Generic Name and Formulations:
Mesalamine 1.2g; del-rel tabs.
Shire US, Inc.
Indications for LIALDA:
To induce remission in active, mild-to-moderate ulcerative colitis; and to maintain remission of ulcerative colitis.
≥18yrs: Swallow whole with a meal. 2.4–4.8g once daily for up to 8 weeks. Maintenance: 2.4g once daily.
<18yrs: not established.
Sulfasalazine allergy. Upper GI tract obstruction (eg, pyloric stenosis) may delay onset of action. Discontinue if acute intolerance syndrome is suspected. Conditions predisposing to myocarditis or pericarditis. Atopic dermatitis or eczema: may have more severe photosensitivity reactions. Renal or hepatic impairment. Monitor renal function prior to and periodically during therapy. Elderly (monitor CBCs). Pregnancy (Cat.B). Nursing mothers.
Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk of blood disorders with azathioprine or 6-mercaptopurine. May cause elevated test results in measuring urinary normetanephrine.
Ulcerative colitis, headache, flatulence, abnormal LFTs, abdominal pain; acute intolerance syndrome (cramping, bloody diarrhea, fever, headache, rash), renal impairment, cardiac hypersensitivity reactions, pancreatitis (rare).
Clinical Pain Advisor Articles
- Abuse-Deterrent Opioid Formulations: Barriers to Broader Use
- Notifications by PDMPs May Not Effectively Reduce Opioid Misuse
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Medical Cannabis Legalization Associated With Reduced Schedule III Opioid Prescriptions
- Electroacupuncture May Help Reduce Opioid Use in Chronic Musculoskeletal Pain
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- Opioid Use Disorder Prevalence at Delivery on the Rise in the US, According to CDC
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Pharmacologically Induced Headache Accompanied by Dilated Cephalic Vessels
- IV Lidocaine May Be Safe, Efficacious for Pediatric Status Migraine
- Gray Matter Changes in Migraine Associated With Clinical Characteristics