Higher PainDETECT Scores, Neuropathic Pain Preoperatively May Increase Risk for Chronic Pain Post-TKRJuly 20, 2018
Individuals with knee osteoarthritis who have indicators of high vs low/no levels of neuropathic pain may be at elevated risk for chronic pain after total knee replacement surgery.
Neuropathic-like symptoms may affect pain-related quality of life ratings and function in patients with hip and knee osteoarthritis, respectively.
For overweight and obese older adults with knee osteoarthritis, greater weight loss is associated with superior clinical and mechanistic outcomes.
Zoledronic acid did not significantly reduce knee pain or bone marrow lesion size overall in patients with knee osteoarthritis over 24 months.
A set of psychosocial and sociodemographic factors may be associated with pain levels in patients with knee osteoarthritis.
Patients who received a repeat Zilretta injection experienced a 64% improvement in Western Ontario and McMaster Universities Arthritis Index (WOMAC)-A (pain), a 66% improvement in WOMAC-B (stiffness), a 64% improvement on WOMAC-C (function), and improvement represented by a doubling of the KOOS Quality of Life subscale score by Week 4.
Genicular nerve cooled radiofrequency ablation may effectively relieve chronic knee pain associated with osteoarthritis and improve function for up to 6 months.
Laparoscopic gastric band surgery is associated with more improvement in knee osteoarthritis in younger patients and those without prior knee injury.
Intravenous and subcutaneous administration of tanezumab may provide similar analgesia and tolerability in patients with hip or knee osteoarthritis.
Improvement in pain at one month; decrease in global WOMAC score in eight patients after GAE
Opioids and nonopioid analgesics were found to provide similar improvements in pain-related function over a 1-year period in patients with chronic back pain or knee or hip osteoarthritis pain.
Patients with knee osteoarthritis who can best benefit from treatment with intra-articular hyaluronic acid injections include patients with high levels of knee pain, younger individuals, persons with a high body mass index, and individuals with less severe structural damage.
In patients with knee osteoarthritis, high pain levels and low pressure pain thresholds at baseline predicted worse pain outcomes after total knee replacement surgery, but did not predict outcomes after nonsurgical interventions.
The study compared opioid vs non-opioid treatment in 240 patients with either moderate to severe chronic back pain or hip or knee osteoarthritis pain.
This study's results revealed that tai chi and physical therapy interventions did not differ in time-to-response according to either ≥20% or ≥50% response thresholds for pain or function.
Pain expectancy may affect the pain experience in older patients with knee osteoarthritis after genuine and sham electroacupuncture.
Patients with end-stage knee or hip osteoarthritis were found to often experience possible neuropathic pain - particularly pain at rest vs on activity, and in men.
Seven studies were included in a meta-analysis examining the potential benefit of bisphosphonate therapy in knee osteoarthritis.
The FDA has granted Fast Track designation to CNTX-4975, a highly potent, ultrapure, synthetic form of trans-capsaicin, for the treatment of pain associated with knee osteoarthritis.
Cooled radiofrequency ablation may provide greater pain relief compared with intraarticular steroid injection in patients with osteoarthritis-related chronic knee pain.
Flexion Therapeutics announced the availability of Zilretta (triamcinolone acetonide extended-release injectable suspension) indicated for the management of pain associated with osteoarthritis (OA) of the knee.
The FDA has approved Durolane for the treatment of pain associated with knee osteoarthritis, which relieved pain and restored function for up to 6 months in patients.
Intra-articular ozone may provide pain relief, functional improvement, and gains in quality of life in patients with knee osteoarthritis.
Approximately 37% of US adults aged 60 years and older have been diagnosed with knee osteoarthritis, and the number is expected to rise.
Patients with knee osteoarthritis and severe comorbidities showed significant improvements in physical function shown by WOMAC and 6MWT scores after undergoing a tailored exercise program.
Chondroitin sulfate was superior to placebo and proved equivalent to celecoxib for osteoarthritis of the knee.
Fiber and/or the dietary supplement chondroitin may help reduce knee pain from arthritis.
A quadriceps isometric contraction exercise method is effective for relieving pain in knee osteoarthritis.
Transcranial direct current stimulation can effectively alleviate osteoarthritis-related knee pain.
Novel viscous gel-based formulation of hyaluronan more effective in reducing pain and stiffness in patients with moderate knee osteoarthritis.
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