being considered.

Benefit of Liposomal Bupivacaine for Pain in TKA Questioned

Benefit of Liposomal Bupivacaine for Pain in TKA Questioned

Liposomal bupivacaine use in patients undergoing total knee arthroplasty is not associated with clinically meaningful reductions in inpatient opioid use, resource utilization, or opioid-related complications.

Perioperative Lidocaine May Reduce Risk for Chronic Postsurgical Pain

Perioperative Lidocaine May Reduce Risk for Chronic Postsurgical Pain

Perioperative lidocaine infusions may reduce the likelihood of developing chronic postsurgical pain.

Anesthetic-Loaded Bone Cements May Accelerate Post-Reconstruction Recovery

Anesthetic-Loaded Bone Cements May Accelerate Post-Reconstruction Recovery

Calcium phosphate cement loaded with bupivacaine vs ropivacaine may accelerate functional recovery after bone reconstruction surgery and maintain bone-filling properties.

Regional Anesthesia Tied to Lower Opioid Use in TKA, THA

Regional Anesthesia Tied to Lower Opioid Use in TKA, THA

Regional anesthesia is associated with a lower opioid consumption in both knee and hip replacement surgeries, compared to general anesthesia.

Efficacy of IV Meloxicam for Bunionectomy-Associated Pain

Efficacy of IV Meloxicam for Bunionectomy-Associated Pain

A once-daily intravenous injection of meloxicam may safely and effectively relieve moderate to severe bunionectomy-associated pain.