Opioids

Intrathecal Drug Delivery Systems May Be Ineffective for Complex Regional Pain Syndrome

Intrathecal Drug Delivery Systems May Be Ineffective for Complex Regional Pain Syndrome

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Intrathecal drug delivery systems may be ineffective in reducing pain and oral opioid intake in individuals with complex regional pain syndrome.

Opioid, Nonopioid Utilization Management for Low Back Pain Prevalent in Major Health Plans

Opioid, Nonopioid Utilization Management for Low Back Pain Prevalent in Major Health Plans

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Utilization management strategies for opioid and nonopioid medications in low back pain, including quantity limits and prior authorization, were found to be commonly used in Medicaid, Medicare Advantage, and commercial insurance plans.

Mixing Sedative-Hypnotics, Prescription Opioids Associated With Suicidal Ideation in Serious Mental Illness

Mixing Sedative-Hypnotics, Prescription Opioids Associated With Suicidal Ideation in Serious Mental Illness

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Concurrent use of sedative-hypnotic and prescription opioid medications may increase the risk for suicidal ideation in individuals with serious mental illness.

Parenteral Opioids May Be Effective for Reducing Pain During Childbirth According to Cochrane Review

Parenteral Opioids May Be Effective for Reducing Pain During Childbirth According to Cochrane Review

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The use of parenteral opioid medications may be supported for effective pain relief during labor.

Reproductive Dysfunction Risk in Women Taking Long-Term Opioids for Musculoskeletal Pain

Reproductive Dysfunction Risk in Women Taking Long-Term Opioids for Musculoskeletal Pain

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Women prescribed long- vs short-term opioids for chronic musculoskeletal pain may be at increased risk for menopause and abnormal menstruation.

Overdose Risk Highest in First Days of Concurrent Opioid, Benzodiazepine Use

Overdose Risk Highest in First Days of Concurrent Opioid, Benzodiazepine Use

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

Recommendations for Perioperative Pain Management in Patients With Opioid Tolerance

Recommendations for Perioperative Pain Management in Patients With Opioid Tolerance

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With the increasing number of patients presenting to surgery with opioid tolerance, clinicians should be familiar with their specific analgesic needs.

Dispositional Mindfulness May Reduce Opioid Misuse in Chronic Pain

Dispositional Mindfulness May Reduce Opioid Misuse in Chronic Pain

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Dispositional mindfulness may help reduce the risk for opioid misuse in patients with chronic pain by attenuating opioid craving and directing attention to naturally rewarding stimuli.

Mandatory PDMP for Prescribers Lowers Opioid Dispensing Rate

Mandatory PDMP for Prescribers Lowers Opioid Dispensing Rate

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Legislation that requires prescribers to check Ohio's Prescription Drug Monitoring Program was found to lead to a reduction in the quantity of opioids and benzodiazepines dispensed.

Studies ID Impact of U.S. Opioid-Related Mortality, Rx Patterns

Studies ID Impact of U.S. Opioid-Related Mortality, Rx Patterns

From 2001 to 2016 there was an increase in the number and percentage of opioid-related deaths; in addition, most patients receiving opioids receive immediate-release formulations.

Two Lots of Naloxone Hydrochloride Carpuject Injections Recalled

Two Lots of Naloxone Hydrochloride Carpuject Injections Recalled

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Two lots of naloxone hydrochloride injections, USP have been recalled by Hospira, Inc., due to concerns regarding the presence of particulates on the syringe plunger.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

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A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Global Prevalence of Alcohol, Tobacco, and Illicit Drug Use: A 2017 Status Report

Global Prevalence of Alcohol, Tobacco, and Illicit Drug Use: A 2017 Status Report

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Researchers proposed that future projects investigate the geographical and temporal trends in substance use and its disease burden.

Years of Life Lost and Fatal Drug Overdoses

Years of Life Lost and Fatal Drug Overdoses

Researchers used vital statistics data to examine whether increases in mortality rates and years of potential life lost among midlife non-Hispanic whites from 1999 to 2015 are associated with increases in fatal overdoses.

Opioid Education Program Boosts PA Students' Confidence in Providing Patient Care

Opioid Education Program Boosts PA Students' Confidence in Providing Patient Care

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PA students perceived improved confidence in their ability to provide patient education and counseling.

Opioid-Related Adverse Drug Events Associated With Worse Patient, Cost Outcomes

Opioid-Related Adverse Drug Events Associated With Worse Patient, Cost Outcomes

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Adverse events associated with opioids administered for the management of postsurgical and postendoscopy pain may be associated with worse cost and patient outcomes.

Practice Intervention Targeting IV Opioids May Cut Exposure

Practice Intervention Targeting IV Opioids May Cut Exposure

Opioid use was compared between a six-month control period and three months following education for prescribers on opioid administration routes, focusing on awareness of the subcutaneous routes.

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

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Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.

Opioid-Related Payments Linked to Increase in Opioid Prescriptions

Opioid-Related Payments Linked to Increase in Opioid Prescriptions

Researchers examined the extent to which pharmaceutical industry marketing of opioid products to physicians during 2014 correlated with opioid prescribing in 2015.

Opioid Use in Chronic Low Back Pain: A Population Study

Opioid Use in Chronic Low Back Pain: A Population Study

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The most common prescription drug in US adults with chronic low back pain are opioids.

Opioids in Setting of Hemodialysis Associated With Adverse Events

Opioids in Setting of Hemodialysis Associated With Adverse Events

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Opioids were found to be associated with adverse events in older Medicare beneficiaries on hemodialysis.

Opioids Often Over-Prescribed After Hiatal Hernia Surgery

Opioids Often Over-Prescribed After Hiatal Hernia Surgery

The researchers found that the median prescription size was 350 mg oral morphine equivalents and median patient use was 225 mg oral morphine equivalents following open hiatal hernia repair.

Exposure to Opioids in the ICU May Not Be Associated With Persistent Pain

Exposure to Opioids in the ICU May Not Be Associated With Persistent Pain

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Persistent pain — which is common in survivors of critical illnesses — may not be associated with opioid exposure during intensive care unit stay.

Lofexidine Effective for Opioid Withdrawal Symptoms

Lofexidine Effective for Opioid Withdrawal Symptoms

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Investigators pooled data from 2 phase 3 placebo-controlled studies to evaluate the safety and efficacy of lofexidine for opioid withdrawal symptoms.

Walmart Plans on Restricting Supply on Acute Opioid Prescription Fills

Walmart Plans on Restricting Supply on Acute Opioid Prescription Fills

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For states that currently limit new acute opioid prescription fills to <7 days, Walmart and Sam's Club pharmacies will follow that state law.

Effect of Prescription Drug Monitoring Programs on Fatal, Nonfatal Drug Overdoses

Effect of Prescription Drug Monitoring Programs on Fatal, Nonfatal Drug Overdoses

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Evidence allowing us to assess the benefits of and risks associated with prescription drug monitoring programs is insufficient.

Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug Users

Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug Users

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The investigators suggest that enrollment in a methadone maintenance therapy program may be helpful in providing access to HCV care in people who inject drugs.

Opioid Use After Elective Surgery Quantified

Opioid Use After Elective Surgery Quantified

Researchers conducted a prospective survey of patients to investigate postoperative opioid use.

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide Rate

The researchers note that patients with chronic pain and those with mood disorders are more likely to receive opioid prescriptions and are also at greater risk for suicide.

Sources of Misused Opioids in Older Adults

Sources of Misused Opioids in Older Adults

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Recent physician-prescribed opioids represent the main source of provenance of the drug in individuals age ≥65 years who misuse them.

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