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Off-Label Use of Antidepressants for Chronic Pain

In recent years, the off-label prescription of antidepressants for the treatment of chronic pain has increased, along with evidence of their effectiveness and mechanistic underpinnings when used for this purpose. Depression is a common comorbidity among patients with chronic pain, and the use of these agents may alleviate symptoms of both disorders. Typically, however, significantly…
vagus nerve stimulation

Reviewing Noninvasive Vagus Nerve Stimulation for Migraine, Cluster Headache

A substantial percentage of patients with primary headache disorders are unresponsive to standard pharmacologic therapies, with pain-free response rates of 45% at 15 minutes and 30% at 2 hours, following the use of rescue medications.1 Such findings, along with the range of side effects associated with these agents, highlight the need for novel treatment options…

Cannabinoids in the Treatment of RA: Current Status and Future Prospects

Researchers found data that showed in patients with rheumatoid arthritis, the delta-tetrahydrocannabinol found in medical cannabis is likely to contribute to an increase in heart rate in patients who are susceptible to atherosclerosis and cardiovascular disease. Medical cannabis was also not found to provide therapeutic effects when comparing it with a combination of cannabinoid type 1 antagonist, fatty acid amide hydrolase inhibitor, and nonpsychotropic cannabidiol.
young woman holding her head

The Complex Interplay Between Metacognition and Headache in Pediatric Patients

Researchers found data that in adults who had headaches as children, cognitive and psychomotor ability are compromised. In a Norwegian study, it was found that attention deficits were associated with migraine and nonclassifiable headache in patients aged 15 to 17 years. Metacognitive skills and anxiety, depression, motivation, academic performance, human social interactions, and stress symptoms are common headache triggers that researchers posit can be controlled and monitored by patients.

Cannabinoids in the Treatment of RA: Current Status and Future Prospects

Researchers found data that showed in patients with rheumatoid arthritis, the delta-tetrahydrocannabinol found in medical cannabis is likely to contribute to an increase in heart rate in patients who are susceptible to atherosclerosis and cardiovascular disease. Medical cannabis was also not found to provide therapeutic effects when comparing it with a combination of cannabinoid type 1 antagonist, fatty acid amide hydrolase inhibitor, and nonpsychotropic cannabidiol.
sliding doors in the front of an emergency department

Headache in the ED: Overview and Expert Interview

Researchers found data that showed, after consultation with an expert, optimal prevention of migraine headaches for patients who present in the emergency department includes both antiseizure medications, specifically, divalproex sodium, sodium valproate, or topiramate, and β-blockers, namely, metoprolol, propranolol, and timolol. In addition, triptans are suggested, as well as antidepressants, amitriptyline, and venlafaxine.
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