Neuropathic Pain News Archive

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

Reviewing the Efficacy, Safety, and Tolerability of Cannabis-Based Medicines for Chronic Neuropathic Pain

The effectiveness of cannabis-based products for chronic neuropathic pain is not supported by high-quality evidence.

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

ZTlido Approved to Treat Pain Associated With Postherpetic Neuralgia

ZTlido is comprised of a non-aqueous adhesive material containing 1.8% lidocaine.

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Peripherally Acting Opioid and Cannabinoid May Be Effective for Neuropathic Pain

Cotargeting of peripheral μ-opioid and cannabinoid receptors was found to have a synergistic effect in reducing mechanical allodynia in a mouse model of neuropathic pain.

Positive Affect, Resilience, and Pain in MS With Chronic Pain

Positive Affect, Resilience, and Pain in MS With Chronic Pain

Resilience may mediate the relationships between positive affect and pain interference and depression in patients with multiple sclerosis.

Bedside Quantitative Sensory Testing May Reliably Assess Sensory Profiles in Neuropathic Pain

Bedside Quantitative Sensory Testing May Reliably Assess Sensory Profiles in Neuropathic Pain

A bedside quantitative sensory testing using inexpensive handheld devices indicates that this test may reliably be used to assess sensory profiles in patients with neuropathic pain.

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Peripheral Neuropathy Management in the Primary Care Setting: A Guide

Although peripheral neuropathy is one of the most common neurologic problems seen in the primary care setting, recognizing and evaluating peripheral neuropathy in a patient can be challenging due to its diverse presentations.

Safety, Efficacy of Lidocaine Infusion for Prolonged Neuropathic Pain

Safety, Efficacy of Lidocaine Infusion for Prolonged Neuropathic Pain

Investigators sought to determine whether repeated intravenous low-dose lidocaine could provide prolonged pain relief in patients with refractory neuropathic pain.

Gluten-Free Diet May Relieve Peripheral Neuropathic Pain

Gluten-Free Diet May Relieve Peripheral Neuropathic Pain

For patients with gluten neuropathy, following a strict gluten-free diet is associated with significantly reduced odds of peripheral neuropathic pain.

Exploring the Connections Between Neuropathic Pain and Comorbid Mood Disorders

Exploring the Connections Between Neuropathic Pain and Comorbid Mood Disorders

Substantial evidence suggests a close connection between neuropathic pain and mood disorders.

Weighted Score May Help in Diagnosing CRPS

Weighted Score May Help in Diagnosing CRPS

Researchers have developed a weighted score that may be useful in the differential diagnosis of complex regional pain syndrome.

Comparing the Efficacy of Postherpetic Neuralgia Treatments for Pain Relief

Comparing the Efficacy of Postherpetic Neuralgia Treatments for Pain Relief

Analgesics may be more effective in alleviating pain associated with postherpetic neuralgia compared with topical therapies, antivirals, antidepressants, and antiepileptics.

Ketamine Infusion May Be Effective for the Short-Term Relief of CRPS-Associated Pain

Ketamine Infusion May Be Effective for the Short-Term Relief of CRPS-Associated Pain

Ketamine infusion may provide short-term pain relief for patients with complex regional pain syndrome.

Optimal Approaches to the Management of Burn Pain: Expert Insight

Optimal Approaches to the Management of Burn Pain: Expert Insight

Depending on the extent of the injury, pain due to burns can range from mild to severe to excruciating.

Vitamin E May Not Improve Diabetic Peripheral Neuropathy-Associated Symptoms

Vitamin E May Not Improve Diabetic Peripheral Neuropathy-Associated Symptoms

Oral vitamin E supplementation consisting of 400 mg/day mixed tocotrienols for 1 year may not result in improved neuropathic pain symptoms in patients with diabetic peripheral neuropathy.

Reviewing the Effectiveness of Lidocaine for the Management of Chronic Pain

Reviewing the Effectiveness of Lidocaine for the Management of Chronic Pain

Systemic lidocaine administered via IV or patch has consistently shown effectiveness for the treatment and prevention of chronic pain.

Burden Associated With Pharmacotherapy Switching in Trigeminal Neuralgia

Burden Associated With Pharmacotherapy Switching in Trigeminal Neuralgia

An examination of treatment patterns among patients with trigeminal neuralgia suggests that this orofacial disorder appears to be significantly burdensome.

Higher Reoperation Rates After Microvascular Decompression in Patients With Diabetes, Obesity

Higher Reoperation Rates After Microvascular Decompression in Patients With Diabetes, Obesity

Microvascular decompression for trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia was found to be a largely safe procedure.

