Buprenorphine maintenance treatment for opioid dependence may result in hyperalgesia and prevent morphine-associated antinociception.
Chronic pain experienced by patients with pachyonychia congenita may be caused by damage to the peripheral nerve fibers, with the hyperalgesia and allodynia observed in affected regions likely to be manifestations of peripheral sensitization.
The higher interictal levels of oxytocin observed in patients with chronic migraine compared with unaffected individuals may contribute to the affective component of experimental pain.
In patients with multiple sclerosis, lesions in the right dorsolateral prefrontal cortex and posterior periventricular area may be associated with hypo and hyperalgesia.
Intraoperative low-dose naloxone reduced postoperative hyperalgesia but had no effect on pain when combined with high-dose remifentanil for elective thyroid surgery.
The effects of central sensitization extend beyond nociceptive pathways to other sensory modalities.
This study sheds light on the role of social and environmental cues in pain pathogenesis and has implications for the treatment of chronic pain patients.
Involvement of microglia, inflammation
Clinical Pain Advisor Articles
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- Integrating Psychological Interventions Into Chronic Pain Management
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- Investigational Treatment Shows Promise in Chronic Low Back Pain
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- Incorporating Guidelines Into Clinical Practice: An Interview With Gary L. LeRoy, MD
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