Generic Name and Formulations:
Nesiritide 1.5mg/vial; pwd for IV inj after reconstitution and dilution; contains mannitol.
Indications for NATRECOR:
Acutely decompensated CHF with dyspnea at rest or with minimal activity.
2mcg/kg IV bolus once, then 0.01mcg/kg per minute by continuous IV infusion; limited experience with therapy >96 hours. Doses up to 0.03mcg/kg per minute have been used; see full labeling. Reduce dose or discontinue if symptomatic hypotension occurs.
Persistent systolic BP <100mmHg. Cardiogenic shock.
Not recommended in significant valvular stenosis, restrictive or obstructive cardiomyopathy, constrictive pericarditis, pericardial tamponade, other conditions where vasodilators are inappropriate, or when cardiac output is dependent on venous return, or in patients with low cardiac filling pressures. Impaired renal function (esp if severe heart failure); monitor serum creatinine during and after therapy until stabilized. Monitor BP closely. Pregnancy (Cat.C). Nursing mothers.
Vasodilator (human B-type natriuretic peptide).
Hypotension potentiated by ARBs and/or ACE inhibitors.
Hypotension, headache, nausea, back pain, dizziness; hypersensitivity.
Clinical Pain Advisor Articles
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Reducing Mortality After Overdose: Is Treatment for Opioid Use Disorder Effective?
- A Physician's Guide to Incorporating Patient Spirituality in Practice
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- The Challenge of Compassion in Modern Healthcare Settings
- Republican Opposition to Obamacare: What's Done, What's to Come
- Lowering Default Pill Counts in EMRs May Effectively Reduce Postoperative Opioid Prescription Numbers
- Steps Taken to Increase Use of Electronic Tools in Medicine
- Daily and Retrospective Pain Measurements Comparable in Hip Osteoarthritis