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

Neuropathic Pain Common in End-Stage Knee, Hip Osteoarthritis

Patients with end-stage knee or hip osteoarthritis were found to often experience possible neuropathic pain - particularly pain at rest vs on activity, and in men.

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

Updated Criteria for CRPS Diagnosis May Reveal Presence of Neuropathic Pain After TKA

Use of the 2006 vs 2007 criteria for the diagnosis of complex regional pain syndrome may lead to the misdiagnosis of patients experiencing unexplained excessive pain after total knee arthroplasty.

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

New Guidelines for Opioid Use in Refractory Restless Leg Syndrome

Opioids may be "life-transforming" for patients with refractory restless legs syndrome when taken in relatively low total daily doses, according to new guidelines.

Improved Peripheral, Central Pain Sensitization After Bariatric Surgery

Improved Peripheral, Central Pain Sensitization After Bariatric Surgery

Patients who are obese and experience knee pain were found to have improved pressure pain threshold at the patella and the wrist after weight loss associated with bariatric surgery vs medical management.

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

Limited Evidence for the Effectiveness of Oxcarbazepine in Neuropathic Pain

Evidence for the effectiveness of oxcarbazepine in painful diabetic neuropathy and other forms of neuropathic pain is limited.

Migraine and Multiple Sclerosis: What Is the Link?

Migraine and Multiple Sclerosis: What Is the Link?

Increasing evidence suggests a relationship between migraine and multiple sclerosis that is beyond comorbidity and may help clarify the pathophysiology of both disorders.

Online Cognitive Behavioral Therapy May Provide Pain Relief in Chemotherapy-Induced Peripheral Neuropathy

Online Cognitive Behavioral Therapy May Provide Pain Relief in Chemotherapy-Induced Peripheral Neuropathy

Self-guided online cognitive behavioral pain management may result in improved "worst" pain but not "average" pain compared with usual care for the treatment of painful chemotherapy-induced peripheral neuropathy.

Neuromodulation for Refractory Trigeminal Neuralgia: Expert Feedback

Neuromodulation for Refractory Trigeminal Neuralgia: Expert Feedback

Neuromodulation techniques have been explored as alternative treatment options in patients with trigeminal neuralgia who do not achieve adequate pain relief with pharmacologic therapies and surgical interventions.

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Capsaicin Patch Superior to Pregabalin for Alleviating, Resolving Dynamic Mechanical Allodynia

Treatment with the capsaicin 8% patch Qutenza may be more effective than pregabalin for reducing the intensity and area of dynamic mechanical allodynia and for complete resolution of the disorder.

Gabapentinoid Use Increased in the United States Over Last Decade

Gabapentinoid Use Increased in the United States Over Last Decade

From 2002 to 2015, the percentage of individuals in the United States who used gabapentin and/or pregabalin increased in 1.2% to 3.9%.

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic Pain in Pachyonychia Congenita May Have Neuropathic Origin

Chronic pain experienced by patients with pachyonychia congenita may be caused by damage to the peripheral nerve fibers, with the hyperalgesia and allodynia observed in affected regions likely to be manifestations of peripheral sensitization.

Peripheral Nerve Stimulation May Provide Long-Term Pain Relief for Leprosy-Related Mononeuropathy

Peripheral Nerve Stimulation May Provide Long-Term Pain Relief for Leprosy-Related Mononeuropathy

Peripheral nerve stimulation may provide long-term pain relief in patients with painful mononeuropathy secondary to leprosy.

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

After 5 years, 55% of patients had experienced treatment success and 80% of patients with a permanent implant still used their SCS device.

Pregabalin Monotherapy Superior to Opioids With or Without Pregabalin in Patients With Fibromyalgia

Pregabalin Monotherapy Superior to Opioids With or Without Pregabalin in Patients With Fibromyalgia

The use of pregabalin alone vs pregabalin plus opioids or opioids alone may result in more favorable outcomes in terms of pain interference and pain severity in patients with fibromyalgia.

Acupuncture May Alleviate Pain in Idiopathic Trigeminal Neuralgia

Acupuncture May Alleviate Pain in Idiopathic Trigeminal Neuralgia

Acupuncture may reduce pain intensity and mechanical thresholds in patients with idiopathic trigeminal neuralgia.

Pain in Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach

Pain in Elite Athletes: IOC Recommendations on Contributing Factors and Treatment Approach

Pain management in athletes requires a clear understanding of the different types of pain and various factors that can contribute to pain in this population.

