Migraine & Headache News Archive

Questionnaire Reliably Predicts Effect of Migraine on Work-Related Duties

Questionnaire Reliably Predicts Effect of Migraine on Work-Related Duties

The use of the HEADWORK questionnaire may provide insight into the effects of migraines on work productivity and lost workdays.

Kinesiophobia May Be Associated With Greater Cutaneous Allodynia in Migraine

Kinesiophobia May Be Associated With Greater Cutaneous Allodynia in Migraine

Approximately half of patients with migraine have kinesiophobia, and the condition is associated with greater severity, not presence of cutaneous allodynia.

Topical Migraine Trigger Point Treatment as Effective as Injection

Topical Migraine Trigger Point Treatment as Effective as Injection

In a retrospective analysis, investigators assessed the effects of topical trigger point treatments on headache symptoms in patients with migraine.

A Potential Biomarker for Predicting Antibody Treatment Efficacy in Migraine

A Potential Biomarker for Predicting Antibody Treatment Efficacy in Migraine

Researchers showed high migraine induction capabilities with calcitonin gene-related peptide (CGRP) in people with migraine who responded to erenumab treatment compared to data from previous CGRP provocation experiments.

Serum Vitamin D Levels and Risk for Migraine

Serum Vitamin D Levels and Risk for Migraine

Higher levels of serum 25-hydroxyvitamin D may be associated with lower risk for migraine headaches.

Migraine Associated With Self-Reported ADHD Symptoms in University Students

Migraine Associated With Self-Reported ADHD Symptoms in University Students

Migraine may be associated with self-reported attention deficit and hyperactivity disorder symptoms in university students.

Erenumab as a Therapy for Hard to Treat Episodic Migraine

Erenumab as a Therapy for Hard to Treat Episodic Migraine

Erenumab 140 mg is a well-tolerated and potentially effective preventive treatment for patients with episodic migraine, according to a phase 3b study.

Higher Headache Medication Use Not Associated With Higher Achievement Motivation

Higher Headache Medication Use Not Associated With Higher Achievement Motivation

Study showed no evidence for an effect of achievement motivation on the frequency of acute headache medication use.

Genetic Risk Score Predicts Response to Triptans for Migraines Without Aura

Genetic Risk Score Predicts Response to Triptans for Migraines Without Aura

Genetic risk scores that focus on 2 single-nucleotide polymorphisms associated with migraines without aura might help predict patient response to triptan treatment.

Nonexpert Clinicians Lack Tools for Diagnosing Headache Disorders

Nonexpert Clinicians Lack Tools for Diagnosing Headache Disorders

There is a need for a tool in primary care to aid in managing and diagnosing headache disorders.

Assessing Headache Management Practices at Community Pharmacies

Assessing Headache Management Practices at Community Pharmacies

Counseling practices and headache management indicate the need for training and education of pharmacists in an Ethiopian city to better serve individuals with headache complaints.

Lasmiditan NDA Submitted for Acute Treatment of Migraine

Lasmiditan NDA Submitted for Acute Treatment of Migraine

The NDA submission included data from two Phase 3 trials, SAMURAI and SPARTAN.

IV Fluid Use Up, Narcotics Use Down in Patients With Migraine Admitted to ED

IV Fluid Use Up, Narcotics Use Down in Patients With Migraine Admitted to ED

A study looked at use of IV fluids, ketorolac, dexamethasone, and DRAs prochlorperazine/metoclopramide from 1999-2000 to 2014 in the treatment of patients with migraine admitted to the ED.

Pain Acceptance May Reduce Headache-Related Disability in Migraine

Pain Acceptance May Reduce Headache-Related Disability in Migraine

Improved pain acceptance may be associated with a decrease in headache-related disability in patients with migraine.

Nonsinogenic Headache vs Chronic Rhinosinusitis Differential Diagnosis Based on SNOT-22 Patterns

Nonsinogenic Headache vs Chronic Rhinosinusitis Differential Diagnosis Based on SNOT-22 Patterns

Distinct response patterns of the 22-item Sino-Nasal Outcome Test may be used to distinguish nonsinogenic headaches from chronic rhinosinusitis.

The Comorbidity of Migraine and ADHD: Is There a Link?

The Comorbidity of Migraine and ADHD: Is There a Link?

Investigators examined the link between migraine and attention-deficit/hyperactivity disorder.

