Chronic Postoperative Pain Risk Linked to Gene Polymorphisms

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Brain-derived neurotrophic factor was found to be most associated with increased chronic postsurgical pain.
Brain-derived neurotrophic factor was found to be most associated with increased chronic postsurgical pain.

HealthDay News — Genetics may be a factor in the experience of chronic pain post surgery, according to a study published online in Anesthesiology.

Yuanyuan Tian, PhD, from the Chinese University of Hong Kong, and colleagues genotyped 638 polymorphisms within 54 pain-related genes in 1152 surgical patients who were enrolled in the Persistent Pain after Surgery Study. Polymorphisms were validated in a matched cohort of 103 patients with chronic postsurgical pain and 103 pain-free patients.

The researchers found that 21.4% of patients reported chronic postsurgical pain at 12 months after surgery. Forty-two polymorphisms were correlated with chronic postsurgical pain: 19 and 23 decreased and increased the risk for pain, respectively. Brain-derived neurotrophic factor (BDNF) was found to be most associated with increased chronic postsurgical pain.

Other factors associated with an increased risk for pain were: age less than 65 years, male sex, and prior history of pain syndrome. The population attributable risk was higher for genetic polymorphisms (7.36% to 11.7%) than clinical risk factors (2.9% to 5.93%).

"Our study not only shows there are common genetic variations among people that may help to identify whether they are at high risk for developing chronic pain after surgery, but it also helps explain why only a fraction of patients ever even experience persistent pain," lead researcher Matthew T.V. Chan, MD, of the Chinese University of Hong Kong, said in a statement. "Until now, the genetic variations associated with chronic postsurgical pain have not been well identified."

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Reference

Tian Y, Liu X, Jia M, et al. Targeted genotyping identifies susceptibility locus in brain-derived neurotrophic factor gene for chronic postsurgical pain [published online December 14, 2017]. Anesthesiology. doi: 10.1097/ALN.0000000000001977

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