Virtual Reality Effective on Spinal Cord Injury-Related Chronic Neuropathic Pain

Virtual Reality Effective on Spinal Cord Injury-Related Chronic Neuropathic Pain

The use of virtual reality (VR) and multisensory stimulation in patients with spinal cord injury promotes mild relief from chronic neuropathic pain and represents a potentially helpful addition to SCI neurorehabilitation management.

Hand Osteoarthritis Pain Alleviated With Pregabalin

Hand Osteoarthritis Pain Alleviated With Pregabalin

Pregabalin, but not duloxetine, was shown to improve pain and function scores in patients with hand osteoarthritis.

Hypoalgesia, Hyperalgesia Linked to Multiple Sclerosis Lesion Location

Hypoalgesia, Hyperalgesia Linked to Multiple Sclerosis Lesion Location

In patients with multiple sclerosis, lesions in the right dorsolateral prefrontal cortex and posterior periventricular area may be associated with hypo and hyperalgesia.

Dronabinol Safe and Effective for Neuropathic Pain Associated With Multiple Sclerosis

Dronabinol Safe and Effective for Neuropathic Pain Associated With Multiple Sclerosis

Dronabinol provides a safe and effective treatment option for patients with symptoms of neuropathic pain associated with multiple sclerosis.

Peripheral Neuropathy in Patients With HIV: Association With Additional Pain Disorders

Peripheral Neuropathy in Patients With HIV: Association With Additional Pain Disorders

Patients with a diagnosis of HIV and peripheral neuropathy often have ≥1 additional pain disorders.

Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

Peripheral Nerve Surgery for Burn Survivors: Improving Outcomes Through Clinician Self-Analysis

As survival rates for patients with burns have improved, the need for effective treatments for chronic pain in this population has become more pressing.

Chemotherapy-Induced Peripheral Neuropathy: Mechanism Identified

Chemotherapy-Induced Peripheral Neuropathy: Mechanism Identified

The researchers found that paclitaxel triggers CIPN by altering IP3 receptor phosphorylation and intracellular calcium flux and activating calcium-dependent calpain proteases.

Cryotherapy May Prevent Symptoms of Chemotherapy-Induced Peripheral Neuropathy

Cryotherapy May Prevent Symptoms of Chemotherapy-Induced Peripheral Neuropathy

A recent study evaluated the efficacy of cryotherapy for chemo-induced peripheral neuropathy; study participants wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion.

Trigeminal Neuralgia Linked to Multiple Sclerosis: Comparing Surgical Interventions

Trigeminal Neuralgia Linked to Multiple Sclerosis: Comparing Surgical Interventions

Radiofrequency rhizotomy and the more expensive stereotactic radio surgery provide immediate pain relief from trigeminal neuralgia associated with multiple sclerosis.

Acupuncture for Chronic Pain Relief in Military Populations

Acupuncture for Chronic Pain Relief in Military Populations

Electrical stimulation and a higher baseline pain score were shown to be associated with a higher chance of improved pain relief with acupuncture.

Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

Neuropathy Associated With Adjuvant Chemotherapy: Characteristics

Chronic pain following adjuvant chemotherapy with docetaxel or oxaliplatin may be solely account for by pure sensory neuropathy.

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

Neuroinflammation in Neuropathic Pain Indicated by Elevated Levels of Proinflammatory Chemokines in CSF

Patients with neuropathic pain have elevated levels of a set of pro-inflammatory chemokines compared with healthy individuals, suggesting ongoing neuroinflammation.

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

FDA Approves New Treatment for Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

The FDA has approved Lyrica CR, a once-daily treatment for the management of neuropathic pain associated with diabetic peripheral neuropathy and the management of postherpetic neuralgia.

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

Opioid, Gabapentin Combo Rx May Increase Mortality Risk

Both gabapentin and opioids are commonly prescribed for the treatment of pain, making the likelihood of these two agents being prescribed together high.

Restless Leg Syndrome Responsiveness to Rotigotine, Gabapentin Enacarbil, and Pregabalin

Restless Leg Syndrome Responsiveness to Rotigotine, Gabapentin Enacarbil, and Pregabalin

The dopaminergic medication rotigotine and the α-2-δ ligands gabapentin enacarbil and pregabalin provide similar treatment effects for patients with restless leg syndrome.

Chronic Inflammatory Demyelinating Polyneuropathy: Privigen Gains FDA Approval

Chronic Inflammatory Demyelinating Polyneuropathy: Privigen Gains FDA Approval

Privigen is stabilized with proline, which has been shown to reduce IgG aggregation and dimer formation.

