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Megestrol Tablets
Breast cancer
Gynecologic cancers
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Drug Name:

Megestrol Tablets Rx

Generic Name and Formulations:
Megestrol acetate 20mg, 40mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Megestrol Tablets:

Palliative treatment of advanced breast carcinoma.

Adult:

40mg 4 times daily.

Children:

Not applicable.

Contraindications:

Pregnancy.

Warnings/Precautions:

History of thromboembolic disease. Diabetes. Monitor for adrenal insufficiency. Fetal toxicity. Obtain (–) pregnancy test prior to initiation. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: not recommended.

Pharmacological Class:

Progestin.

Interactions:

May increase insulin requirements. Decreases indinavir levels.

Adverse Reactions:

Weight gain, thromboembolic events, heart failure, GI upset, edema, breakthrough menstrual bleeding, dyspnea, tumor flare, hyperglycemia, alopecia, hypertension, carpal tunnel syndrome, mood changes, hot flashes, malaise, asthenia, lethargy, sweating, rash.

Note:

Formerly known under the brand name Megace.

How Supplied:

Contact supplier.

Indications for Megestrol Tablets:

Palliative treatment of advanced endometrial carcinoma.

Adult:

40–320mg daily in divided doses.

Children:

Not applicable.

Contraindications:

Pregnancy.

Warnings/Precautions:

History of thromboembolic disease. Diabetes. Monitor for adrenal insufficiency. Fetal toxicity. Obtain (–) pregnancy test prior to initiation. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: not recommended.

Pharmacological Class:

Progestin.

Interactions:

May increase insulin requirements. Decreases indinavir levels.

Adverse Reactions:

Weight gain, thromboembolic events, heart failure, GI upset, edema, breakthrough menstrual bleeding, dyspnea, tumor flare, hyperglycemia, alopecia, hypertension, carpal tunnel syndrome, mood changes, hot flashes, malaise, asthenia, lethargy, sweating, rash.

Note:

Formerly known under the brand name Megace.

How Supplied:

Contact supplier.

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