Nonsteroidal Anti-Inflammatory Drugs

Risks Associated With Co-Administration of Aspirin and Other NSAIDs

Risks Associated With Co-Administration of Aspirin and Other NSAIDs

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In patients with rheumatoid arthritis or osteoarthritis who are at higher risk for cardiovascular events, celecoxib may be safer compared with naproxen or ibuprofen when these drugs are taken alone or in combination with aspirin.

Evaluating Analgesic Benefits of NSAID Combinations for Acute Postoperative Dental Pain

Evaluating Analgesic Benefits of NSAID Combinations for Acute Postoperative Dental Pain

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Acetaminophen in combination with ibuprofen or oxycodone, as well as diclofenac, and flurbiprofen may offer more effective analgesia for acute postoperative dental pain in adults.

GI Safety Compared for NSAIDs in Patients With Arthritis

GI Safety Compared for NSAIDs in Patients With Arthritis

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The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

Corticosteroids May Be an Effective Alternative to NSAIDs in Acute Gout Pain

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Corticosteroids appear to be a reasonable alternative to NSAIDs for the treatment of acute pain as a result of gout.

Glucosamine vs Ibuprofen for Painful Temporomandibular Joint Osteoarthritis

Glucosamine vs Ibuprofen for Painful Temporomandibular Joint Osteoarthritis

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The effects of glucosamine supplements in the treatment of patients with painful temporomandibular joint osteoarthritis were not superior to the effects of ibuprofen taken 2 to 3 times per day.

Evaluating Excessive NSAID Use in Ibuprofen Users

Evaluating Excessive NSAID Use in Ibuprofen Users

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Fifteen percent of adults who took ibuprofen during a 1-week diary study exceeded the maximum recommended daily dose limit.

Evaluating Excessive NSAID Use in Ibuprofen Users

Evaluating Excessive NSAID Use in Ibuprofen Users

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Fifteen percent of adults who took ibuprofen during a 1-week diary study exceeded the maximum recommended daily dose limit.

Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity Pain

Nonopioid Analgesic Combination and Opioid Combinations Provide Similar Analgesic Effects for Acute Extremity Pain

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Nonopioid analgesic combinations may be noninferior to opioid/acetaminophen combinations for reducing acute extremity pain.

Ibuprofen Comparable With Morphine for Postoperative Pain in Children

Ibuprofen Comparable With Morphine for Postoperative Pain in Children

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Among children who have undergone minor outpatient orthopedic surgery, ibuprofen provides equivalent postoperative pain relief compared with oral morphine.

Low-Dose Oromucosal Ibuprofen Effective for Relieving Sore Throat

Low-Dose Oromucosal Ibuprofen Effective for Relieving Sore Throat

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The repeated dosing of 25 mg low-dose oromucosal ibuprofen provides greater and more rapid pain relief for non-streptococcal sore throat pain than placebo.

Safety Guidelines Issued for Use of RA Drugs During Pregnancy and Lactation

Safety Guidelines Issued for Use of RA Drugs During Pregnancy and Lactation

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Although a majority of women with rheumatoid arthritis were previously though to achieve remission during pregnancy, recent studies indicate remission occurs in only 20% to 40% of cases.

Diclofenac is the Most Effective NSAID in Reducing Osteoarthritic Pain

Diclofenac is the Most Effective NSAID in Reducing Osteoarthritic Pain

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Diclofenac at 150 mg/day is the most effective NSAID for treating osteoarthritic pain and physical disability, while paracetamol had nearly no effect.

Acetaminophen, Ibuprofen Often Under-Dosed in Children in the ED

Acetaminophen, Ibuprofen Often Under-Dosed in Children in the ED

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Acetaminophen and ibuprofen are frequently under-dosed in children in the emergency department.

Managing Spinal Pain With NSAIDs?

Managing Spinal Pain With NSAIDs?

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Meta-analysis indicates short-term NSAID use is generally safe and can relieve pain, but lacks clinically important benefits.

Optimal Management of Post-mastectomy Pain Syndrome

Optimal Management of Post-mastectomy Pain Syndrome

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Limited data suggest antidepressants, topical capsaicin, and fat grafting may reduce pain associated with post-mastectomy pain syndrome, but more and better studies are needed to determine optimal management for this debilitating condition.

Little Benefits of NSAIDs for Back Pain

Little Benefits of NSAIDs for Back Pain

NSAIDs do not help most patients with back pain, according to a review published in the Annals of the Rheumatic Diseases.

Opioids vs NSAIDs Following Motor Vehicle Collision

Opioids vs NSAIDs Following Motor Vehicle Collision

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Opioids prescribed for pain following a motor vehicle collision do not reduce the likelihood of developing persistent pain.

Cognitive Behavioral Therapy as First-Line Therapy for Pediatric Migraine

Cognitive Behavioral Therapy as First-Line Therapy for Pediatric Migraine

Cognitive behavioral therapy is an effective nonpharmacologic treatment that should be considered as a first-line therapy for pediatric migraine.

Hypersensitivity to NSAIDs: Risk Factors

Hypersensitivity to NSAIDs: Risk Factors

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About 1 in 5 NSAID adverse drug reactions is a hypersensitivity reaction.

Comparing Cardiovascular Risk of Arthritis Medications

Comparing Cardiovascular Risk of Arthritis Medications

Celecoxib is comparable to naproxen and ibuprofen in cardiovascular safety for patients with arthritis at high risk for cardiovascular disease.

Novel Treatment Options for Managing Pain in the Emergency Department

Novel Treatment Options for Managing Pain in the Emergency Department

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Physicians who want to prescribe alternatives for pain management should familiarize themselves with current research.

CDC: Aspirin Use Common Among Americans With Heart Disease

CDC: Aspirin Use Common Among Americans With Heart Disease

Clinical and community-based approaches should be used to increase aspirin use among low-use groups.

Antidepressant, Painkiller Combination May Raise Risk Of Intracranial Hemorrhage

Antidepressant, Painkiller Combination May Raise Risk Of Intracranial Hemorrhage

No indication any particular type of antidepressant carries a greater risk than others.

Coronary Artery Disease Ups Risk of Bowel Bleeds With NSAIDs

Coronary Artery Disease Ups Risk of Bowel Bleeds With NSAIDs

Co-use of thienopyridine and prior use of rebamipide also up risk.

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