Capsaicin 8% Patch Safe for Peripheral Neuropathic Pain

Capsaicin 8% Patch Safe for Peripheral Neuropathic Pain

The use of capsaicin 8% patch repeat treatment is well tolerated and may provide effective long-term benefit in patients with peripheral neuropathic pain.

Gabapentinoids: Evaluating the Benefits for Chronic Low Back Pain

Gabapentinoids: Evaluating the Benefits for Chronic Low Back Pain

Gabapentinoid use presents significant risk for adverse events and provides few benefits for patients with chronic low back pain.

Chemo-Induced Peripheral Neuropathy Risk Reduced With Multivitamin

Chemo-Induced Peripheral Neuropathy Risk Reduced With Multivitamin

Multivitamin use before diagnosis of breast cancer is associated with reduced risk of symptoms of chemotherapy-induced peripheral neuropathy.

Cannabis for Neuropathic Pain: What Evidence Is There?

Cannabis for Neuropathic Pain: What Evidence Is There?

There is currently little conclusive evidence to suggest a benefit of cannabis use for the management of neuropathic pain.

Gabapentin, Pregabalin Effective for Burn-Related Pruritus, Neuropathic Pain

Gabapentin, Pregabalin Effective for Burn-Related Pruritus, Neuropathic Pain

The use of gabapentin, pregabalin, or both is effective for reducing pruritus and neuropathic pain in burn survivors.

Pregabalin vs Gabapentin for Neuropathic Pain to Achieve Therapeutic Dose

Pregabalin vs Gabapentin for Neuropathic Pain to Achieve Therapeutic Dose

Patients with neuropathic pain are more likely to achieve effective therapeutic dose when treated with pregabalin compared with gabapentin.

Vitamin D Deficiency Associated With Neuropathic Pain in Rheumatoid Arthritis

Vitamin D Deficiency Associated With Neuropathic Pain in Rheumatoid Arthritis

In patients with rheumatoid arthritis, vitamin D deficiency was shown to be associated with increased neuropathic pain.

Nighttime Opioid Combination to Treat Fibromyalgia With PTSD

Nighttime Opioid Combination to Treat Fibromyalgia With PTSD

In patients with concomitant fibromyalgia and PTSD, opioid therapy was shown to improve quality of life and help patients return to a greater sense of "normalcy."

Diabetic Peripheral Neuropathic Pain: Evaluating Treatment Options

Diabetic Peripheral Neuropathic Pain: Evaluating Treatment Options

Dr Cuevas-Trisan covered the evaluation and management of diabetic peripheral neuropathic pain during his presentation at PAINWeek 2017.

Preemptive Analgesia to Prevent Chronic Postsurgical Pain

Preemptive Analgesia to Prevent Chronic Postsurgical Pain

Preemptive analgesia seeks to prevent central sensitization and ensuing chronic pain, a concept that has shown promising results in preliminary studies.

Is Nerve Decompression Effective for Restless Leg Syndrome?

Is Nerve Decompression Effective for Restless Leg Syndrome?

Nerve decompression used to treat peripheral neuropathy may improve symptoms of restless leg syndrome.

Gabapentinoids: Are They Overprescribed?

Gabapentinoids: Are They Overprescribed?

Clinicians may be overprescribing gabapentinoids, in part as a response to the opioid epidemic, and prescribing them for almost any type of pain.

Intravenous Lidocaine Safe, Effective for Chronic Pain

Intravenous Lidocaine Safe, Effective for Chronic Pain

Lidocaine infusions were shown to provide long-lasting and adequate analgesia in 41% of patients with chronic pain.

Neuropathic Pain: Assessing Safety, Efficacy of Higher Pregabalin Doses

Neuropathic Pain: Assessing Safety, Efficacy of Higher Pregabalin Doses

Patients with neuropathic pain who do not respond to a low dose of pregabalin can benefit from a higher dose.

Long-Term Opioid Therapy Linked to Adverse Effects in Polyneuropathy

Long-Term Opioid Therapy Linked to Adverse Effects in Polyneuropathy

Long-term treatment with opioids is associated with more adverse outcomes in patients with polyneuropathy, including depression, overdose, and opioid dependence.

Morphine Lacks Efficacy for RA, Chronic Fatigue Syndrome and Fibromyalgia

Morphine Lacks Efficacy for RA, Chronic Fatigue Syndrome and Fibromyalgia

For patients with chronic fatigue syndrome/fibromyalgia or rheumatoid arthritis, morphine has anti-hyperalgesic effects comparable with placebo.

