General Pain

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General Pain

FDA Panel Votes on Posimir for Postsurgical Analgesia

January 24, 2020

The FDA’s Anesthetic and Analgesic Drug Products Advisory Committee (AADPAC) was split (6 to 6) on its decision as to whether Posimir (bupivacaine extended-release solution; Durect) should be approved for post-surgical analgesia.

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FDA Panels Vote “No” on the Abuse-Deterrent Opioid Aximris XR

Diana Ernst, RPh

The FDA’s Anesthetic and Analgesic Drug Products Advisory Committee and Drug Safety and Risk Management Advisory Committee voted against (2 “yes”, 24 “no”) the approval of Aximris XR

Validated Method Developed to Assess Pain Mechanisms in Chronic Pancreatitis

Clinical Pain Advisor Contributing Writer

Pain phenotypes can be used in the future to attempt prediction of response to treatment in patients with painful chronic pancreatitis and thus provides a framework for personalized pain management.

Ageism Predicts Significantly Worse Health Outcomes

Older persons who are less educated particularly likely to have adverse health effects of ageism

FDA Committees Vote on Novel Opioid for Chronic Low Back Pain

Diana Ernst, RPh

As a result of the vote, Nektar has decided to withdraw the New Drug Application for oxycodegol and to cease further development of the product.

Total Opioid Overdose Deaths Decreased With Medicaid Expansion

Medicaid expansion is associated with a reduction in total opioid overdose deaths and with increases in methadone-related mortality.

Effects of Opioid Agonists on Sleep Quality in Opioid Use Disorder

Rita Aghjayan

Patients perception of poor sleep differ from EEG-reported results.

Drop in Opioid Prescribing at ED Discharge Noted in Recent Years

The percentage of emergency department visits with an opioid prescribed increased from 2006-2007 to 2010-2011 then decreased to 2016-2017.

HIV-Associated Distal Peripheral Neuropathy in Resource-Limited Settings

Sweta Gupta

Although the prevalence of distal sensory peripheral neuropathy decreased following initiation of cART in people living with in resource-limiting settings, better strategies are needed.