Lofexidine may help patients with opioid withdrawal symptoms or difficulty with opioid discontinuation.
Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.
If approved, Lucemyra will be the first non-opioid medication indicated to mitigate opioid withdrawal symptoms.
The proposal addresses inappropriate ICD-10-CM coding options for withdrawal from opioids, sedatives, or stimulants.
US WorldMeds announced that the Food and Drug Administration has accepted for Priority Review the New Drug Application for lofexidine to manage the symptoms associated with opioid withdrawal and to facilitate completion of opioid discontinuation treatment.
The extended-release formulation of tramadol was shown to be as effective as buprenorphine and more effective than clonidine for treating symptoms of opioid withdrawal.
The DEA's plan to list kratom as a Schedule I controlled substance would make researching the possible opioid substitute much more difficult.
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