Pregabalin Also Effective for Established Neuropathic Pain

HealthDay News — Pregabalin significantly improves neuropathic pain, irrespective of the time since pain onset, according to a study published online on September 2, 2016 in Pain Practice.1

Concepción Pérez, PhD, from the Hospital de la Princesa in Madrid, and colleagues conducted a pooled analysis of 19 randomized placebo-controlled trials of pregabalin for peripheral neuropathic pain conditions (including diabetic peripheral neuropathy, postherpetic neuralgia, and post-traumatic/postsurgical pain). Patients were divided into 5 categories according to time since onset of pain. For each category, the mean change in pain score at end point was assessed versus placebo. Data were included for 5,783 patients (3,619 pregabalin-treated and 2,164 placebo-treated).

The researchers found that across pain duration categories, the mean baseline pain scores were similar. In all patients together, pregabalin significantly improved pain score at end point vs placebo (treatment difference, −0.59); similar results were seen in each pain duration category. Significantly more Patient Global Impression of Change responders were seen with pregabalin vs placebo for all patients (45 vs 30.9%) and for each category separately. No consistent, significant differences in treatment response were seen between the different categories of pain duration.

“Pregabalin significantly improves pain, irrespective of the length of time since onset of neuropathic pain,” the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Pfizer, which manufactures pregabalin and funded the study.

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  1. Pérez C, Latymer M, Almas M, et al. Does Duration of Neuropathic Pain Impact the Effectiveness of Pregabalin? Pain Pract. 2016. DOI: 10.1111/papr.12469.