In a randomized, placebo-controlled crossover study, researchers determined the effect of a 2-hour vasoactive intestinal polypeptide infusion on risk for migraine attacks.
Researchers investigated the longitudinal associations of serum inflammatory markers with joint symptoms and structures in patients with knee osteoarthritis.
Researchers analyzed the autopsies of patients who died from COVID-19 to understand the pathophysiology of COVID-19-related myopathy.
This study evaluated the use of lidocaine medicated plaster to treat postherpetic neuralgia.
The utility of bone marrow aspirate concentrate injections for knee osteoarthritis was evaluated.
Patients treated with gammaCore experienced clinically meaningful benefits.
The FDA has accepted the NDA for AXS-07 for the acute treatment of migraine.
The comparative efficacy of nonsteroidal anti-inflammatory drugs for lower back pain was examined.
Overall opioid overdoses and opioid-involved deaths continue to increase.
The primary efficacy endpoint was the change in the mean number of migraine days per month during the 12-week study period.
Anecdotal reports suggest that naltrexone, an opioid antagonist, may alleviate symptoms associated with CRPS.
The application is supported by data from the phase 3 SPIRIT program, which includes the SPIRIT 1 and SPIRIT 2 studies, as well as an open-label extension study.
This systematic analysis reviewed the comparative efficacy of mirogabalin vs pregabalin for diabetic peripheral neuropathic pain.
The recalled lot of Lidocaine HCl Topical Solution 4% (40mg/mL) was distributed at the wholesale and retail distribution levels.
The approval is supported by data from the phase 3 STOP 301 study, which evaluated the safety and tolerability of Trudhesa in 354 adults with migraine.
In a systematic literature review and meta-analysis, study authors evaluated the effects of systemic glucocorticoids on rheumatoid arthritis-related pain.
Routine annual vaccination is recommended for all patients 6 months of age and older who have no contraindications.
Patients treated with pentosan polysulfate should be monitored for key findings.
The researchers investigated the recovery model of hopelessness through interpersonal pathways of the COVID-19 epidemic.
Investigators evaluated the effectiveness of a 1-year moderate to vigorous exercise program, liraglutide treatment, or the combination of both, compared with placebo, for the maintenance of healthy weight loss.
The researchers’ goal was to determine whether occipital nerve stimulation could serve as an effective treatment for patients with medically intractable chronic cluster headache.
The study authors utilized the National Social Life, Health, and Aging Project leave-behind questionnaire to obtain data on a total of 6017 adults over 65 years of age.
A study found a high prevalence of pain in a cohort of veterans with COPD interested in physical activity and that physical activity could decrease pain in COPD.
Researchers assessed the role of ultrasonography in the evaluation of disease activity in patients with psoriatic arthritis with concomitant fibromyalgia syndrome.
The researchers performed a systematic review and meta-analyses to determine if epidural steroid injections result in clinically meaningful improvement in lumbosacral radicular syndrome.
Kloxxado is an opioid antagonist that delivers 8mg of naloxone hydrochloride per spray into the nasal cavity.
Investigators sought to evaluate the prevalence of antiplexin D1 antibodies in small fiber neuropathy, as well as their effects in vivo.
Investigators assessed the comparative prevalence of microbial contaminants found on the touchscreen and posterior surfaces of smartphones owned by healthcare workers.
The AHA has issued a Presidential Advisory Statement outlining considerations for addressing the effects of opioids on cardiovascular and neurovascular health.
This systematic review and meta-analysis of randomized controlled trials assessed the efficacy and safety of gabapentin and duloxetine for treating patients with painful diabetic peripheral neuropathy.
LYN-014 is an investigational oral, once-weekly, ultra-long-acting, extended-release levomethadone capsule to treat opioid use disorder.
The CDC also issued a health advisory about the urgent need to increase COVID-19 vaccination coverage.
Study authors conducted a meta-analysis of randomized controlled trials to study the effectiveness of psychotropic medications in children and adolescents with chronic pain.
In this study, the researchers explored the potential interaction between genetic risk and chronic obstructive pulmonary disease in relation to severe COVID-19.
The phase 3 RALLY study is evaluating the efficacy and safety of TNX-102 SL in 514 adult patients with fibromyalgia.
The researchers’ goal was to investigate the therapeutic effect of cranial microcurrent stimulation in patients with chronic tension-type headaches.