Updated Diagnostic Criteria for Neuropathic Pain in SCI, Stroke, MS

Updated Diagnostic Criteria for Neuropathic Pain in SCI, Stroke, MS

The diagnostic criteria formulated by the ACTTION-APS Pain Taxonomy working group focus on neuropathic pain from SCI, stroke, and MS.

Orexin Receptor Antagonist Ineffective on Painful Diabetic Neuropathy

Orexin Receptor Antagonist Ineffective on Painful Diabetic Neuropathy

Filorexant is not effective in relieving painful diabetic neuropathy-related pain.

Neuropathic Pain in Low Back-Related Leg Pain: the State of Evidence

Neuropathic Pain in Low Back-Related Leg Pain: the State of Evidence

A systematic review points to a dearth of evidence regarding the neuropathic etiology of low back-related leg pain.

Current State of Evidence on Ketamine: Uses, Effects, Research

Current State of Evidence on Ketamine: Uses, Effects, Research

Ketamine was found to alleviate several pain modalities, and a number of clinical trials investigating its efficacy are ongoing.

Gabapentin Assessed in Chronic Neuropathic Pain

Gabapentin Assessed in Chronic Neuropathic Pain

Gabapentin, at doses of 1800 mg to 3600 mg can provide "good levels of pain relief" to some individuals suffering from postherpetic neuralgia and peripheral diabetic neuropathy.

Allodynia and Pericranial Tenderness Highly Prevalent in Pediatric Patients With Migraine

Allodynia and Pericranial Tenderness Highly Prevalent in Pediatric Patients With Migraine

Symptoms associated with central sensitization are common in children and adolescents with migraine.

Response to Pregabalin for Fibromyalgia-Related Pain in Patients Taking Antidepressants

Response to Pregabalin for Fibromyalgia-Related Pain in Patients Taking Antidepressants

Researchers identified characteristics associated with pain improvement in patients with fibromyalgia who take antidepressant medications.

Cannabinoids May Provide Limited Relief From Neuropathic Pain

Cannabinoids May Provide Limited Relief From Neuropathic Pain

Selective cannabinoids may provide limited relief from chronic neuropathic pain and improvements in quality of life and sleep.

Association Between Osteoporosis and Multiple Sclerosis

Association Between Osteoporosis and Multiple Sclerosis

Patients with multiple sclerosis (MS) have lower bone mineral density and greater rates of osteoporosis than healthy controls.

Long-Term Opioids Associated With Worse Functional Status, Adverse Events in Polyneuropathy

Long-Term Opioids Associated With Worse Functional Status, Adverse Events in Polyneuropathy

Polyneuropathy may increase the likelihood of patients receiving long-term opioid therapy.

Genetic Variant Tied to Systemic Lupus Identified

Genetic Variant Tied to Systemic Lupus Identified

A genetic variant that is associated with both multiple sclerosis and systemic lupus erythematosus has been identified.

Greater Trauma Associated With Amplification of Pain, Spinal Nociception

Greater Trauma Associated With Amplification of Pain, Spinal Nociception

Trauma exposure plays a significant role in both pain response and development of chronic pain.

Trigeminal Neuralgia: Assessing Treatment Patterns to Improve Outcomes

Trigeminal Neuralgia: Assessing Treatment Patterns to Improve Outcomes

In a 3-year period, 45% of patients with trigeminal neuralgia received at least 3 unique treatments.

Cibinetide for the Treatment of Sarcoidosis

Cibinetide for the Treatment of Sarcoidosis

Cibinetide, an innate repair receptor agonist, was shown to exert disease-modifying effects by reversing sarcoidosis-related nerve loss in the cornea and skin.

Bortezomib-Induced Neuropathy From First to Second Treatment for Multiple Myeloma

Bortezomib-Induced Neuropathy From First to Second Treatment for Multiple Myeloma

Bortezomib-induced peripheral neuropathy does not worsen between initial treatment and retreatment in patients with multiple myeloma.

Chronic Tension-Type Headaches: Pain Extent Associated With Emotional, Physical Burden

Chronic Tension-Type Headaches: Pain Extent Associated With Emotional, Physical Burden

Greater pain extent of chronic tension-type headaches correlates with older age and with greater emotional and physical burdens in patients.

Pregabalin Not Effective for Sciatica Treatment

Pregabalin Not Effective for Sciatica Treatment

A randomized trial found that pregabalin is not more effective than placebo in treating sciatica, and resulted in more adverse effects.

