Osteoarthritis

Positive Phase 3 Results for Novel OA Pain Treatment Tanezumab

Positive Phase 3 Results for Novel OA Pain Treatment Tanezumab

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The 16-week, double-blind, placebo-controlled, multicenter, parallel-group study included 698 patients who were randomized to 3 treatment groups: 2 doses of tanezumab 2.5mg; 1 dose of tanezumab 2.5mg followed by tanezumab 5mg, or 2 doses of placebo; each injection was administered once every 8 weeks.

New Recommendations Guide Arthritis Pain Management

New Recommendations Guide Arthritis Pain Management

Patient-centered recommendations released by the European League Against Rheumatism

Consensi Approved to Treat Hypertension and Osteoarthritis Pain

Consensi Approved to Treat Hypertension and Osteoarthritis Pain

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Consensi combines amlodipine besylate, a calcium-channel blocker (CCB), and celecoxib, a nonsteroidal anti-inflammatory drug (NSAID).

Risks Associated With Co-Administration of Aspirin and Other NSAIDs

Risks Associated With Co-Administration of Aspirin and Other NSAIDs

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In patients with rheumatoid arthritis or osteoarthritis who are at higher risk for cardiovascular events, celecoxib may be safer compared with naproxen or ibuprofen when these drugs are taken alone or in combination with aspirin.

EULAR Releases Recommendations for Pain Management in OA, Inflammatory Arthritis

EULAR Releases Recommendations for Pain Management in OA, Inflammatory Arthritis

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EULAR has released recommendations to enable health professionals to provide knowledgeable pain management support for patients with inflammatory arthritis and osteoarthritis.

Zilretta Benefits 'Real-World' Patients With Knee OA, Says Study

Zilretta Benefits 'Real-World' Patients With Knee OA, Says Study

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Patients who received a repeat Zilretta injection experienced a 64% improvement in Western Ontario and McMaster Universities Arthritis Index (WOMAC)-A (pain), a 66% improvement in WOMAC-B (stiffness), a 64% improvement on WOMAC-C (function), and improvement represented by a doubling of the KOOS Quality of Life subscale score by Week 4.

GI Safety Compared for NSAIDs in Patients With Arthritis

GI Safety Compared for NSAIDs in Patients With Arthritis

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The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Intramuscular Triamcinolone Acetate Injection for OA Hip Pain

Intramuscular Triamcinolone Acetate Injection for OA Hip Pain

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In patients with painful hip osteoarthritis, an intramuscular glucocorticoid injection may effectively alleviate hip pain in the short-term.

Incidence of Musculoskeletal Disorders, Depression in Migraine

Incidence of Musculoskeletal Disorders, Depression in Migraine

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Fibromyalgia, osteoarthritis, sciatic syndrome, rheumatoid arthritis, and moderate depression may be more prevalent in working-age individuals with vs without migraine.

Bariatric Surgery Lessens Knee OA Pain More in Certain Patients

Bariatric Surgery Lessens Knee OA Pain More in Certain Patients

Laparoscopic gastric band surgery is associated with more improvement in knee osteoarthritis in younger patients and those without prior knee injury.

Subcutaneous vs Intravenous Tanezumab for Knee, Hip Osteoarthritis

Subcutaneous vs Intravenous Tanezumab for Knee, Hip Osteoarthritis

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Intravenous and subcutaneous administration of tanezumab may provide similar analgesia and tolerability in patients with hip or knee osteoarthritis.

Durolane Now Available to Treat Knee Osteoarthritis Pain

Durolane Now Available to Treat Knee Osteoarthritis Pain

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In clinical trials, treatment with Durolane resulted in greater reduction in Visual Analog Scale (VAS) pain scores at 3 and 6 months compared to Synvisc One (hylan G-F 20; Sanofi Genzyme).

Radiofrequency Ablation for Chronic Hip Pain: Reviewing the Evidence

Radiofrequency Ablation for Chronic Hip Pain: Reviewing the Evidence

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The available evidence suggests that radiofrequency ablation is a feasible treatment option for chronic hip pain associated with degenerative diseases.

Opioids vs Nonopioid Medications for Chronic Back, Knee, and Hip Osteoarthritis Pain

Opioids vs Nonopioid Medications for Chronic Back, Knee, and Hip Osteoarthritis Pain

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Opioids and nonopioid analgesics were found to provide similar improvements in pain-related function over a 1-year period in patients with chronic back pain or knee or hip osteoarthritis pain.

