Generic Name and Formulations:
Nilutamide 150mg; tabs.
Concordia Pharmaceuticals Inc.
Indications for NILANDRON:
Metastatic prostate cancer (Stage D2), as an adjunct to surgical castration.
300mg once daily for 30 days then 150mg once daily, starting day of or day after surgical castration.
Severe hepatic impairment or respiratory insufficiency.
Obtain baseline liver and pulmonary function tests, routine chest X-ray. Monitor for interstitial pneumonitis; discontinue if symptoms occur. Monitor liver function for first 4 months then periodically; discontinue if ALT > 2xULN or jaundice occurs. May discolor urine or sclera. Pregnancy (not for use in women). Nursing mothers.
Monitor drugs metabolized by CYP450 (eg, Vit. K antagonists, theophylline, phenytoin); may need to adjust dose. May cause alcohol intolerance.
Hot flushes, impaired night vision, GI upset, increased liver enzymes, constipation, dizziness, abnormal vision, hypertension, hepatitis, interstitial pneumonitis.
Clinical Pain Advisor Articles
- Notifications by PDMPs May Not Effectively Reduce Opioid Misuse
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Electroacupuncture May Help Reduce Opioid Use in Chronic Musculoskeletal Pain
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- The Challenge of Compassion in Modern Healthcare Settings
- Republican Opposition to Obamacare: What's Done, What's to Come
- Lowering Default Pill Counts in EMRs May Effectively Reduce Postoperative Opioid Prescription Numbers
- Steps Taken to Increase Use of Electronic Tools in Medicine
- Daily and Retrospective Pain Measurements Comparable in Hip Osteoarthritis