Migraine

Endothelial Dysfunction Biomarkers Elevated During Migraine Attacks in Women

Endothelial Dysfunction Biomarkers Elevated During Migraine Attacks in Women

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Women may have greater carotid intima-media thickness and elevated levels of biomarkers of endothelial dysfunction during a migraine attack.

Generalized Mechanical Hyperalgesia in Chronic Migraine, Temporomandibular Disorder

Generalized Mechanical Hyperalgesia in Chronic Migraine, Temporomandibular Disorder

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Individuals with chronic migraine and temporomandibular disorder may have mechanical hyperalgesia in the trigeminal and extra-trigeminal regions.

OnabotulinumtoxinA Improves Outcomes in Chronic Migraine With or Without Allodynia

OnabotulinumtoxinA Improves Outcomes in Chronic Migraine With or Without Allodynia

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OnabotulinumtoxinA treatment was found to reduce the frequency and severity of monthly headache days and to improve quality of life and disability in patients with chronic migraine with or without allodynia.

OnabotulinumtoxinA Effective in Reducing Depression and Anxiety Symptoms in Chronic Migraines

OnabotulinumtoxinA Effective in Reducing Depression and Anxiety Symptoms in Chronic Migraines

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OnabotulinumtoxinA not only reduced headache frequency for patients with chronic migraines, but also showed potential for clinically reducing depression and anxiety symptoms.

Cortical Thinning in Specific Brain Regions May Be Associated With Migraine

Cortical Thinning in Specific Brain Regions May Be Associated With Migraine

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Establishing a biomarker, namely cortical thinning, for patients with migraine may help to classify phenotypes for the disease, such as aging.

New Research Further Explores Alcohol's Role as a Migraine Trigger

New Research Further Explores Alcohol's Role as a Migraine Trigger

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Alcohol was a reported migraine trigger in 35.6% of participants, and approximately 25% of patients reported abstaining from alcohol because of its trigger effects.

Migraine Symptoms Can Improve Despite Unchanged Pain Avoidance, Endurance

Migraine Symptoms Can Improve Despite Unchanged Pain Avoidance, Endurance

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Improvements in headache frequency and disability may be observed in individuals with migraine without changes in pain avoidance or endurance behavior.

Tosymra Approved for the Acute Treatment of Migraine

Tosymra Approved for the Acute Treatment of Migraine

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The Food and Drug Administration has approved Tosymra for the acute treatment of migraines with or without aura in adults.

Migraine and Alcohol: Encouraging a Healthy Balance of Indulgence and Vigilance

Migraine and Alcohol: Encouraging a Healthy Balance of Indulgence and Vigilance

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Based on the literature, investigators found no reason to tell patients with headache to abstain from alcohol.

Galcanezumab Safe, Effective for Reducing Monthly Migraine Headache Days

Galcanezumab Safe, Effective for Reducing Monthly Migraine Headache Days

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In patients with chronic migraine, monthly subcutaneous injections of galcanezumab at 120- and 240-mg doses were more effective than placebo for lowering the number of monthly migraine headache days.

Mobile Health Apps for Headache: An Ongoing Search for Clinical Relevancy

Mobile Health Apps for Headache: An Ongoing Search for Clinical Relevancy

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The main objection among clinical researchers is that commercially developed products often lack a scientific basis for their selection of features.

Meta-Analysis: Botulinum A Injections Superior to Placebo for Chronic Migraine

Meta-Analysis: Botulinum A Injections Superior to Placebo for Chronic Migraine

For chronic migraine, botulinum type A injections are superior to placebo after three months of therapy.

Galcanezumab Demonstrates Efficacy and Safety in Treating Migraine

Galcanezumab Demonstrates Efficacy and Safety in Treating Migraine

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Most participants reported positive feedback in terms of satisfaction, lower side effects, and preference for galcanezumab compared with previous treatments.

Migraine History Common in Patients With Spontaneous Coronary Artery Dissection

Migraine History Common in Patients With Spontaneous Coronary Artery Dissection

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Many patients with spontaneous coronary artery dissection, particularly those with depression and with spontaneous coronary artery dissection-related chest pain, also have a history of migraine.

