LOPRESSOR Rx

Indications for LOPRESSOR:

Long-term management of angina.

Adult:

Take with meals. Initially 100mg daily in 2 divided doses. May be increased weekly, if needed. Usual range: 100–400mg/day.

Children:

Not recommended.

Contraindications:

Sinus bradycardia. 2^nd- or 3^rd-degree AV block. Overt heart failure. Cardiogenic shock. Sick-sinus syndrome. Severe peripheral arterial circulatory disorders.

Boxed Warning:

Avoid abrupt discontinuation in ischemic heart disease.

Warnings/Precautions:

CHF. Ischemic heart disease. Monitor heart rate and rhythm; reduce or stop treatment if severe bradycardia develops. Bronchospastic disease. Hepatic dysfunction. Diabetes. Pheochromocytoma. Hyperthyroidism. Surgery. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Beta-blocker.

Interactions:

Bradycardia with catecholamine-depleting drugs. May be potentiated by potent CYP2D6 inhibitors (eg, fluoxetine, paroxetine, bupropion, thioridazine, quinidine, propafenone, ritonavir, diphenhydramine, hydroxychloroquine, terbinafine, cimetidine), hydralazine, inhalation anesthetics. Increased risk of bradycardia with concomitant digitalis. May block epinephrine. Increased rebound hypertension with clonidine withdrawal. May enhance vasoconstrictive action of ergots. Withhold before dipyridamole testing.

Adverse Reactions:

Fatigue, dizziness, depression, diarrhea, rash, dyspnea, bradycardia, cold extremities, palpitations, CHF, peripheral edema, hypotension, bronchospasm, heart block.

How Supplied:

Tabs—100

Indications for LOPRESSOR:

In stabilized patients after MI, to reduce mortality.

Adult:

See literature. Early treatment: initially administer three 5mg IV bolus inj given at approximately 2-minute intervals; monitor BP, HR, ECG. If full IV dose (15mg) tolerable, give 50mg (tab) every 6 hours starting 15 mins after the last IV dose and continue for 48 hours, thereafter, give maintenance dose of 100mg (tab) twice daily; if full IV dose not tolerable, give 25–50mg (tab) every 6 hours starting 15 mins after the last IV dose or as soon as clinical condition allows; if severe intolerance: discontinue treatment. Late treatment: if early phase treatment is contraindicated, intolerable or delayed therapy needed, start with 100mg (tab) twice daily for at least three months.

Children:

Not recommended.

Contraindications:

Significant 1^st degree heart block. 2^nd- or 3^rd-degree AV block. Systolic pressure<100mmHg or heart rate <45 beats/min. Moderate-to-severe cardiac failure.

Boxed Warning:

Avoid abrupt discontinuation in ischemic heart disease.

Warnings/Precautions:

CHF. Monitor heart rate and rhythm; reduce or stop treatment if severe bradycardia develops. Bronchospastic disease. Hepatic dysfunction. Diabetes. Pheochromocytoma. Hyperthyroidism. Surgery. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

See Also:

LOPRESSOR INJECTION

Pharmacological Class:

Beta-blocker.

Interactions:

Bradycardia with catecholamine-depleting drugs. May be potentiated by potent CYP2D6 inhibitors (eg, fluoxetine, paroxetine, bupropion, thioridazine, quinidine, propafenone, ritonavir, diphenhydramine, hydroxychloroquine, terbinafine, cimetidine), hydralazine, inhalation anesthetics. Increased risk of bradycardia with concomitant digitalis. May block epinephrine. Increased rebound hypertension with clonidine withdrawal. May enhance vasoconstrictive action of ergots. Withhold before dipyridamole testing.

Adverse Reactions:

Fatigue, dizziness, depression, hypotension (discontinue if occurs), diarrhea, rash, dyspnea, bradycardia, cold extremities, palpitations, CHF, peripheral edema, bronchospasm, heart block.

How Supplied:

Tabs—100; Ampuls (5mL)—10

Indications for LOPRESSOR:

Hypertension.

Adult:

Take with meals. Initially 100mg daily in 1–2 divided doses. May be increased weekly, if needed. Usual range: 100–450mg/day.

Children:

Not recommended.

Contraindications:

Sinus bradycardia. 2^nd- or 3^rd-degree AV block. Overt heart failure. Cardiogenic shock. Sick-sinus syndrome. Severe peripheral arterial circulatory disorders.

Boxed Warning:

Avoid abrupt discontinuation in ischemic heart disease.

Warnings/Precautions:

CHF. Ischemic heart disease. Monitor heart rate and rhythm; reduce or stop treatment if severe bradycardia develops. Bronchospastic disease. Hepatic dysfunction. Diabetes. Pheochromocytoma. Hyperthyroidism. Surgery. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Cardioselective beta-blocker.

Interactions:

Bradycardia with catecholamine-depleting drugs. May be potentiated by potent CYP2D6 inhibitors (eg, fluoxetine, paroxetine, bupropion, thioridazine, quinidine, propafenone, ritonavir, diphenhydramine, hydroxychloroquine, terbinafine, cimetidine), hydralazine, inhalation anesthetics. Increased risk of bradycardia with concomitant digitalis. May block epinephrine. Increased rebound hypertension with clonidine withdrawal. May enhance vasoconstrictive action of ergots. Withhold before dipyridamole testing.

Adverse Reactions:

Fatigue, dizziness, depression, diarrhea, rash, dyspnea, bradycardia, cold extremities, palpitations, CHF, peripheral edema, hypotension, bronchospasm, heart block.

How Supplied:

Tabs—100