Patients with axial spondyloarthritis (axSpA) who have inflammatory back pain or neuropathic pain may have higher pain intensity, pain interference, and disease activity, and greater functional limitation compared with individuals with axSpA but without either comorbidity, according to a study published in Pain Medicine.
The study included 132 participants with axSpA recruited from a university-affiliated hospital in China in whom the presence of inflammatory back pain and neuropathic pain was assessed, as well as pain intensity and quality, pain interference, disease activity, and functional status. Univariate analyses and binary logistic regressions were used to identify factors related to inflammatory back pain and neuropathic pain.
A total of 50 and 22 participants (37.9% and 16.7%, respectively) were found to have inflammatory back pain and neuropathic pain. Patients with inflammatory back pain or neuropathic pain were found to have higher pain intensity, pain interference, disease activity, and functional limitation scores compared with participants without either condition (P <.05).
A correlation was established between inflammatory back pain and disease activity (odds ratio [OR], 1.813; 95% CI, 1.196-2.750) and between neuropathic pain and functional limitation (OR, 1.544; 95% CI, 1.098–2.171).
“These results suggest that evaluating for these conditions may help guide clinical treatment and outcome evaluation in patients [with axial spondyloarthritis],” the researchers wrote.
Ji Y, He Y, Nian X, et al. Inflammatory or neuropathic pain: characteristics and their relationships with disease activity and functional status in axial spondyloarthritis patients. [Published online July 17, 2018]. Pain Med. doi:10.1093/pm/pny138