The randomized, double-blind, controlled trial (N=24,081) included patients with rheumatoid arthritis or osteoarthritis who required chronic NSAID treatment.
In patients with painful hip osteoarthritis, an intramuscular glucocorticoid injection may effectively alleviate hip pain in the short-term.
The results of 2 randomized controlled trials showed that filgotinib improved quality of life when given in combination with methotrexate or as monotherapy in rheumatoid arthritis.
Laparoscopic gastric band surgery is associated with more improvement in knee osteoarthritis in younger patients and those without prior knee injury.
Intravenous and subcutaneous administration of tanezumab may provide similar analgesia and tolerability in patients with hip or knee osteoarthritis.
Improvement in pain at one month; decrease in global WOMAC score in eight patients after GAE
In clinical trials, treatment with Durolane resulted in greater reduction in Visual Analog Scale (VAS) pain scores at 3 and 6 months compared to Synvisc One (hylan G-F 20; Sanofi Genzyme).
Patients with knee osteoarthritis who can best benefit from treatment with intra-articular hyaluronic acid injections include patients with high levels of knee pain, younger individuals, persons with a high body mass index, and individuals with less severe structural damage.
The effects of glucosamine supplements in the treatment of patients with painful temporomandibular joint osteoarthritis were not superior to the effects of ibuprofen taken 2 to 3 times per day.
In patients with knee osteoarthritis, high pain levels and low pressure pain thresholds at baseline predicted worse pain outcomes after total knee replacement surgery, but did not predict outcomes after nonsurgical interventions.