Generic Name and Formulations:
Vinorelbine (as tartrate) 10mg/mL; soln for IV inj after dilution; preservative-free.
Pierre Fabre Pharmaceuticals, Inc.
Indications for NAVELBINE:
First-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), in combination with cisplatin. As a single agent, for the treatment of patients with metastatic NSCLC.
See full labeling. Give by IV inj over 6–10mins. Monotherapy: 30mg/m2 once weekly. Combination therapy: 25mg/m2 on Days 1, 8, 15, and 21 of a 28-day cycle with cisplatin (100mg/m2) given on Day 1 of each 28-day cycle; or 30mg/m2 once weekly with cisplatin (120mg/m2) given on Days 1 and 29, then every 6 weeks. Dose modifications for toxicities, hepatic impairment: see full labeling.
Risk of myelosuppression. Monitor for infection, and/or fever; obtain CBCs with differentials prior to each dose. Discontinue if neurotoxicity ≥grade 2. Pre-existing pulmonary dysfunction or neuropathy. Hepatic injury or impairment: assess hepatic function prior to and during treatment. Cardiovascular disease. Avoid extravasation. Embryo-fetal toxicity. Females of reproductive potential should use highly effective contraception during therapy. Pregnancy (Cat.D), nursing mothers: not recommended.
May be potentiated by CYP3A inhibitors. Increased risk of granulocytopenia with cisplatin.
Neutropenia, anemia, elevated liver enzymes, nausea, vomiting, asthenia, constipation, inj site reaction, peripheral neuropathy; hepatotoxicity, pulmonary toxicity, bowel obstruction, paralytic ileus.
Single-use vial (1mL, 5mL)—1
Clinical Pain Advisor Articles
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Reducing Mortality After Overdose: Is Treatment for Opioid Use Disorder Effective?
- A Physician's Guide to Incorporating Patient Spirituality in Practice
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- The Challenge of Compassion in Modern Healthcare Settings
- Republican Opposition to Obamacare: What's Done, What's to Come
- Lowering Default Pill Counts in EMRs May Effectively Reduce Postoperative Opioid Prescription Numbers
- Steps Taken to Increase Use of Electronic Tools in Medicine
- Daily and Retrospective Pain Measurements Comparable in Hip Osteoarthritis