Opioid Prescription Rates for Pediatric Headaches Vary by Provider Specialty

Opioid Prescription Rates for Pediatric Headaches Vary by Provider Specialty

Investigators examined opioid prescribing trends in children and adolescents with primary headaches during ambulatory and emergency department visits.

Documentation Initiative Improves Headache Treatment and Research

Documentation Initiative Improves Headache Treatment and Research

The authors built a customized structured clinical documentation support toolkit that collects hundreds of fields of discrete, standardized data.

Pulse Focused Ultrasound: A Potential Therapeutic Option for Migraines

Pulse Focused Ultrasound: A Potential Therapeutic Option for Migraines

Investigators aim to develop a non-invasive treatment for medically refractory chronic migraine not requiring a permanent implant.

Migraine Subgroups Indentified Based on Comorbidity Profiles

Migraine Subgroups Indentified Based on Comorbidity Profiles

Investigators identify subgroups of individuals with migraine based on comorbidities and concomitant condition.

Privacy Issues in Headache and Migraine Smartphone Applications

Privacy Issues in Headache and Migraine Smartphone Applications

Many headache smartphone applications or "apps" share information with third parties, more than half of which have privacy policies stating that the shared data will be used to serve targeted advertisements from third parties.

Freedom From Most Bothersome Headache-Associated Symptom Feasible as Primary End Point

Freedom From Most Bothersome Headache-Associated Symptom Feasible as Primary End Point

Investigators examine most bothersome headache-associated symptoms as a feasible alternative to using 4 c-primary end points in acute migraine treatment trials.

Co-Prescription of Opioids and Antidepressants Prevalent in Migraine

Co-Prescription of Opioids and Antidepressants Prevalent in Migraine

Researchers sought to assess the prevalence of concomitant prescribing of opioid analgesics with a triptan or a serotogeneric antidepressant in individuals with migraine.

New Device Available for Patients With Episodic Cluster Headache, Migraine

New Device Available for Patients With Episodic Cluster Headache, Migraine

The Sapphire has a rechargeable and reloadable fill capacity; it can be activated monthly by inputting a unique, prescription-only authorization code, delivered via a radio-frequency identification card that is mailed to the patient.

Migraine Associated With Increased Risk for Postsurgical 30-Day Hospital Readmission for Pain

Migraine Associated With Increased Risk for Postsurgical 30-Day Hospital Readmission for Pain

Patients with migraine headaches—particularly those accompanied by aura—may be at significantly increased risk for 30-day hospital readmission because of pain after surgery.

Overuse of Neuroimaging in the Emergency Department Reported for Pediatric Headache

Overuse of Neuroimaging in the Emergency Department Reported for Pediatric Headache

Investigators examined rates, predictors, and outcomes of neuroimaging in pediatric and adolescent patients who presented to the ED with a headache.

Erenumab May Help Prevent Migraines in Patients With Heart Disease

Erenumab May Help Prevent Migraines in Patients With Heart Disease

Investigators assessed the effect of erenumab on total exercise time, time to exercise-induced angina, and ST depression in patients with stable angina.

No Significant Clinical Differences Between Cluster Headaches With and Without Aura

No Significant Clinical Differences Between Cluster Headaches With and Without Aura

No significant clinical differences have been found between individuals with cluster headache who experience aura vs no aura.

Hemiplegic Migraine Aura Alleviated by OnabotulinumtoxinA Injections

Hemiplegic Migraine Aura Alleviated by OnabotulinumtoxinA Injections

Investigators examined the effect of onabotulinumtoxinA on aura frequency and severity in patients with hemiplegic migraine.

Oral Steroids Perform Better Than Injection in Short-Term Cluster Headache Management

Oral Steroids Perform Better Than Injection in Short-Term Cluster Headache Management

Investigators examined the efficacy of oral steroids and greater occipital nerve injections as transitional therapies for cluster headache management.

Migraine Pain Location May Not Have Clinical Implications

Migraine Pain Location May Not Have Clinical Implications

The location of migraine pain may not be associated with psychiatric distress, emergency department visits, or healthcare use.

Adverse Childhood Events Associated With Medication Overuse Headache

Adverse Childhood Events Associated With Medication Overuse Headache

Known risk factors for medication overuse headache include smoking, anxiety, family history of substance abuse, migraine history, depression, and obsessive-compulsive disorder.

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

Carefully assessing cognitive performance using a screening test to detect visuospatial/executive, attention, and memory dysfunction in patients with migraine.

