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NITROSTAT
Angina
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Drug Name:

NITROSTAT Rx

Generic Name and Formulations:
Nitroglycerin 0.3mg, 0.4mg, 0.6mg; sublingual tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for NITROSTAT:

Acute relief of angina attack. Acute prophylaxis of angina pectoris.

Adult:

Use lowest effective dose. Treatment: 1 tab sublingually or in buccal pouch at onset, may repeat in 5mins; max 3 tabs in 15mins. Prophylaxis: 5–10mins before activity.

Children:

Not established.

Contraindications:

Severe anemia. Increased intracranial pressure (eg, cerebral hemorrhage, traumatic brain injury). Acute circulatory failure or shock. Concomitant PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil), soluble guanylate cyclase stimulators (eg, riociguat).

Warnings/Precautions:

Constrictive pericarditis, aortic or mitral stenosis, volume-depleted, hypotensive: increased risk of severe hypotension. Hypertrophic cardiomyopathy. Elderly. Pregnancy. Nursing mothers: not studied.

Interactions:

See Contraindications. Hypotension potentiated by PDE-5 inhibitors, riociguat. Avoid ergotamine and related drugs.

Pharmacological Class:

Nitrate.

Adverse Reactions:

Headache, dizziness, paresthesia, vertigo, weakness, palpitation, postural hypotension, syncope, flushing, rash, exfoliative dermatitis.

How Supplied:

Tabs 0.4mg—4 x 25, 100; 0.3mg, 0.6mg—100

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