Opioid Dependence

Identification of Active-State Kappa-Opioid Receptor Crystal Structure May Facilitate the Design of Improved Analgesics

Identification of Active-State Kappa-Opioid Receptor Crystal Structure May Facilitate the Design of Improved Analgesics

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Elucidation of the crystal structure of κ-opioid receptors in their active state may facilitate the design of optimized analgesics, devoid of psychoactive effects and of addictive properties.

Extended-Release Naltrexone Injections Reduce Opioid Dependence

Extended-Release Naltrexone Injections Reduce Opioid Dependence

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Compared with buprenorphine-naloxone, use of extended-release naltrexone maintained abstinence from heroin and other illicit substances at a similar rate.

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

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Changes in several measures of pain in patients suspected of opioid-induced hyperalgesia were observed after transitioning from opioids to buprenorphine.

Initial Opioid Prescription May Affect Long-Term Use

Initial Opioid Prescription May Affect Long-Term Use

Doctors who limit the supply of opioids they prescribe to 3 days or less may help patients reduce their risk of dependence and addiction.

Naltrexone vs Buprenorphine to Treat Opioid Dependence

Naltrexone vs Buprenorphine to Treat Opioid Dependence

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An 8-day detoxification process using low-dose oral naltrexone showed superior efficacy to the standard 15-day approach that uses an agonist taper leading to induction with extended-release naltrexone

Effectiveness of Subdermal Buprenorphine Implants in Maintaining Opioid Abstinence

Effectiveness of Subdermal Buprenorphine Implants in Maintaining Opioid Abstinence

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Buprenorphine implants could help improve relapse prevention in patients who are currently maintaining abstinence with sublingual buprenorphine

FDA Approves Implantable Device for Steady Release of Buprenorphine

FDA Approves Implantable Device for Steady Release of Buprenorphine

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Improved delivery method for buprenorphine

ER Naltrexone Associated With Lower Rate of Opioid Relapse

ER Naltrexone Associated With Lower Rate of Opioid Relapse

Lower rate of relapse compared with usual treatment in trial involving criminal justice offenders.

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