The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.
Fifteen percent of adults who took ibuprofen during a 1-week diary study exceeded the maximum recommended daily dose limit.
Diclofenac at 150 mg/day is the most effective NSAID for treating osteoarthritic pain and physical disability, while paracetamol had nearly no effect.
Opioids prescribed for pain following a motor vehicle collision do not reduce the likelihood of developing persistent pain.
Cognitive behavioral therapy is an effective nonpharmacologic treatment that should be considered as a first-line therapy for pediatric migraine.
About 1 in 5 NSAID adverse drug reactions is a hypersensitivity reaction.
Clinical Pain Advisor Articles
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- FDA Outlines Plan for New Analgesic Guidance to Combat Opioid Crisis
- The Role of Psychological Factors in Phantom Limb Pain Reviewed
- Rates of Concurrent Opioid, Sedative-Hypnotic Prescription Fills in Veterans
- Ozone vs Corticosteroids May Provide Longer-Lasting Effects for Plantar Fasciitis
- Ketamine: Mechanisms of Action, Uses in Pain Medicine, and Side Effects
- Medicinal Cannabis May Not Have Opioid-Sparing Effects in Chronic Noncancer Pain
- Cannabis May Be Effective for Migraine Treatment
- Integrating Psychological Interventions Into Chronic Pain Management
- Chronic Neck Pain: Generators, Clinical Examination, MRI Findings, and Differential Diagnosis
- Pregabalin May Not Improve Analgesia During Medical Abortion
- Investigational Treatment Shows Promise in Chronic Low Back Pain
- Rheumatologist-Assessed vs Criteria for Inflammatory Back Pain in Psoriatic Arthritis
- Incorporating Guidelines Into Clinical Practice: An Interview With Gary L. LeRoy, MD
- Pain Severity May Partly Mediate the Association Between Depression and Physical Performance in Knee OA