Headache Frequency May Predict Treatment Success in Pediatric Migraine

Headache Frequency May Predict Treatment Success in Pediatric Migraine

The odds of first-line treatment success in pediatric migraine may be lower in patients who have higher baseline headache frequency and medication overuse headache.

Ketamine Infusions May Be Effective for Refractory Headache

Ketamine Infusions May Be Effective for Refractory Headache

For many patients with refractory headache, ketamine treatment may provide short-term analgesia with tolerable adverse events.

Two-Thirds of Parents Report Their Child Has Had Headache

Two-Thirds of Parents Report Their Child Has Had Headache

Two-thirds of parents report that their child has had a headache not related to a fall or head injury.

Men With Migraines May Have Increased Serum Estradiol, Androgen Deficiency

Men With Migraines May Have Increased Serum Estradiol, Androgen Deficiency

Men with migraines were found to have increased levels of estradiol and to be more likely to have relative androgen deficiency compared with men without migraines.

Fremanezumab Effective in Reversion of Chronic Migraine to Episodic Migraine

Fremanezumab Effective in Reversion of Chronic Migraine to Episodic Migraine

This Phase III, multicenter, double-blind study sought to explore the effect of fremanezumab on the potential reversion from chronic migraine to episodic migraine.

Cardiovascular, Psychiatric Comorbidity Patterns Evident in Migraine

Cardiovascular, Psychiatric Comorbidity Patterns Evident in Migraine

The comorbidities commonly reported in patients with migraine include those involving cardiovascular, psychiatric, pain, and respiratory conditions, the researchers reported.

Erenumab Reduces Monthly Migraine Days in Patients With Treatment-Resistant Migraine

Erenumab Reduces Monthly Migraine Days in Patients With Treatment-Resistant Migraine

Patients with difficult-to-treat migraine were randomly assigned 1:1 to either 140 mg erenumab or placebo.

Rimegepant Shows Efficacy and Safety in Treating Acute Migraine

Rimegepant Shows Efficacy and Safety in Treating Acute Migraine

Rimegepant is a safe and efficacious pharmacological treatment of acute migraine in adults.

OnabotulinumtoxinA May Be Effective for Chronic Migraine With Medication Overuse

OnabotulinumtoxinA May Be Effective for Chronic Migraine With Medication Overuse

OnabotulinumtoxinA at 195 UI may be effective in reducing the number of headaches per month and medication intake in patients with chronic migraine and medication overuse.

Half of Patients Referred for Behavioral Treatment of Migraine Never Initiate Treatment

Half of Patients Referred for Behavioral Treatment of Migraine Never Initiate Treatment

Approximately half of patients who were referred for behavioral treatment for migraine were found to initiate treatment.

Low-Dose Sumatriptan Injection Effective as Acute Migraine Treatment

Low-Dose Sumatriptan Injection Effective as Acute Migraine Treatment

A phase 3 study examined a low-dose subcutaneous autoinjection of sumatriptan in the acute treatment of migraines with or without aura in adults.

Poll: Should Migraineurs Avoid Headache Triggers?

Poll: Should Migraineurs Avoid Headache Triggers?

Dr Richard Lipton and Dr Paul Martin debated the pros and cons of trigger avoidance in patients with migraine headache at the 2018 American Headache Society Annual Scientific Meeting in San Francisco, California.

History of Migraine May Be Associated With Higher Risk for Cochlear Disorders

History of Migraine May Be Associated With Higher Risk for Cochlear Disorders

The risk for cochlear disorders — particularly tinnitus — may be higher in individuals with a history of migraine.

Erenumab Remains Safe, Tolerable Over 3-Plus Years of Treatment in Episodic Migraine

Erenumab Remains Safe, Tolerable Over 3-Plus Years of Treatment in Episodic Migraine

In their interim analysis of a 5-year open-label extension trial, study investigators evaluated the safety and tolerability of erenumab treatment in episodic migraine patients who completed ≥3 years of the trial or discontinued treatment.

Chronic Migraine Burden Has Significant Impact on Relationships, Family Life

Chronic Migraine Burden Has Significant Impact on Relationships, Family Life

The CaMEO study is a prospective, longitudinal web-based survey designed to characterize the impact of migraine on aspects of quality of life.

Novel Oral Treatment Safe, Effective for Migraine Headache Relief

Novel Oral Treatment Safe, Effective for Migraine Headache Relief

The 2 randomized, phase 3, double-blind studies included in this presentation were the SAMURAI and SPARTAN trials.

