During the American Academy of Neurology’s 2017 Annual Meeting in Boston, April 22-28, researchers from the department of experimental biomedicine and clinical neuroscience at the University of Palermo, Italy, presented a study showing the effectiveness of transcranial random noise stimulation (tRNS) in alleviating fibromyalgia-associated symptoms.1
Previous research in patients with fibromyalgia indicates that transcranial direct current stimulation (tDCS) of the motor cortex alleviates pain, while tDCS of the dorsolateral prefrontal cortex leads to improvements in disease-related psychological factors (ie, anxiety and depression) and cognitive function.2-4
A non-invasive technique that allows to modulate cortical neuronal activity by applying a weak current to the scalp, tDCS, was shown to be effective, safe, and amenable to clinical practice. The precise mechanisms underlying the effectiveness of this technique are poorly understood, but it is postulated that tDCS may affect the excitability of neurons by changing their resting membrane potential.2 Lasting effects resulting from tDCS may result from its modulation of long-term depression and potentiation, as well as its impact on functional connectivity, both in the region directly stimulated and in distant, but structurally connected, regions, as with tDCS stimulation of the primary motor cortex, which also has an impact on the thalamus and dorsal prefrontal cortex.2 In addition, tDCS of the primary motor cortex was found to activate µ-opioid receptors in the periaqueductal gray matter, precuneus, and left prefrontal cortex, providing analgesia to thermal stimuli.5
In the current study, tRNS — the application of an alternating current to the cortex delivered at random frequencies — was used in women with fibromyalgia (n=20; age 26 to 67). Study participants were randomly assigned to 2 treatment groups: one receiving active (real) tRNS and one sham (placebo) tRNS daily for 2 weeks, excluding weekends. Prior to and following tRNS treatment, patients were asked to take a battery of tests: the visual analogue scale (VAS) to evaluate pain levels, and the Fibromyalgia Impact Evaluation Questionnaire. In addition, patients’ psychological state was assessed using the Mini Mental State Examination, the Hospital Anxiety and Depression Scale, as well as the Trail Making Test, the Rey Auditory Verbal Learning Test, the Forward and Backward Digit Span, and the FAS verbal fluency test to measure executive cognitive function.
Compared with women in the sham stimulation group, women who had received real tRNS reported improvements in fibromyalgia-related pain, overall disease impact, anxiety, depression, and executive function.
The researchers concluded that tRNS is superior to tDCS in the treatment of fibromyalgia, as it improves cognitive function in addition to pain. They added that pairing tRNS with stochastic resonance may lead to longer-lasting and more widespread benefits by synchronizing neural activity.
- La Bianca G, Curatolo M, Romano M, Fierro B, Brighina F. Motor cortex tRNS ameliorates pain, anxiety, depression, quality of life, and cognitive impairment in patients with fibromyalgia: preliminary results of a randomized sham-controlled trial. Presented at: the American Academy of Neurology 2017 Annual Meeting; April 22-28; Boston, Massachusetts.
- Cummiford CM, Nascimento TD, Foerster BR, et al. Changes in resting state functional connectivity after repetitive transcranial direct current stimulation applied to motor cortex in fibromyalgia patients. Arthritis Res Ther. 2016;18:40.
- Silva AF, Zortea M, Carvalho S, et al. Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex modulates attention and pain in fibromyalgia: randomized clinical trial. Sci Rep. 2017;7(1):135.
- Alonzo A, Chan G, Martin D, Mitchell PB, Loo C. Transcranial direct current stimulation (tDCS) for depression: analysis of response using a three-factor structure of the Montgomery-Åsberg depression rating scale. J Affect Disord. 2013;150(1):91-95.
- Dossantos MF, Martikainen IK, Nascimento TD, et al. Building up analgesia in humans via the endogenous μ-opioid system by combining placebo and active tDCS: a preliminary report. PLoS ONE. 2014;9(7):e102350.