Neuropathic Pain

Short Segment Sensory Nerve Stimulation Offers Potential Diagnostic Value for Ulnar Neuropathy

Short Segment Sensory Nerve Stimulation Offers Potential Diagnostic Value for Ulnar Neuropathy

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The use of short-segment stimulation along the ulnar sensory nerves and across the elbow may provide reliable diagnostic confirmation of ulnar neuropathies.

Menopausal Hormone Therapy May Reduce Carpal Tunnel Syndrome Risk

Menopausal Hormone Therapy May Reduce Carpal Tunnel Syndrome Risk

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To investigate the association between hormone therapy and carpal tunnel syndrome risk, researchers conducted a secondary analysis of the Women's Health Initiative (WHI) hormone therapy trials.

Central Risk Factors May Contribute to Neuropathic-Like Knee Pain

Central Risk Factors May Contribute to Neuropathic-Like Knee Pain

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Neuropathic-like knee pain may be driven by central risk factors that include depression, anxiety, and pain catastrophizing.

FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

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The treatment is currently being evaluated in a Phase 2 study (ELEVATE) in patients with major depressive disorder who have had an inadequate response to standard antidepressant therapy.

Predicting Success of Focal Nerve Surgery Based on Diagnostic Block Response

Predicting Success of Focal Nerve Surgery Based on Diagnostic Block Response

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The efficacy of a diagnostic nerve block may be a poor predictor of the success of surgery for focal nerve injury.

Altered Brain Connectivity Patterns Associated With THC-Induced Analgesia

Altered Brain Connectivity Patterns Associated With THC-Induced Analgesia

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A reduction in the functional connectivity between the sensorimotor cortex and the anterior cingulate cortex and dorsolateral prefrontal cortex may be associated with δ-9-tetrahydrocannabinol-associated analgesia in patients with chronic radicular neuropathic pain.

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

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The primary outcome measure was pain rated in a diary completed by telephone each evening; secondary outcomes included measures of overall status, pain-related activity limitation, and sleep.

ZTlido Patch for Post-Shingles Pain Launching Soon

ZTlido Patch for Post-Shingles Pain Launching Soon

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The non-aqueous adhesive patch requires 36mg per topical system to achieve the same therapeutic dose as Lidoderm (lidocaine 5%) which contains 700mg per patch.

Neuropathic Pain Medications

Chart with medications used to treat neuropathic pain, including diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKR

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Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.

Neuropathic Symptoms Worsen Quality of Life, Function in Hip, Knee Osteoarthritis

Neuropathic Symptoms Worsen Quality of Life, Function in Hip, Knee Osteoarthritis

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Neuropathic-like symptoms may affect pain-related quality of life ratings and function in patients with hip and knee osteoarthritis, respectively.

Sustained-Release Sodium Nitrite for Diabetic Neuropathic Pain Not Associated With Headaches

Sustained-Release Sodium Nitrite for Diabetic Neuropathic Pain Not Associated With Headaches

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A sustained-release formulation of sodium nitrite may not be associated with headaches and dizziness reported by patients treated with the immediate-release formulation of sodium nitrite for diabetic peripheral neuropathy.

EEG Features as Markers of Neuropathic Pain in Spinal Cord Injury

EEG Features as Markers of Neuropathic Pain in Spinal Cord Injury

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Patients with subacute spinal cord injury may present electroencephalographic features that predate the onset of neuropathic pain and may serve both as markers and predictors of neuropathic pain.

Pediatric Chemotherapy May Be Associated With Long-Term Peripheral Neuropathy

Pediatric Chemotherapy May Be Associated With Long-Term Peripheral Neuropathy

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Childhood cancer survivors are at risk for long-term peripheral neuropathy, particularly when treated with cisplatin.

Point-of-Care Conduction Device May Accurately Screen for Polyneuropathy in At-Risk Populations

Point-of-Care Conduction Device May Accurately Screen for Polyneuropathy in At-Risk Populations

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A point-of-care conduction device may provide accurate measurements of nerve amplitude potential and conduction velocity for the diagnosis of polyneuropathy in older patients.

Capsaicin 8% Patch May Be Effective in Neuropathic Pain

Capsaicin 8% Patch May Be Effective in Neuropathic Pain

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The use of a topical capsaicin 8%may be effective in neuropathic pain associated with postherpetic neuralgia or resulting from trauma or surgery.

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

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Specific countries officially recommend some screening questionnaires for the early assessment of neuropathic pain, with France recommending the DN4 and Germany recommending PainDETECT.

Factors Associated With Neuropathic Pain in Ankylosing Spondylitis

Factors Associated With Neuropathic Pain in Ankylosing Spondylitis

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A number of factors that include age, the presence of enthesitis, and depressive symptoms may be associated with neuropathic pain in ankylosing spondylitis.

Catastrophizing and Function in Chronic Spinal Pain

Catastrophizing and Function in Chronic Spinal Pain

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Pain catastrophizing may be associated with reduced psychological — and to a lesser extent physical —function in patients with neuropathic pain and spinal pain.

Severe MS Associated With Increased Neuropathic Pain Risk

Severe MS Associated With Increased Neuropathic Pain Risk

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Neuropathic pain is associated with a more severe multiple sclerosis disease phenotype.

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

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The effectiveness of cannabis-based products for chronic neuropathic pain is not supported by high-quality evidence.

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

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ZTlido is comprised of a non-aqueous adhesive material containing 1.8% lidocaine.

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

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Cotargeting of peripheral μ-opioid and cannabinoid receptors was found to have a synergistic effect in reducing mechanical allodynia in a mouse model of neuropathic pain.

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

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Although peripheral neuropathy is one of the most common neurologic problems seen in the primary care setting, recognizing and evaluating peripheral neuropathy in a patient can be challenging due to its diverse presentations.

Bedside Quantitative Sensory Testing May Reliably Assess Sensory Profiles in Neuropathic Pain

Bedside Quantitative Sensory Testing May Reliably Assess Sensory Profiles in Neuropathic Pain

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A bedside quantitative sensory testing using inexpensive handheld devices indicates that this test may reliably be used to assess sensory profiles in patients with neuropathic pain.

Safety, Efficacy of Lidocaine Infusion for Prolonged Neuropathic Pain

Safety, Efficacy of Lidocaine Infusion for Prolonged Neuropathic Pain

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Investigators sought to determine whether repeated intravenous low-dose lidocaine could provide prolonged pain relief in patients with refractory neuropathic pain.

Gluten-Free Diet May Relieve Peripheral Neuropathic Pain

Gluten-Free Diet May Relieve Peripheral Neuropathic Pain

For patients with gluten neuropathy, following a strict gluten-free diet is associated with significantly reduced odds of peripheral neuropathic pain.

Exploring the Connections Between Neuropathic Pain and Comorbid Mood Disorders

Exploring the Connections Between Neuropathic Pain and Comorbid Mood Disorders

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Substantial evidence suggests a close connection between neuropathic pain and mood disorders.

Weighted Score May Help in Diagnosing CRPS

Weighted Score May Help in Diagnosing CRPS

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Researchers have developed a weighted score that may be useful in the differential diagnosis of complex regional pain syndrome.

Optimal Approaches to the Management of Burn Pain: Expert Insight

Optimal Approaches to the Management of Burn Pain: Expert Insight

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Depending on the extent of the injury, pain due to burns can range from mild to severe to excruciating.

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