Generic Name and Formulations:
Sodium polystyrene sulfonate; pwd; sodium content 4.1mEq/g.
Concordia Pharmaceuticals Inc.
Indications for KAYEXALATE:
Limitations Of use:
Not for treating life-threatening hyperkalemia due to its delayed onset of action.
See full labeling. Oral: give in an upright position; 15g as a suspension 1–4 times daily. Rectal enema: 30–50g in 100mL every 6hrs.
See full labeling. 1g per 1mEq of potassium as basis of calculation may be used.
Obstructive bowel disease. Neonates with reduced gut motility.
Avoid in patients at risk for constipation/impaction (eg, history of impaction, chronic constipation, inflammatory bowel disease, ischemic colitis, vascular intestinal atherosclerosis, previous bowel resection, bowel obstruction); discontinue if constipation develops. Post-surgery: avoid if have not had a bowel movement. CHF, hypertension, edema: monitor for fluid overload. Risk of aspiration. Monitor electrolytes (eg, potassium, calcium, magnesium). Neonates: do not give by oral route. Infants.
Cation exchange resin.
Increased risk of intestinal necrosis with concomitant sorbitol; not recommended. Separate dosing by ≥3hrs before or ≥3hrs after other oral drugs (6hrs in patients with gastroparesis). Increased risk of systemic alkalosis with nonadsorbable cation-donating antacids and laxatives. Reduces absorption of thyroxine, lithium.
Anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), ischemic colitis, nausea, vomiting; intestinal necrosis, electrolyte disturbances.
Clinical Pain Advisor Articles
- Manual Therapy vs Opioids for Management of Shoulder, Spine Pain
- Kinesiophobia May Be Associated With Greater Cutaneous Allodynia in Migraine
- PainDETECT May Not Be Optimal to Detect Neuropathic Components of Orofacial Pain
- Topical Migraine Trigger Point Treatment as Effective as Injection
- Chronic Spinal Pain and Depression: Does One Represent a Risk Factor for the Other?
- Serum Vitamin D Levels and Risk for Migraine
- Rimegepant Orally Dissolving Formulation Provides Rapid Relief From Acute Migraine
- Updated Evidence-Based Recommendations for Buprenorphine Treatment
- Prescription Digital Therapeutic Approved for Opioid Use Disorder
- Persistence of Post-Traumatic CRPS Associated With Initial Pain Sensitization
- Comparable Incidence, Intensity of Tourniquet Pain With Infraclavicular, Axillary Brachial Plexus Blocks
- Many Patients Withhold Information From Clinicians
- Shifting Pattern Seen for Primary Care Office Visits
- Questionnaire Reliably Predicts Effect of Migraine on Work-Related Duties
- Clinicians Must Do Their Part to Address Inaccurate Online Health Information