Chronic Migraine Associated With Age-Related Changes in Cortical Thickness

Chronic Migraine Associated With Age-Related Changes in Cortical Thickness

Individuals with chronic migraine may present with age-related changes in cortical thickness.

Posttraumatic Headaches More Severe, Frequent Than Nontraumatic Headaches

Posttraumatic Headaches More Severe, Frequent Than Nontraumatic Headaches

The investigators assessed participants for photophobia, unilateral location, phonophobia, exacerbation, nausea, pulsatility, sensory aura, pain level and frequency, visual aura, and allodynia features.

Color-Selective Photophobia More Prevalent During Ictal vs Interictal Phase

Color-Selective Photophobia More Prevalent During Ictal vs Interictal Phase

Color-selective photophobia was found to be more prevalent during the ictal vs interictal phase in individuals with migraine.

DFN-02 Nasal Spray Safe, Effective for Acute Treatment of Episodic Migraine

DFN-02 Nasal Spray Safe, Effective for Acute Treatment of Episodic Migraine

DFN-02 nasal spray may be effective, well tolerated, and safe for the acute treatment of episodic migraine.

Ubrogepant Reduces Acute Migraine Pain, Symptoms

Ubrogepant Reduces Acute Migraine Pain, Symptoms

Results from the ACHIEVE II study were presented at the American Headache Society's 60th Annual Scientific Meeting.

Fremanezumab May Help Reduce Medication Overuse in Chronic Migraine

Fremanezumab May Help Reduce Medication Overuse in Chronic Migraine

Treatment with fremanezumab may help reduce medication overuse and the number of days of acute medication use in individuals with chronic migraine.

Eptinezumab May Provide Fast, Effective Reduction of Monthly Migraine Days

Eptinezumab May Provide Fast, Effective Reduction of Monthly Migraine Days

Eptinezumab has shown 100% bioavailability when administered intravenously.

Greater Occipital Nerve Block Effective for Acute Relief of Refractory Migraine

Greater Occipital Nerve Block Effective for Acute Relief of Refractory Migraine

The treatment may be beneficial in patients whose acute migraine does not respond to standard treatment with intravenous metoclopramide.

Rapid Treatment Onset, Reduced Headache Days With Galcanezumab

Rapid Treatment Onset, Reduced Headache Days With Galcanezumab

In the post-hoc analysis, researchers evaluated the time to onset of effect of galcanezumab as well as whether treatment with the study drug was associated with a reduction in migraine headache days.

Headache Calendar Helps Patients Track Relationship Between Headache, Triggers

Headache Calendar Helps Patients Track Relationship Between Headache, Triggers

This cross-sectional, observational study sought to evaluate the accuracy of individuals with headache to appraise the relationship between potential trigger factors and headache events.

Intravenous Eptinezumab Effectively Reduces Monthly Migraine Days

Intravenous Eptinezumab Effectively Reduces Monthly Migraine Days

More patients in the 100 mg and 300 mg eptinezumab groups achieved a 100% reduction in monthly migraine days over the 112 weeks compared with placebo.

OnabotulinumtoxinA Safer, More Effective for Headache Prevention Than Topiramate

OnabotulinumtoxinA Safer, More Effective for Headache Prevention Than Topiramate

This randomized, open-label study examined participant reported outcomes, safety, and tolerability of onabotulinumtoxinA and topiramate in adults with chronic migraines.

Fremanezumab Reduces Monthly Migraine Days in Chronic Migraine

Fremanezumab Reduces Monthly Migraine Days in Chronic Migraine

Fremanezumab has shown efficacy in safely reducing monthly headache days in individuals with chronic migraine.

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

Menopause Transition Often Prompts Changes in Migraine Pattern, Characteristics

This retrospective study sought to assess migraine patterns in 69 menopausal women between ages 40 and 60 who were treated at Partners Healthcare Hospitals for concurrent migraine headache.

Transcutaneous Electrical Nerve Stimulation May Be Effective for Migraine

Transcutaneous Electrical Nerve Stimulation May Be Effective for Migraine

Transcutaneous electrical nerve stimulation may represent an effective treatment for the prevention and management of migraine.

Transnasal Sphenopalatine Ganglion Block May Be Safe, Effective for Acute Migraine Treatment

Transnasal Sphenopalatine Ganglion Block May Be Safe, Effective for Acute Migraine Treatment

The use of transnasal sphenopalatine ganglion block is safe and effective for providing short-term relief from acute migraine headaches.