Capsaicin 8% Patch Effective on Nondiabetic Peripheral Neuropathic Pain

Capsaicin 8% Patch Effective on Nondiabetic Peripheral Neuropathic Pain

Results from the ASCEND study recently published in BioMed Central Neurology indicate that an 8% capsaicin patch is effective in relieving peripheral neuropathic pain resulting from a wide range of etiologies.

Antidepressant Serum Levels may be Lower in Cigarette Smokers

Antidepressant Serum Levels may be Lower in Cigarette Smokers

Serum concentration levels of several antidepressants were lower in cigarette smokers vs non-smokers.

Secondary Hyperalgesia Mediated by Nociceptive and Other Sensory Pathways

Secondary Hyperalgesia Mediated by Nociceptive and Other Sensory Pathways

The effects of central sensitization extend beyond nociceptive pathways to other sensory modalities.

Preclinical Pain as a Marker for Amyotrophic Lateral Sclerosis

Preclinical Pain as a Marker for Amyotrophic Lateral Sclerosis

Pain is far more common and widespread in ALS than previously suspected, and initial pain symptoms may predate the clinical onset of the disease's hallmark motor dysfunction by as much as 2 years.

Ketamine for Refractory Neuropathic Pain

Ketamine for Refractory Neuropathic Pain

A ketamine regimen is superior to methadone, or ketamine combined with methadone, in alleviating neuropathic pain and associated sensory changes.

Strategies to Prevent the Transition From Postoperative Acute Pain to Chronic Pain

Strategies to Prevent the Transition From Postoperative Acute Pain to Chronic Pain

A number of shortcomings are associated with systematic reviews and meta-analyses of postoperative care.

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

Is Opioid-Induced Hyperalgesia Lessened by Switching to Buprenorphine?

Changes in several measures of pain in patients suspected of opioid-induced hyperalgesia were observed after transitioning from opioids to buprenorphine.

Drugs Effective on Diabetic Peripheral Neuropathy-Related Pain

Drugs Effective on Diabetic Peripheral Neuropathy-Related Pain

Several classes of drugs reduce neuropathy-related pain better than placebo.

DRG Stimulation Superior to Spinal Cord Stimulation for Lower Extremity Pain

DRG Stimulation Superior to Spinal Cord Stimulation for Lower Extremity Pain

Dorsal root ganglion stimulation is more likely than spinal cord stimulation to provide pain relief in patients with neuropathic pain conditions affecting the lower extremities.

Pregabalin for Sciatica: Is It Effective?

Pregabalin for Sciatica: Is It Effective?

In patients with sciatica pain, treatment with pregabalin did not significantly reduce pain intensity compared with placebo.

Neuropathic Pain Complexity Requires Thoughtful Approach and Combination of Interventions

Neuropathic Pain Complexity Requires Thoughtful Approach and Combination of Interventions

The wide range of etiologies underlying neuropathic pain render it a particularly challenging condition to manage.

Central Neuropathic Pain Syndromes

Central Neuropathic Pain Syndromes

Differentiating central neuropathic pain from musculoskeletal or peripheral neuropathic pain can be challenging.

Diabetic Neuropathy: Updated Position Statement by the American Diabetes Association

Diabetic Neuropathy: Updated Position Statement by the American Diabetes Association

The American Diabetes Association released an updated position statement on the prevention, detection, and management of diabetic neuropathies.

Optic Neuritis RENEW Trial Results

Optic Neuritis RENEW Trial Results

The human monoclonal antibody opicinumab may potentially enhance spontaneous remyelination after acute optic neuritis.

Neurofeedback for Chemotherapy-induced Peripheral Neuropathy

Neurofeedback for Chemotherapy-induced Peripheral Neuropathy

Patients in the neurofeedback group reported significant declines in CIPN symptoms, compared with patients who did not get neurofeedback training.

Optimal Management of Post-mastectomy Pain Syndrome

Optimal Management of Post-mastectomy Pain Syndrome

Limited data suggest antidepressants, topical capsaicin, and fat grafting may reduce pain associated with post-mastectomy pain syndrome, but more and better studies are needed to determine optimal management for this debilitating condition.

Risks Associated With Neuropathic Pain Treatment

Risks Associated With Neuropathic Pain Treatment

Death and serious outcomes resulting from overdose or poisoning from drugs used to treat depression more than doubled during the last decade and a half, found a recent study, with amitriptyline topping the list.

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