Researchers assessed the decline in high-risk GI and pancreato-biliary lesions detected during the COVID-19 pandemic due to reduced numbers of endoscopic procedures performed.
The researchers examined SARS-CoV-2 genomes isolated from individuals believed to have experienced vaccine breakthrough and compared them to the background of SARS-CoV-2 sequences from Washington State over the same time period.
Researchers proposed a nonsurgical approach with targeted colonic delivery of MCFAs, which induce EECs and neuronal activation leading to anorectic effects in adults with obesity.
Practitioners working in Tamil Nadu, India, once a COVID-19 hotspot, shared their experience with managing gastrointestinal services at the peak of the pandemic.
Data are lacking on the effectiveness of acupuncture in alleviating pain post total knee replacement.
Mask wearing is important as there are concerns about variants being more easily spread among young children, adolescents, and adults.
The researchers tested their hypothesis that a decrease in respiratory virus incidence would be associated with a reduction in inappropriate ambulatory antibiotic orders.
Researchers aimed to assess the efficacy and safety of oral imatinib in hospitalized patients with COVID-19 who required supplemental oxygen administration.
Researchers conducted a narrative review of the pharmacokinetics of major classes of migraine preventives and the implications of drug-drug interactions in treatment.
In a systematic review and meta-analysis, Neuroscience Research Australia investigators quantitatively analyzed 31 RCTs with a total of 6505 participants.
Researchers evaluated the association between Assessment of Spondyloarthritis International Society Health Index (ASAS-HI) and disease activity and burden in patients with spondyloarthritis.
A Weill Cornell Medicine team analyzed Health Care Cost Institute database claims, with opioid prescription gaps ≥30 days considered long-term nonuse.
Nevro’s SCS system for painful diabetic neuropathy will be available under the brand name HFX™ for PDN.
It is known that disparities exist among US adolescent suicide death rates by sex, race, and ethnicity. Study researchers look at suicidal ideation and attempts amidst these same parameters from 1991 and 2019.
The objective of this systematic review was to study the effects of lidocaine on postoperative pain scores and recovery after cardiac surgery.
The review authors sought to elucidate the neurological harms of methamphetamine, which are well-documented but poorly understood.
N-nitroso-varenicline may be associated with an increased cancer risk based on data from closely related nitrosamine compounds.
COVID-19 severity at hospital admission predicts complications even in young adults and those without pre-existing health conditions.
The researchers evaluated how an opioid restriction law in Florida affected the use of prescription NSAIDs.
One of the objectives of this study was to examine how early childhood factors at the individual-, parental-, and family-level predict pain trajectories.
Study researchers conducted a narrative review to update the public on the new classification of trigeminal neuralgia, clinical signs, pathophysiology, and management.
This review explores the cardiovascular consequences of opioids and the contributions of off-target electrophysiologic properties to mortality, and provides practical safety recommendations.
A joint opinion from the ACC, AHA, ESC, and WHF highlights the issue of burnout as one of most common negative barriers to clinician well-being that needs to be addressed for the provision of high-quality patient care.
Study authors analyzed data from 10,541 hospitalized patients with active COVID-19 disease to evaluate the relationship between the use of statins and COVID-19 outcomes.
The researchers’ goal was to provide the initial evidence for the safety and efficacy of sublingual ketamine in patients with chronic nonmalignant pain.
Researchers evaluated the effectiveness of the SARS-CoV-2 vaccination in the IBD population and the potential impact of immunosuppressive medications.
The researchers studied mothers of infants with neonatal abstinence syndrome and/or prenatal substance exposure and whether they received treatment for substance use disorder.
A narrative review summarized the findings of 69 prospective longitudinal studies to inform practitioners and policy makers about the outcomes of physical punishment and identified 7 key themes.
Researchers aimed to evaluate how bowel urgency and abdominal pain may improve with upadacitinib treatment, as indicted by health related quality of life outcomes.
Study researchers evaluated the potential of osmophobia in as a clinical diagnostic marker of migraine in children and adolescents.
Researchers conducted a nationwide cohort study to determine the association between autoimmune inflammatory rheumatic diseases and COVID-19 in South Korea, early in the pandemic.
Clinicians writing about the rising rates of suicide and suicidal behaviors among Black youth address the lack of suitable available data and call for the need to mobilize research for prevention.
