According to the American Podiatric Medical Association, people in the United States log approximately 75,000 miles on their feet by age 50 years,1 making foot pain a common complaint heard in healthcare clinics across the nation.

“Abnormalities in gait, ill-fitting shoes, repetitive motion, and trauma can all result in foot pain,” said Andrew Rader, DPM, founder of Indiana Foot & Ankle in Newburgh. “One common cause is neuralgia in the intermetatarsal region of the forefoot, known as Morton’s neuroma.”

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Morton’s neuroma is the formation of a mass of nerve fibers and cells, the cause of which can be multifactorial, including trauma, malformation, infection, or an overgrowth of vasculature/axons, Rader explained. When found in the intermetatarsal spaces, the neuroma is actually a compression neuropathy of the common digital nerve.

“Women are up to 10 times more likely to be affected, and average age of onset is about 50 years,” Dr. Rader said.

Patients commonly described the pain as cramping, stabbing, burning, aching, gnawing, radiating, and/or throbbing and may describe the sensation as having a “rolled-up sock” feeling. It is often exacerbated by tight-fitting shoe gear and physical activity.

Clinical examination is often adequate for diagnosing the pathology. Physical findings on examination may include splaying of the toes, impaired sensation on adjacent aspects of the plantar digits, and a positive Mulder’s sign. Dr. Rader emphasized that magnetic resonance imaging and diagnostic ultrasound can be used for cases in which the diagnosis is ambiguous. Imaging modalities can also be used for cases in which multiple lesions or multiple web space involvement is suspected.

Treatment options

Once a diagnosis of Morton’s neuroma is made, treatment options are wide ranging but largely anecdotal, according to Dr. Radar.

Conservative treatment with accommodative shoe-gear changes improved symptoms in as many as 41% of patients in a 1995 study by Bennett and coworkers.2 A study by Saygi and colleagues in 2005 reported improvement in symptoms in 63% of individuals using footwear modification with orthoses alone.3  However, prescription padding and orthoses to control pronatory and supinatory motion forces are typically ineffectual for pain relief.

This article originally appeared on MPR