Glucosamine vs Ibuprofen for Painful Temporomandibular Joint Osteoarthritis

Glucosamine vs Ibuprofen for Painful Temporomandibular Joint Osteoarthritis

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The effects of glucosamine supplements in the treatment of patients with painful temporomandibular joint osteoarthritis were not superior to the effects of ibuprofen taken 2 to 3 times per day.

Osteoarthritis-Associated Pain Not Relieved With Hydroxychloroquine

Osteoarthritis-Associated Pain Not Relieved With Hydroxychloroquine

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Hydroxychloroquine was no more effective than placebo in reducing symptoms or radiographic progression in patients with moderate to severe hand pain and radiographic osteoarthritis.

Predictive Value of Genicular Nerve Blocks for Outcomes of Cooled Radiofrequency Ablation

Predictive Value of Genicular Nerve Blocks for Outcomes of Cooled Radiofrequency Ablation

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Pain relief of at least 50% following a prognostic genicular nerve block may not predict pain relief following genicular nerve cooled radiofrequency ablation in patients with chronic knee pain due to osteoarthritis.

Knee Pain in Osteoarthritis Associated With Long-Term Prefrailty, Frailty

Knee Pain in Osteoarthritis Associated With Long-Term Prefrailty, Frailty

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Unilateral and bilateral knee pain may be associated with development of prefrailty and frailty over 6 years.

Joint and Back Pain May Not Be Associated With Rainfall

Joint and Back Pain May Not Be Associated With Rainfall

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Rainfall may not be associated with joint or back pain in older Medicare beneficiaries.

Substantial Weight Loss Associated With Reduced Cartilage Degeneration in Osteoarthritis

Substantial Weight Loss Associated With Reduced Cartilage Degeneration in Osteoarthritis

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Patients with osteoarthritis who achieved a >10% weight loss were found to have reduced cartilage degeneration, compared with patients achieving only moderate or no weight loss.

Short- vs Long-Acting Opioids for Osteoarthritis Pain

Short- vs Long-Acting Opioids for Osteoarthritis Pain

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In addition to being safer and more cost-effective, short-acting opioids are comparable with long-acting opioids for pain management in patients with chronic osteoarthritis.

Vibrating Gloves Significantly Reduce Osteoarthritis-Related Hand Pain

Vibrating Gloves Significantly Reduce Osteoarthritis-Related Hand Pain

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Gloves with small vibrating motors may safely reduce hand pain among women with osteoarthritis during and after use.

Durolane Approved for Treatment of Osteoarthritis Knee Pain

Durolane Approved for Treatment of Osteoarthritis Knee Pain

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The FDA has approved Durolane for the treatment of pain associated with knee osteoarthritis, which relieved pain and restored function for up to 6 months in patients.

Paracetamol Superior to Placebo for Osteoarthritis Knee Pain

Paracetamol Superior to Placebo for Osteoarthritis Knee Pain

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Extended-release paracetamol may have a greater analgesic effect than placebo in patients with osteoarthritic knee pain.

Is Hand Osteoarthritis Associated With BMI, Smoking, or Alcohol Consumption?

Is Hand Osteoarthritis Associated With BMI, Smoking, or Alcohol Consumption?

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Researchers examined alcohol consumption, smoking status, and body mass index as variables impacting patients' risk of osteoarthritis development or progression.

Pros and Cons of Early Antiretroviral Therapy Initiation

Pros and Cons of Early Antiretroviral Therapy Initiation

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Patients with HIV who underwent immediate ART saw significant decreases in bone mineral density; however, the benefits of beginning ART early outweigh the outcomes related to decreased BMD.

Risk of Hip Arthoplasty in Men Increased with Dairy Product Consumption

Risk of Hip Arthoplasty in Men Increased with Dairy Product Consumption

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Consuming more dairy product may raise the risk for total hip arthroplasty for osteoarthritis in men.

Diclofenac is the Most Effective NSAID in Reducing Osteoarthritic Pain

Diclofenac is the Most Effective NSAID in Reducing Osteoarthritic Pain

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Diclofenac at 150 mg/day is the most effective NSAID for treating osteoarthritic pain and physical disability, while paracetamol had nearly no effect.

Mobility Barriers' Impact on Daily Life of Patients With Knee Osteoarthritis

Mobility Barriers' Impact on Daily Life of Patients With Knee Osteoarthritis

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Approximately 37% of US adults aged 60 years and older have been diagnosed with knee osteoarthritis, and the number is expected to rise.

Positive Psychological Intervention Effective on Osteoarthritis

Positive Psychological Intervention Effective on Osteoarthritis

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Positive psychosocial interventions improved symptom severity, quality of life, and mood in Veteran Administration patients with osteoarthritis of the hip and knee.

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