Among other considerations, health care providers must avoid giving individual medical advice.
Researchers presented a study protocol for a trial evaluating the efficacy of 3 forms of virtual reality interventions for patients with highly prevalent chronic lower back pain.
Researchers compared clinical outcomes of single vs double antipseudomonal antibiotics used to treat pulmonary exacerbations in patients with cystic fibrosis.
Study reveals that almost 90% of men have hypogonadism at the time of hospital admission for COVID-19.
With depressive symptoms rising after an acute COVID-19 infection, study researchers looked at whether these symptoms are a consequence of stress associated with COVID or, do they reflect more specific sequelae associated with the pathophysiology of the illness.
While prior research indicates that cannabis use may increase the severity of certain psychiatric symptoms, its impact on suicidality is unknown. To inform this gap, investigators extracted data from the National Surveys on Drug Use and Health for the years 2008 through 2019.
Researchers studied the impact of current opioid agonist therapy on initiation of chronic hepatitis C virus treatment among a population of individuals who inject drugs.
Researchers sought to determine whether poorer health-related quality of life would be linked to responses about pain severity in patients with multiple myeloma.
A team of investigators conducted a Delphi study to provide evidence-based guidance to clinicians about management and care of patients with serious illnesses who misuse opioids or have opioid use disorder.
Researchers attempted to determine if medications for opioid use disorder integrated with infectious disease measures can lead to better infectious disease outcomes.
The aim of this study was to examine changes in postoperative opioid dispensing after vs before the CDC guideline release in March 2016.
Researchers analyzed data from patients with chronic non-cancer pain and opioid-induced constipation to determine PAC-SYM and PAC-QOL minimal clinically important difference values.
The researchers performed a systematic review of the current bronchoscopy guidelines on flexible bronchoscopy with a focus on evidence and recommendations for patient monitoring, capnometry, and observation time.
The aim of the study was to assess the benefits and risks associated with various acute treatments for episodic migraine.
The researchers’ goal was to evaluate the effectiveness of low-intensity focused ultrasound (LIFU) therapy in the management of cancer-related neuropathic pain (CNP).
SBRT was compared with external beam radiotherapy to determine which provided better pain control for patients with spinal metastases.
Investigators studied longer-term treatment with an integrated intervention with psychosocial counseling and supported referrals for antiretroviral therapy and substance use treatment.
Study data published in PLoS One suggest that gender minority (GM) adolescents may engage in substance use more frequently than their peers.
Researchers sought to determine whether smartphone-based virtual reality (VR) games are effective in reducing pain among pediatric patients in real-world burn clinics.
The researchers’ goal was to weigh the risks and benefits of acute treatments for episodic migraine in adults.
The Simplist ready-to-administer prefilled syringes require no assembly or point-of-care preparation.
The FDA is concerned that obtaining falsely low test results may lead to inappropriate follow-up assessments, which may result in patient harm.
Zynrelef is a dual-acting local anesthetic that delivers a fixed-dose combination of bupivacaine, an amide local anesthetic, and meloxicam, an NSAID.
The researchers’ goal was to determine if mandatory daily employee symptom attestation data could be used for syndromic surveillance to estimate COVID-19 hospitalizations in the communities where employees live.
A study found no significant increased risks for death or major adverse cardiac events among infected patients with established chronic kidney disease or end-stage kidney disease.
The AGA summarized their responses to the COVID-19 pandemic, with a focus on advocacy and legislative measures.
The researchers’ goal was to evaluate whether the 15-day threshold of headache days per month reflects significant differences in disability across the migraine and its spectrum.
A transitional care model utilizing NPs to conduct telehealth visits within 3 days of hospital discharge led to reduce health care costs and increased 14-day follow-up rates.
A team of investigators conducted a cross-sectional study determine whether neurologic symptoms were caused directly by SARS-CoV-2 infection.
Nerivio is a wireless remote electrical neuromodulation device approved for the acute treatment of episodic or chronic migraine in patients 12 years of age and older.
Researchers assessed longitudinal studies to determine the mediational role of mood as well as the directionality of effects between sleep, pain, and mood.
Researchers aimed to examine behavioral patterns with regard to vaccination against SARS-CoV-2 to identify pragmatic actions to increase vaccine coverage in this population.