Polypharmacy in Primary Headache Risks Chronicization and Further Complications

Polypharmacy in Primary Headache Risks Chronicization and Further Complications

Polypharmacy in individuals with primary headache may arise out of a prescribing cascade.

Diagnosis and Treatment of Migraine in Children Should Consider Atopy

Diagnosis and Treatment of Migraine in Children Should Consider Atopy

Clinical evidence supports a strong relationship between cephalalgic migraine and allergic rhinitis in children.

Sleep Quality in Chronic Tension-Type Headaches

Sleep Quality in Chronic Tension-Type Headaches

Investigators examined baseline and 1-year variables and their association with quality of sleep in chronic tension-type headaches.

Cannabis Use High in Migraine

Cannabis Use High in Migraine

A high percentage of cannabis users take the drug to treat headache and probable migraine.

Self-Detoxification From Overuse of Headache Medications Reduces Disability

Self-Detoxification From Overuse of Headache Medications Reduces Disability

Medication overuse headache may be a significant disease burden in the general population.

Neurologist-Patient Dialogues About Chronic Migraine Lacking Crucial Elements

Neurologist-Patient Dialogues About Chronic Migraine Lacking Crucial Elements

Investigators collected audio recording of physician-patient interaction during office visits to evaluate communication patterns.

No Strong Causal Relationship Between Smoking and Headaches

No Strong Causal Relationship Between Smoking and Headaches

Investigators sought to determine the association between smoking and headache.

Subclinical Hypothyroidism May Increase Migraine Development Risk

Subclinical Hypothyroidism May Increase Migraine Development Risk

This study sought to further examine the association between migraine and subclinical hypothyroidism.

Brainstem Parasympathetic Dysregulation May Have Role in Migraine Pathophysiology

Brainstem Parasympathetic Dysregulation May Have Role in Migraine Pathophysiology

Investigators examined the cranial autonomic nervous system in patients with migraine by applying the cold pressor test.

Discerning Arterial Ischemic Stroke From Migraine in Pediatric Emergency Departments

Discerning Arterial Ischemic Stroke From Migraine in Pediatric Emergency Departments

Investigators examined presenting features of migraine vs arterial ischemic stroke in children presenting to the emergency department.

Restless Leg Syndrome, Fibromyalgia, and Depression Frequent in Migraine

Restless Leg Syndrome, Fibromyalgia, and Depression Frequent in Migraine

Patients with migraine may exhibit higher prevalence of restless leg syndrome, fibromyalgia, and depressive symptoms compared with individuals not experiencing migraines.

Levetiracetam Effective as Episodic Migraine Prophylactic

Levetiracetam Effective as Episodic Migraine Prophylactic

The antiepileptic drug levetiracetam may represent an effective prophylactic treatment option for episodic migraine.

Effect of Job Characteristics on Work Ability in Patients With Chronic Headaches

Effect of Job Characteristics on Work Ability in Patients With Chronic Headaches

Lower work ability in patients with chronic migraine may be associated with high quantitative and emotional demand.

Trigger Point Manual Treatments May Be Effective in Tension-Type Headache

Trigger Point Manual Treatments May Be Effective in Tension-Type Headache

Manual trigger point treatments of head and neck muscles may be associated with reductions in the duration, frequency, and intensity of tension-type headache and migraine headache attacks.

Effects of Prenatal Triptan Exposure on Neurodevelopment in Children

Effects of Prenatal Triptan Exposure on Neurodevelopment in Children

Investigators aimed to find the link between exposure to triptans in utero and externalizing behavior, internalizing behavior, communication, and temperament in children.

CBT for Insomnia May Reduce Headache Frequency in Chronic Migraine

CBT for Insomnia May Reduce Headache Frequency in Chronic Migraine

In patients with comorbid insomnia and chronic migraine, a cognitive behavioral treatment of insomnia may effectively reduce headache frequency.

Remission Rates and Predictors of Chronic Headache

Remission Rates and Predictors of Chronic Headache

Investigators examined remission rates and predictors of remission in patients with chronic headache over 11 years.

Neck Pain a Migraine Symptom, Rather Than a Migraine Trigger

Neck Pain a Migraine Symptom, Rather Than a Migraine Trigger

Neck pain is a symptom of migraine only, not the result of an underlying muscle dysfunction that triggers migraine attacks.

Qualitative Analysis of Visual Symptoms in Childhood Migraine

Qualitative Analysis of Visual Symptoms in Childhood Migraine

Investigators examined the characteristics of visual symptoms during migraine attacks in children and adolescents.

