Migraine and Headache

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Generalized Mechanical Hyperalgesia in Chronic Migraine, Temporomandibular Disorder

Generalized Mechanical Hyperalgesia in Chronic Migraine, Temporomandibular Disorder

Individuals with chronic migraine and temporomandibular disorder may have mechanical hyperalgesia in the trigeminal and extra-trigeminal regions.

Endothelial Dysfunction Biomarkers Elevated During Migraine Attacks in Women

Endothelial Dysfunction Biomarkers Elevated During Migraine Attacks in Women

Women may have greater carotid intima-media thickness and elevated levels of biomarkers of endothelial dysfunction during a migraine attack.

OnabotulinumtoxinA Effective in Reducing Depression and Anxiety Symptoms in Chronic Migraines

OnabotulinumtoxinA Effective in Reducing Depression and Anxiety Symptoms in Chronic Migraines

OnabotulinumtoxinA not only reduced headache frequency for patients with chronic migraines, but also showed potential for clinically reducing depression and anxiety symptoms.

OnabotulinumtoxinA Improves Outcomes in Chronic Migraine With or Without Allodynia

OnabotulinumtoxinA Improves Outcomes in Chronic Migraine With or Without Allodynia

OnabotulinumtoxinA treatment was found to reduce the frequency and severity of monthly headache days and to improve quality of life and disability in patients with chronic migraine with or without allodynia.

Cortical Thinning in Specific Brain Regions May Be Associated With Migraine

Cortical Thinning in Specific Brain Regions May Be Associated With Migraine

Establishing a biomarker, namely cortical thinning, for patients with migraine may help to classify phenotypes for the disease, such as aging.

New Research Further Explores Alcohol's Role as a Migraine Trigger

New Research Further Explores Alcohol's Role as a Migraine Trigger

Alcohol was a reported migraine trigger in 35.6% of participants, and approximately 25% of patients reported abstaining from alcohol because of its trigger effects.

Tosymra Approved for the Acute Treatment of Migraine

Tosymra Approved for the Acute Treatment of Migraine

The Food and Drug Administration has approved Tosymra for the acute treatment of migraines with or without aura in adults.

Migraine Symptoms Can Improve Despite Unchanged Pain Avoidance, Endurance

Migraine Symptoms Can Improve Despite Unchanged Pain Avoidance, Endurance

Improvements in headache frequency and disability may be observed in individuals with migraine without changes in pain avoidance or endurance behavior.

Galcanezumab Safe, Effective for Reducing Monthly Migraine Headache Days

Galcanezumab Safe, Effective for Reducing Monthly Migraine Headache Days

In patients with chronic migraine, monthly subcutaneous injections of galcanezumab at 120- and 240-mg doses were more effective than placebo for lowering the number of monthly migraine headache days.

Meta-Analysis: Botulinum A Injections Superior to Placebo for Chronic Migraine

Meta-Analysis: Botulinum A Injections Superior to Placebo for Chronic Migraine

For chronic migraine, botulinum type A injections are superior to placebo after three months of therapy.