Poor sleep quality and greater fatigue may be associated with pain exacerbation in patients with symptomatic hip osteoarthritis, according to results published in The Journal of Rheumatology.

A total of 252 individuals with symptomatic hip osteoarthritis were enrolled and asked to complete online questionnaires at 10-day intervals for 90 days. Hip pain exacerbation was defined as an increase of 2 points in pain intensity assessed on a 0 to 10 numeric rating scale compared with baseline. The Pittsburgh Sleep Quality Index was used to assess subjective sleep quality and duration, and the Multidimensional Assessment of Fatigue was used to assess fatigue.

Of 252 participants, 130 (52%) were included in the final analysis. Poor sleep quality and greater fatigue were found to be associated with increased odds of pain exacerbations (odds ratio [OR], 1.72; 95% CI, 1.04-2.86; and OR, 1.92; 95% CI, 1.21-3.05, respectively) in a univariate association analysis. No associations were established between short sleep duration and pain exacerbation.

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After adjusting for physical activity and pain levels at night, poor sleep quality and greater fatigue were both still associated with pain exacerbations (OR, 2.71; 95% CI, 1.42-5.16; and OR, 2.55; 95% CI, 1.41-4.63, respectively). No association between sleep quality and fatigue was established (P =.21).

“Interventions to reduce [osteoarthritis] pain may be enhanced by giving more attention to sleep and fatigue in persons with hip [osteoarthritis],” noted the researchers.

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Fu K, Makovey J, Metcalf B, et al. Sleep quality and fatigue are associated with pain exacerbations of hip osteoarthritis: an internet-based case-crossover study. [published online April 1, 2019]. J Rheumatol. doi:10.3899/jrheum.181406