Generic Name and Formulations:
Cilostazol 50mg, 100mg; tabs.
Various generic manufacturers
Indications for Cilostazol:
100mg twice daily, ½ hr before or 2 hrs after breakfast and dinner. May reduce to 50mg twice daily if used with CYP3A4 or CYP2C19 inhibitors.
Heart failure of any severity.
Contraindicated in heart failure patients.
Risk of tachycardia, palpitation, tachyarrhythmia, or hypotension. Risk of exacerbations of angina pectoris or MI in patients with history of ischemic heart disease. LV outflow tract obstruction: monitor for development of a new systolic murmur or cardiac symptoms. Monitor platelets and WBC periodically. Avoid use in hemostatic disorders or active pathologic bleeding. Moderate-to-severe hepatic impairment. Severe renal impairment. Dialysis. Pregnancy (Cat.C). Nursing mothers: not recommended.
Phosphodiesterase 3 (PDE3) inhibitor.
Potentiated by drugs that inhibit CYP3A4 (eg, azole antifungals, macrolides, diltiazem, protease inhibitors) or CYP2C19 (eg, omeprazole, fluconazole, fluoxetine, ticlopidine). Avoid grapefruit juice. Cilostazol has been used with aspirin; caution with other antiplatelets, anticoagulants.
Headache, diarrhea, abnormal stools, palpitations, peripheral edema, dizziness, pharyngitis, infection, tachycardia; rare: thrombocytopenia, leukopenia.
Clinical Pain Advisor Articles
- Manual Therapy vs Opioids for Management of Shoulder, Spine Pain
- Kinesiophobia May Be Associated With Greater Cutaneous Allodynia in Migraine
- Intervention by Pharmacists May Effectively Reduce Use of Inappropriate Medications in the Elderly
- PainDETECT May Not Be Optimal to Detect Neuropathic Components of Orofacial Pain
- Topical Migraine Trigger Point Treatment as Effective as Injection
- Serum Vitamin D Levels and Risk for Migraine
- Rimegepant Orally Dissolving Formulation Provides Rapid Relief From Acute Migraine
- Updated Evidence-Based Recommendations for Buprenorphine Treatment
- Prescription Digital Therapeutic Approved for Opioid Use Disorder
- Persistence of Post-Traumatic CRPS Associated With Initial Pain Sensitization
- Blunted Cardiovascular Stress Reactivity in Fibromyalgia With Comorbid PTSD
- Name-Brand Medications Driving Spike in U.S. Drug Spending
- Physician Responsibility to Combat "Fake News" in Medicine
- The Future Of Robot Physicians: Is Artificial Intelligence Poised to Take Over Medicine?
- Chronic Spinal Pain and Depression: Does One Represent a Risk Factor for the Other?