Intravenous Aminophylline Safe and Effective for Postdural Puncture Headache

Intravenous Aminophylline Safe and Effective for Postdural Puncture Headache

Investigators examine the safety and efficacy of intravenous aminophylline for postdural puncture headaches.

FDA Approves Aimovig for Migraine Prevention

FDA Approves Aimovig for Migraine Prevention

The first-in-class migraine prevention drug will be available to patients within 1 week of the approval.

Increased Risk for Developing Hypertension in Women With Migraine

Increased Risk for Developing Hypertension in Women With Migraine

Investigators conducted a prospective cohort study to examine the risk of incident hypertension in women with migraine.

NPRS, Neck Disability Index: Reliable Assessment Tools in the Short-Term

NPRS, Neck Disability Index: Reliable Assessment Tools in the Short-Term

The Neck Disability Index, and to a lesser extent, the Numeric Pain Rating Scale, may represent reliable measures for patients to self-report cervicogenic headache-associated disability and pain in the short-term.

Migraine Linked With Increased Long-Term Cardiovascular, Cerebrovascular Event Risk

Migraine Linked With Increased Long-Term Cardiovascular, Cerebrovascular Event Risk

Migraine headache is associated with a higher risk for major adverse cardiovascular and cerebrovascular events.

Galcanezumab Effective in Phase 3 Episodic Cluster Headache Study

Galcanezumab Effective in Phase 3 Episodic Cluster Headache Study

The episodic cluster headache trial included a total of 106 patients with an average of 17.5 cluster headache attacks per week at baseline.

Enhanced Activation of the Spinal Trigeminal Nucleus in Chronic Migraine During Visual Stimulation

Enhanced Activation of the Spinal Trigeminal Nucleus in Chronic Migraine During Visual Stimulation

Patients with chronic migraine exposed to visual stimulation may have enhanced activity in the spinal trigeminal nucleus and the right superior colliculus compared with healthy individuals.

Migraine a Common Comorbidity in Individuals With Sarcoidosis

Migraine a Common Comorbidity in Individuals With Sarcoidosis

The frequency of migraine and sarcoidosis comorbidity was examined in a cohort study.

Beneficial Effect of Aerobic Exercise in Migraine via Modulation of Avoidance Behavior

Beneficial Effect of Aerobic Exercise in Migraine via Modulation of Avoidance Behavior

The effect of aerobic exercise in reducing migraine-associated burden in individuals with comorbid tension-type headache and neck pain may not be mediated by an effect on nociceptive pathways.

Antidepressant Medications and Headache: Is There a Link?

Antidepressant Medications and Headache: Is There a Link?

Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).

Aerobic Exercise Significantly Improves Symptom Burden for Migraineurs

Aerobic Exercise Significantly Improves Symptom Burden for Migraineurs

Aerobic exercise may improve migraine frequency, intensity of pain, and the duration of tension-type headache.

Repeat Masseter NGF Injection May Result in Increased Pain Sensitivity

Repeat Masseter NGF Injection May Result in Increased Pain Sensitivity

Repeated injections of nerve growth factor may lead to increased mechanical sensitivity in the masseter — but not in the temporalis muscle — as well as increased entropy.

Avoiding Treatment Effect Overestimation in Medication-Overuse Headache

Avoiding Treatment Effect Overestimation in Medication-Overuse Headache

A period of observation after an educational session may be important to confirm medication-overuse headache (MOH) diagnoses.

Hormonal Factors May Affect Intensity of Migraine During Pregnancy

Hormonal Factors May Affect Intensity of Migraine During Pregnancy

Researchers aim to determine a pattern of migraine, in terms of frequency, intensity, and analgesic use, in women with and without menstrual migraine.

Eptinezumab for Frequent Episodic Migraine: Results of Phase 3 PROMISE-1 Study

Eptinezumab for Frequent Episodic Migraine: Results of Phase 3 PROMISE-1 Study

Eptinezumab, a humanized monoclonal antibody specific to calcitonin gene-related peptide, may be an effective prophylactic for individuals with frequent episodic migraines.

OnabotulinumtoxinA May Reduce Headache Days in Chronic Migraine

OnabotulinumtoxinA May Reduce Headache Days in Chronic Migraine

Treating chronic migraine with onabotulinumtoxinA may reduce the number of headache days when administered according to the National Institute for Health and Care Excellence guidelines.

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