The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.
Fifteen percent of adults who took ibuprofen during a 1-week diary study exceeded the maximum recommended daily dose limit.
Diclofenac at 150 mg/day is the most effective NSAID for treating osteoarthritic pain and physical disability, while paracetamol had nearly no effect.
Opioids prescribed for pain following a motor vehicle collision do not reduce the likelihood of developing persistent pain.
Cognitive behavioral therapy is an effective nonpharmacologic treatment that should be considered as a first-line therapy for pediatric migraine.
About 1 in 5 NSAID adverse drug reactions is a hypersensitivity reaction.
Clinical Pain Advisor Articles
- History of Migraine May Be Associated With Higher Risk for Cochlear Disorders
- Symptom Severity, Sensory Sensitivity May Indicate Pain Centralization in Chronic Overlapping Pain Conditions
- Radiofrequency Denervation Efficacious in Treating Thoracic Zygapophyseal Joint Pain
- Stat Consult: Chronic Low Back Pain
- Opioid Misuse May Help Predict Alcohol Dependence Treatment Outcomes
- Consensus Guidelines for the Use of Intravenous Ketamine for Chronic Pain
- Pain Societies Issue Guidelines on Use of Ketamine for the Management of Acute Pain
- Labor Epidural Analgesia Linked to Reduced Likelihood of Successful Breastfeeding
- Novel Oral Treatment Safe, Effective for Migraine Headache Relief
- DFN-02 Nasal Spray Safe, Effective for Acute Treatment of Episodic Migraine
- Predictors of Opioid Overdose in High-Risk Users
- FDA to Review Long-Acting Treatment for Opioid Use Disorder
- Half of Patients Referred for Behavioral Treatment of Migraine Never Initiate Treatment
- Low-Dose Sumatriptan Injection Effective as Acute Migraine Treatment
- The Fight for Patient Privacy Under Big Data Analytics