Pharmacology

Latest

Does Extended Steroid Exposure Increase Adverse Event Incidence?

By

Steve Duffy

The authors noted that, ‘For most adverse events, all levels of corticosteroid use exhibited significant risks of increased incidence compared to intermittent use.’

Naltrexone May Mitigate Stimulant-Induced Euphoria Associated With ADHD Treatment

By

Gary Rothbard, MD

Euphoria associated with the stimulant methylphenidate may be mitigated by co-administration of naltrexone in patients with attention-deficit/hyperactivity disorder.

Gabapentinoids: Are They Overprescribed?

Clinicians may be overprescribing gabapentinoids, in part as a response to the opioid epidemic, and prescribing them for almost any type of pain.

Interchangeability Study Initiated for Adalimumab Biosimilar

By

Da Hee Han, PharmD

Boehringer Ingelheim has initiated a clinical study to investigate the interchangeability between an adalimumab biosimilar candidate and Humira.

Off-label Antidepressant Prescriptions Often Unsupported by Strong Evidence

By

Haymarket Media

These findings highlight an urgent need to produce more evidence on the risks and benefits of off-label antidepressant use.

The Dichotomy of Substance P in Mediating Analgesia in the PNS and Nociception in the CNS

By

Florence Chaverneff, Ph.D.

Peripheral anti-nociceptive effects of Substance P

Coprescribing Naloxone to Opioid Users Helps Reduce ER Visits

Finding supports naloxone prescriptions for patients taking opioids for chronic pain

Pharmacogenetic Testing: A Good Tool for Treating Patients with Pain

By

Colleen Hall

Pharmacogenetic testing yields information that informs how an individual will metabolize medications.

Prescription Medication Use on the Rise in the United States

Many adults take five or more medications, often for preventable ills.

Using PAMORA for Opioid-Induced Constipation

Naloxegol functions as a peripherally acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids.