Generic Name and Formulations:
Isoniazid 300mg; scored tabs.
Various generic manufacturers
Indications for Isoniazid:
Prophylaxis and treatment of susceptible tuberculosis.
Prophylaxis: 300mg once daily. Active infection: 5mg/kg daily; max 300mg once daily. Do not interrupt therapy.
Prophylaxis: 10mg/kg once daily; max 300mg daily. Active infection: 10–20mg/kg once daily; max 500mg daily. Do not interrupt therapy.
Drug-induced hepatitis. Previous isoniazid-associated hepatic injury. Severe adverse reactions to isoniazid (eg, drug fever, chills, arthritis). Acute liver disease of any etiology.
Impaired renal or hepatic function. Monitor hepatic and ocular function. Alcoholism. Diabetes. Increased risk of liver damage with increasing age. Multiple drug therapy and concomitant pyridoxine may be necessary. Pregnancy. Nursing mothers.
Potentiates phenytoin. Alcohol increases risk of hepatitis. Pyridoxine deficiency increases risk of neuropathy.
Peripheral neuropathy (esp. in slow acetylators), elevated serum transaminases (SGOT; SGPT), bilirubinemia, bilirubinuria, jaundice, hepatitis (may be fatal), nausea, vomiting, epigastric distress, pancreatitis, blood dyscrasias, hypersensitivity reactions (eg, skin eruptions, TEN, DRESS), pyridoxine deficiency, hyperglycemia, pellagra, metabolic acidosis, gynecomastia, rheumatic syndrome, SLE-like syndrome.
Formerly known under the brand names INH, Laniazid.
Clinical Pain Advisor Articles
- Virtual Reality May Effectively Reduce Sensory, Affective, and Cognitive Pain During Labor
- Suprazygomatic Sphenopalatine Ganglion Block May Quickly Relieve Status Migrainosus Pain
- Reducing Mortality After Overdose: Is Treatment for Opioid Use Disorder Effective?
- A Physician's Guide to Incorporating Patient Spirituality in Practice
- Low Literacy Self-Management Program for Chronic Pain May Be Effective
- Neuropathic Pain Medications
- Higher Buprenorphine Dose May Not Increase Severity of Neonatal Abstinence Syndrome
- Terms Used for Addiction May Be Associated With Explicit, Implicit Bias
- Ketamine Infusions May Be Effective for Refractory Headache
- Physical, Psychosocial Activity May Be Protective Against Development of Chronic Pain in Older Adults
- FDA Approves Minimally-Invasive, Non-Drug Therapy for Pain Management
- Chronic Migraine and Medication Overuse Headache Linked to Stress
- Set of Personality Traits May Predict Prescription Drug Use, Misuse in Young Adults
- The Opioid Crisis: District by District
- Opioid Administration, Prescribing in the ED on the Decline in Recent Years