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PLIAGLIS
Topical pain relief
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Drug Name:

PLIAGLIS Rx

Generic Name and Formulations:
Lidocaine 7%, tetracaine 7%; emulsion cream.

Company:
Taro Pharmaceuticals

Therapeutic Use:

Indications for PLIAGLIS:

Local analgesia for superficial dermatological procedures (eg, dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, laser-assisted tattoo removal).

Adult:

Do not exceed recommended dose or duration. Apply to intact skin prior to procedure; spread evenly and thinly across treatment area using a metal spatula or tongue depressor. Dermal filler inj or facial laser ablation: apply for 20–30mins. Laser-assisted tattoo removal: apply for 60mins. Amount (length) to apply: see full labeling.

Children:

Not established.

Contraindications:

PABA hypersensitivity.

Warnings/Precautions:

Risk of methemoglobinemia (esp. in G6PD deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6 months of age, concurrent exposure to oxidizing agents or metabolites); monitor. Avoid overexposure. Severe hepatic disease. Pseudocholinesterase deficiency. Risks of secondary exposure to children and pets; may be toxic. Avoid contact with eyes, mucous membranes, or areas with a compromised skin barrier (eg, broken or inflamed). Acutely ill. Debilitated. Elderly. Pregnancy. Nursing mothers.

Pharmacological Class:

Topical anesthetic (amide-type + ester-type).

Interactions:

Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, others. Toxicity may be potentiated by Class I antiarrhythmics (eg, tocainide, mexiletine); caution. Additive effects with other products containing local anesthetics; consider the amount absorbed from all formulations.

Adverse Reactions:

Localized reactions (eg, erythema, skin discoloration, edema), allergic reactions (eg, urticaria, angioedema, bronchospasm, shock).

Metabolism:

Lidocaine: hepatic.

Elimination:

Lidocaine: renal.

Generic Availability:

NO

How Supplied:

Cream—30g

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