Flexion Therapeutics announced the availability of Zilretta (triamcinolone acetonide extended-release injectable suspension) indicated for the management of pain associated with osteoarthritis (OA) of the knee. 

Zilretta, approved in October 2017, consists of an extended-release microsphere formulation for intra-articular injection. It combines a short-acting corticosteroid with a polylactic-co-glycolic acid (PLGA) matrix to provide pain relief over 12 weeks.

Triamcinolone acetonide binds to and activates the glucocorticoid receptor, leading to activation of anti-inflammatory transcription factors such as lipocortins and inhibition of inflammatory transduction pathways by blocking the release of arachidonic acid and preventing the synthesis of prostaglandins and leukotrienes.

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Zilretta is not intended for repeat administration. It is available as a single-dose kit containing a vial of microsphere powder (32mg triamcinolone acetonide), diluent, and a vial adapter.

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Flexion Therapeutics announces full commercial launch and nationwide availability of Zilretta (triamcinolone acetonide extended-release injectable suspension) [press release]. Burlington: Flexion; November 20, 2017. Accessed November 30, 2017.

This article originally appeared on MPR