Although there is a scarcity of evidence pertaining to the management of postoperative pain medication in the ambulatory setting, some findings suggest an approach similar to that used for the treatment of acute pain.
Hydrocodone's change from schedule III to schedule II in 2014 was associated with an increase in the amount of opioids filled in the initial prescription after surgery.
Patients undergoing robotic hysterectomy were found to report comparable pain scores when receiving celecoxib perioperatively or ketorolac postoperatively.
CA-008 is given as a single local injection and works by selectively desensitizing pain-conducting nerve fibers without causing numbness or weakness
Methadone vs desflurane as an adjunct to remifentanil may contribute to reducing perioperative opioid requirements in adolescents undergoing spinal surgery.
The integration of a Transitional Pain Service into a perioperative surgical home model could optimize perioperative pain control and opioid use, while reducing postdischarge hospital readmissions as well as the costs and disability linked to chronic postsurgical pain.
The Pain Sensitivity Questionnaire and Pain Catastrophizing Scale were found to be predictive of a chronically painful state in patients undergoing spine surgery in a comparable manner.
Variation exists in opioid prescribing practices among clinicians in single-hospital systems, which prompts concern about the potential for opioid overprescribing.
Women who undergo vaginal delivery in the United States may frequently be prescribed opioid medications for pain within 1 week of hospital discharge, often dispensed at high doses and in significant quantities.
Preoperative opioid use was reported by approximately 23% of patients undergoing surgery, with age, tobacco use, depression, poor life satisfaction, and medical comorbidities identified as independent factors associated with pre-interventional opioid use.
Postpartum Pain Management Recommendations From the American College of Obstetricians and Gynecologists
A committee from the American College of Obstetricians and Gynecologists formulated several recommendations for safely managing pain and fatigue in women during the early postpartum period.
Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR
Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.
Labor epidural analgesia may be associated with reduced likelihood of breastfeeding at 6 weeks.
The Company indicated that they will work towards an New Drug Application submission for the treatment in the second half of 2018.
For patients undergoing invasive procedures, opioid-related adverse drug events are common and are associated with worse clinical and cost outcomes.
The use of opioid-free analgesia to manage postsurgical pain is still limited, particularly in some patient groups that may be at a higher risk for opioid-related adverse drug events.
Administration of clonidine — intrathecally or intravenously — may not supplement spinal anesthesia-associated analgesia after cesarean delivery.
With the distinct qualities that come from post-surgical procedures in the realm of pediatrics, conclusions are still being considered.
Liposomal bupivacaine use in patients undergoing total knee arthroplasty is not associated with clinically meaningful reductions in inpatient opioid use, resource utilization, or opioid-related complications.
Perioperative lidocaine infusions may reduce the likelihood of developing chronic postsurgical pain.
Calcium phosphate cement loaded with bupivacaine vs ropivacaine may accelerate functional recovery after bone reconstruction surgery and maintain bone-filling properties.
Regional anesthesia is associated with a lower opioid consumption in both knee and hip replacement surgeries, compared to general anesthesia.
A once-daily intravenous injection of meloxicam may safely and effectively relieve moderate to severe bunionectomy-associated pain.
Adverse events associated with opioids administered for the management of postsurgical and postendoscopy pain may be associated with worse cost and patient outcomes.
In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).
The management of postsurgical pain with patient-controlled analgesia pumps may be safe, as indicated by a low rate of device-related error.
The researchers found that the median prescription size was 350 mg oral morphine equivalents and median patient use was 225 mg oral morphine equivalents following open hiatal hernia repair.
Acetaminophen in combination with ibuprofen or oxycodone, as well as diclofenac, and flurbiprofen may offer more effective analgesia for acute postoperative dental pain in adults.
Researchers conducted a prospective survey of patients to investigate postoperative opioid use.
An elastic net algorithm was used to create a predictive model of postoperative pain in the first 24 hours after surgery using a randomly selected training cohort.
Opioids and sedatives may represent independent and additive predictors of cardiopulmonary and respiratory arrest in both medical and surgical patients.
Clinical Pain Advisor Articles
- Association Between Headache Attributed to Temporomandibular Disorders and Comorbid Bodily Pain
- Involvement and Diagnosis of Myofascial Trigger Points in Migraine, Tension-Type Headache
- Mobile Health-Supported Trials to Assess Chronic Musculoskeletal Pain Treatments
- Altered Brain Connectivity Patterns Associated With THC-Induced Analgesia
- Potentially Inappropriate Opioid Prescribing Tied to Overdose
- Perioperative Pain Management in Patients With Opioid Use Disorder
- Antidepressant Effects of Ketamine Appear to Require Opioid System Activation
- Reviewing the Efficacy of Intrathecal Morphine, Ziconotide for Cancer- and Noncancer Chronic Pain
- Popular Heroin Inhalation Method Tied to Leukoencephalopathy
- Managing Comorbid Opioid and Alcohol Use Disorder
- Supervised Injection Sites: Facts, Information, Pros, and Cons
- Adverse Childhood Experienced Linked to Urologic Chronic Pelvic Pain Syndrome Symptoms
- FDA Committee Votes on First-of-Its-Kind Pain Drug Oliceridine
- Chronic Pain May Be a Contributing Factor to Suicide
- The Open Access Debate: Should Patients Freely Access Research?