Questionnaire May Reliably Identify Fibromyalgia in Patients With Chronic Daily Headache

Questionnaire May Reliably Identify Fibromyalgia in Patients With Chronic Daily Headache

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The Fibromyalgia Rapid Screening Tool may be reliable for detecting fibromyalgia in patients with chronic daily headache.

Behavioral Therapies May Treat Headache and Post-Concussive Symptoms

Behavioral Therapies May Treat Headache and Post-Concussive Symptoms

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An education-based therapy may enable a healthier outcome, and telephonic modalities may improve symptoms of the brain injury.

Peripheral Nerve Decompression Surgery May Be Effective in Migraine

Peripheral Nerve Decompression Surgery May Be Effective in Migraine

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Peripheral nerve decompression surgery may be effective in reducing migraine headache frequency and intensity.

Migraine History Linked to Increase in All-Cause Dementia Risk

Migraine History Linked to Increase in All-Cause Dementia Risk

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Investigators confirmed an association between headache disorders and increased risk for dementia in this pooled meta-analysis; however, the number of studies was small and the population characteristics and study designs were quite heterogenous.

Vagus Nerve Stimulation Superior to Sham Device for Acute Migraine Treatment

Vagus Nerve Stimulation Superior to Sham Device for Acute Migraine Treatment

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Researchers sought to determine whether noninvasive vagus nerve stimulation significantly reduces the amount of pain or even takes pain away entirely in patients with episodic migraine.

IV Fluid Confers No Significant Treatment Effect on Migraine Pain

IV Fluid Confers No Significant Treatment Effect on Migraine Pain

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Investigators analyzed the effectiveness of IV fluid therapy in patients admitted to the emergency department with migraine.

Noninvasive Vagus Nerve Stimulation Effective for Episodic Migraines

Noninvasive Vagus Nerve Stimulation Effective for Episodic Migraines

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Researchers studied the effectiveness of a hand-held device designed to electrically stimulate the vagus nerve in the neck through the skin to treat episodic migraines.

Cervical Dysfunction Needs Clarification to Identify Link With Headache

Cervical Dysfunction Needs Clarification to Identify Link With Headache

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Future research is needed to determine whether cervical musculoskeletal dysfunction causes migraine or tension-type headache-related neck pain.

Ultrasound-Guided C2 Coblation May Be Effective for Cervicogenic Headache

Ultrasound-Guided C2 Coblation May Be Effective for Cervicogenic Headache

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Treatment of cervicogenic headache with ultrasound-guided C2 nerve root coblation was associated with significant reductions in pain for at least 24 weeks.

IASP Updates Diagnosis Criteria for Chronic Primary Pain for ICD-11

IASP Updates Diagnosis Criteria for Chronic Primary Pain for ICD-11

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The International Association for the Study of Pain updated its definitions for the diagnosis of chronic primary pain for the International Classification of Diseases, Eleventh Edition.

Researchers Identify Common Neurologic Manifestations in Fibromuscular Dysplasia

Researchers Identify Common Neurologic Manifestations in Fibromuscular Dysplasia

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Common and rare neurologic manifestations associated with fibromuscular dysplasia include migraine-type headaches, tinnitus, ischemic stroke, and transient ischemic attack.

Type 2 Diabetes Risk Lower in Women With Active Migraine

Type 2 Diabetes Risk Lower in Women With Active Migraine

Women with active migraine have a lower risk for type 2 diabetes.

Migraine With Aura Linked to Increase in Incident A-Fib

Migraine With Aura Linked to Increase in Incident A-Fib

Migraine with aura is associated with an elevated risk for incident atrial fibrillation.

Ticagrelor May Be Less Effective for Migraine Relief Than Thienopyridines

Ticagrelor May Be Less Effective for Migraine Relief Than Thienopyridines

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Investigators compared migraine response in participants taking ticagrelor vs participants taking a thienopyridine.

Headaches Identified as Potential Early Symptom of MS

Headaches Identified as Potential Early Symptom of MS

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Researchers found a high frequency and a high prevalence of headaches at the onset of multiple sclerosis symptoms that decreased significantly 6 months post diagnosis.

Continuing Treatment With Galcanezumab Benefits Those Initially Unresponsive

Continuing Treatment With Galcanezumab Benefits Those Initially Unresponsive

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For patients with episodic or chronic migraine who are initially unresponsive to galcanezumab, continued treatment may be associated with improvement.

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