Neuropathic Pain

Featured Article

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Although peripheral neuropathy is one of the most common neurologic problems seen in the primary care setting, recognizing and evaluating peripheral neuropathy in a patient can be challenging due to its diverse presentations.

Latest

Severe MS Associated With Increased Neuropathic Pain Risk

Severe MS Associated With Increased Neuropathic Pain Risk

Neuropathic pain is associated with a more severe multiple sclerosis disease phenotype.

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

The effectiveness of cannabis-based products for chronic neuropathic pain is not supported by high-quality evidence.

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

ZTlido is comprised of a non-aqueous adhesive material containing 1.8% lidocaine.

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Cotargeting of peripheral μ-opioid and cannabinoid receptors was found to have a synergistic effect in reducing mechanical allodynia in a mouse model of neuropathic pain.

Positive Affect, Resilience, and Pain in MS With Chronic Pain

Positive Affect, Resilience, and Pain in MS With Chronic Pain

Resilience may mediate the relationships between positive affect and pain interference and depression in patients with multiple sclerosis.

Bedside Quantitative Sensory Testing May Reliably Assess Sensory Profiles in Neuropathic Pain

Bedside Quantitative Sensory Testing May Reliably Assess Sensory Profiles in Neuropathic Pain

A bedside quantitative sensory testing using inexpensive handheld devices indicates that this test may reliably be used to assess sensory profiles in patients with neuropathic pain.

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Although peripheral neuropathy is one of the most common neurologic problems seen in the primary care setting, recognizing and evaluating peripheral neuropathy in a patient can be challenging due to its diverse presentations.

Safety, Efficacy of Lidocaine Infusion for Prolonged Neuropathic Pain

Safety, Efficacy of Lidocaine Infusion for Prolonged Neuropathic Pain

Investigators sought to determine whether repeated intravenous low-dose lidocaine could provide prolonged pain relief in patients with refractory neuropathic pain.

Gluten-Free Diet May Relieve Peripheral Neuropathic Pain

Gluten-Free Diet May Relieve Peripheral Neuropathic Pain

For patients with gluten neuropathy, following a strict gluten-free diet is associated with significantly reduced odds of peripheral neuropathic pain.

Exploring the Connections Between Neuropathic Pain and Comorbid Mood Disorders

Exploring the Connections Between Neuropathic Pain and Comorbid Mood Disorders

Substantial evidence suggests a close connection between neuropathic pain and mood disorders.

Weighted Score May Help in Diagnosing CRPS

Weighted Score May Help in Diagnosing CRPS

Researchers have developed a weighted score that may be useful in the differential diagnosis of complex regional pain syndrome.

Comparing the Efficacy of Postherpetic Neuralgia Treatments for Pain Relief

Comparing the Efficacy of Postherpetic Neuralgia Treatments for Pain Relief

Analgesics may be more effective in alleviating pain associated with postherpetic neuralgia compared with topical therapies, antivirals, antidepressants, and antiepileptics.

Ketamine Infusion May Be Effective for the Short-Term Relief of CRPS-Associated Pain

Ketamine Infusion May Be Effective for the Short-Term Relief of CRPS-Associated Pain

Ketamine infusion may provide short-term pain relief for patients with complex regional pain syndrome.

Optimal Approaches to the Management of Burn Pain: Expert Insight

Optimal Approaches to the Management of Burn Pain: Expert Insight

Depending on the extent of the injury, pain due to burns can range from mild to severe to excruciating.

Vitamin E May Not Improve Diabetic Peripheral Neuropathy-Associated Symptoms

Vitamin E May Not Improve Diabetic Peripheral Neuropathy-Associated Symptoms

Oral vitamin E supplementation consisting of 400 mg/day mixed tocotrienols for 1 year may not result in improved neuropathic pain symptoms in patients with diabetic peripheral neuropathy.

Reviewing the Effectiveness of Lidocaine for the Management of Chronic Pain

Reviewing the Effectiveness of Lidocaine for the Management of Chronic Pain

Systemic lidocaine administered via IV or patch has consistently shown effectiveness for the treatment and prevention of chronic pain.

Burden Associated With Pharmacotherapy Switching in Trigeminal Neuralgia

Burden Associated With Pharmacotherapy Switching in Trigeminal Neuralgia

An examination of treatment patterns among patients with trigeminal neuralgia suggests that this orofacial disorder appears to be significantly burdensome.

Higher Reoperation Rates After Microvascular Decompression in Patients With Diabetes, Obesity

Higher Reoperation Rates After Microvascular Decompression in Patients With Diabetes, Obesity

Microvascular decompression for trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia was found to be a largely safe procedure.

Transforaminal Epidural Steroid Injections Effective for Pain Relief in Lumbar Foraminal Spinal Stenosis

Transforaminal Epidural Steroid Injections Effective for Pain Relief in Lumbar Foraminal Spinal Stenosis

Transforaminal epidural steroid injections may be more effective in relieving pain in patients with mild to moderate vs severe lower extremity radicular pain associated with lumbar foraminal spinal stenosis.

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

Patients with end-stage knee or hip osteoarthritis were found to often experience possible neuropathic pain - particularly pain at rest vs on activity, and in men.

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

Use of the 2006 vs 2007 criteria for the diagnosis of complex regional pain syndrome may lead to the misdiagnosis of patients experiencing unexplained excessive pain after total knee arthroplasty.

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

Opioids may be "life-transforming" for patients with refractory restless legs syndrome when taken in relatively low total daily doses, according to new guidelines.

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

Evidence for the effectiveness of oxcarbazepine in painful diabetic neuropathy and other forms of neuropathic pain is limited.

Migraine and Multiple Sclerosis: What Is the Link?

Migraine and Multiple Sclerosis: What Is the Link?

Increasing evidence suggests a relationship between migraine and multiple sclerosis that is beyond comorbidity and may help clarify the pathophysiology of both disorders.

Online Cognitive Behavioral Therapy May Provide Pain Relief in Chemotherapy-Induced Peripheral Neuropathy

Online Cognitive Behavioral Therapy May Provide Pain Relief in Chemotherapy-Induced Peripheral Neuropathy

Self-guided online cognitive behavioral pain management may result in improved "worst" pain but not "average" pain compared with usual care for the treatment of painful chemotherapy-induced peripheral neuropathy.

Neuromodulation for Refractory Trigeminal Neuralgia: Expert Feedback

Neuromodulation for Refractory Trigeminal Neuralgia: Expert Feedback

Neuromodulation techniques have been explored as alternative treatment options in patients with trigeminal neuralgia who do not achieve adequate pain relief with pharmacologic therapies and surgical interventions.

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Treatment with the capsaicin 8% patch Qutenza may be more effective than pregabalin for reducing the intensity and area of dynamic mechanical allodynia and for complete resolution of the disorder.

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic pain experienced by patients with pachyonychia congenita may be caused by damage to the peripheral nerve fibers, with the hyperalgesia and allodynia observed in affected regions likely to be manifestations of peripheral sensitization.

Chemonucleolysis With Radiopaque Gelified Ethanol May Be Effective Analgesic for Chronic Radicular Pain

Chemonucleolysis With Radiopaque Gelified Ethanol May Be Effective Analgesic for Chronic Radicular Pain

The use of percutaneous chemonucleolysis with radiopaque gelified ethanol may be safe and effective for patients with treatment-resistant chronic radicular leg pain.