Opioid Analgesics

Identification of Active-State Kappa-Opioid Receptor Crystal Structure May Facilitate the Design of Improved Analgesics

Identification of Active-State Kappa-Opioid Receptor Crystal Structure May Facilitate the Design of Improved Analgesics

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Elucidation of the crystal structure of κ-opioid receptors in their active state may facilitate the design of optimized analgesics, devoid of psychoactive effects and of addictive properties.

Preoperative Opioid Use Significantly Impacts Postoperative Opioid Course

Preoperative Opioid Use Significantly Impacts Postoperative Opioid Course

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Preoperative opioid use is a better predictor for prolonged postoperative opioid use than pain, substance abuse, and affective disorder.

Feast or Famine: The World's Opioid Gap

Feast or Famine: The World's Opioid Gap

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Much of the third world is suffering in pain without access to opioids. This imbalance has been called the opioid gap. How can we get opioids to patients who need them?

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